U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 18:25:04 GMT 2023
Edited
by admin
on Sat Dec 16 18:25:04 GMT 2023
Source Materials Class ORGANISM
Source Materials Type BACTERIUM
Source Materials State LIVE GENETICALLY MODIFIED
Organism Family Lactobacillaceae
Organism Genus Lactobacillus
Organism Species reuteri
Infraspecific Type STRAIN
Infraspecific Name R2LC
Part WHOLE
Record UNII
FBZ2DKU32N
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EMILIMOGENE SIGULACTIBAC
INN  
Official Name English
emilimogene sigulactibac [INN]
Common Name English
IPL100
Common Name English
RECOMBINANT LIVE LIMOSILACTOBACILLUS REUTERI BACTERIA (PREVIOUSLY KNOWN AS LACTOBACILLUS REUTERI), STRAIN R2LC, TRANSFORMED WITH A PLASMID EXPRESSING A CODON-OPTIMISED HUMAN C-X-C MOTIF CHEMOKINE LIGAND 12 ISOFORM ALPHA (CXCL12-1.ALPHA.; ALSO KNOWN AS ST
Common Name English
ILP-100
Code English
Code System Code Type Description
FDA UNII
FBZ2DKU32N
Created by admin on Sat Dec 16 18:25:04 GMT 2023 , Edited by admin on Sat Dec 16 18:25:04 GMT 2023
PRIMARY
INN
12097
Created by admin on Sat Dec 16 18:25:04 GMT 2023 , Edited by admin on Sat Dec 16 18:25:04 GMT 2023
PRIMARY
NCI_THESAURUS
C188572
Created by admin on Sat Dec 16 18:25:04 GMT 2023 , Edited by admin on Sat Dec 16 18:25:04 GMT 2023
PRIMARY
Related Record Type Details
EXPRESSED PROTEIN->VECTOR
TARGET -> AGONIST
Dimeric form acts as a partial agonist of CXCR4.
PARENT -> DERIVATIVE
PARENT ORGANISM -> INFRASPECIFIC
Related Record Type Details
ACTIVE MOIETY
immunomodulator

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN EMILIMOGENE SIGULACTIBAC EXPRESSED STROMAL CELL-DERIVED FACTOR 1 ALPHA PREPROTEIN JVL4Q62KAV
INSERTED GENE EXPRESSION VECTOR EMILIMOGENE SIGULACTIBAC TRANSGENE PLASMID BJH8KD4UJX
VECTOR EXPRESSED PROTEIN STROMAL CELL-DERIVED FACTOR 1-ALPHA CPN2JYW64D