Approval Year
| Substance Class |
Concept
|
| Record UNII |
7TS9C20ZWA
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Code | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C20401
Created by
admin on Sat Dec 16 15:13:48 GMT 2023 , Edited by admin on Sat Dec 16 15:13:48 GMT 2023
|
||
|
NCI_THESAURUS |
C129822
Created by
admin on Sat Dec 16 15:13:48 GMT 2023 , Edited by admin on Sat Dec 16 15:13:48 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
C131572
Created by
admin on Sat Dec 16 15:13:48 GMT 2023 , Edited by admin on Sat Dec 16 15:13:48 GMT 2023
|
PRIMARY | |||
|
7TS9C20ZWA
Created by
admin on Sat Dec 16 15:13:48 GMT 2023 , Edited by admin on Sat Dec 16 15:13:48 GMT 2023
|
PRIMARY |
This is a non-substance concept
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET -> INHIBITOR |
Binds to CXCR4, thereby preventing the binding of stromal cell-derived factor-1 (SDF-1 or CXCL12) to CXCR4 and inhibiting CXCR4 activation. This results in decreased proliferation and migration of CXCR4-expressing tumor cells. In addition, PF-06747143 promotes cell death through the induction of both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC).
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
This is a non-substance concept