Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 12:27:38 GMT 2023
by
admin
on
Sat Dec 16 12:27:38 GMT 2023
|
| Protein Type | RECEPTOR |
| Protein Sub Type | CYTOKINE RECEPTOR |
| Sequence Origin | HUMAN |
| Sequence Type | COMPLETE |
| Record UNII |
B5GGG91KI4
|
| Record Status |
Validated (UNII)
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| Record Version |
|
-
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| Code System | Code | Type | Description | ||
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P61073
Created by
admin on Sat Dec 16 12:27:39 GMT 2023 , Edited by admin on Sat Dec 16 12:27:39 GMT 2023
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PRIMARY | |||
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P61073
Created by
admin on Sat Dec 16 12:27:39 GMT 2023 , Edited by admin on Sat Dec 16 12:27:39 GMT 2023
|
PRIMARY | |||
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B5GGG91KI4
Created by
admin on Sat Dec 16 12:27:39 GMT 2023 , Edited by admin on Sat Dec 16 12:27:39 GMT 2023
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PRIMARY | |||
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CXCR4
Created by
admin on Sat Dec 16 12:27:39 GMT 2023 , Edited by admin on Sat Dec 16 12:27:39 GMT 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_28 | 1_274 |
| 1_109 | 1_186 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_11 |
| N | 1_176 |
| O | 1_18 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
Binds to CXCR4, thereby preventing the binding of stromal cell-derived factor-1 (SDF-1 or CXCL12) to CXCR4 and inhibiting CXCR4 activation. This results in decreased proliferation and migration of CXCR4-expressing tumor cells. In addition, PF-06747143 promotes cell death through the induction of both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC).
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AGONIST -> TARGET |
Dimeric form acts as a partial agonist of CXCR4.
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INHIBITOR -> TARGET |
AGONIST
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
IC50
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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LIGAND->TARGET |
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INHIBITOR -> TARGET |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
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| Molecular Formula | CHEMICAL |
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