U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 131 - 140 of 2893 results

Status:
Investigational
Source:
JAN:CHLORPYRIFOS-METHYL [JAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Chlorpyrifos-methyl is a broad-spectrum organophosphorous insecticide and potential toxic pollutant widely used in agriculture and effective against a wide range of insect pests in commercial importance crops. Chlorpyrifos-methyl have endocrine disruption activity, especially anti-androgenic effects and Chlorpyrifos-methyl administration leads to hepatotoxicity and neurotoxicity in mammals. The fish exposed to chlorpyrifos-methyl exhibited behavioral changes in the form of neurotoxin toxicity: less general activity than control group, loss of equilibrium, erratic swimming and staying motionless at a certain location
Status:
Investigational
Source:
NCT04700345: Not Applicable Interventional Active, not recruiting Subdural Hematoma, Non-acute
(2021)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Bifenthrin is a pyrethroid insecticide used in urban and agricultural applications. Bifenthrin is a broad-spectrum insecticide that modifies voltage-gated ion channels disrupting the normal function of nerve cells. In May 2010 EU Commission withdrawn plant protection products containing bifenthrin.
Status:
Investigational
Source:
INN:triclofenol piperazine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

2,4,5-Trichlorophenol is a grey flake or needle-shaped solid. It is used as an intermediate in the manufacture of the herbicide 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) and as a fungicide and bactericide. 2,4,5-trichlorophenol (triclofenol piperazine, Ranestol) is an antifungal agent, which was also used against light hookworm infections. Thirty persons who were positive for hookworm eggs in their stools were treated with 50 mg/kg of triclofenol piperazine dissolved in 5 per cent polyethylene glycol Ranestol® in soft gelatin capsules. Nineteen of these showed 77 to 100 % reduction in egg count average when compared with the pre-treatment counts. Side reactions were limited to mild and transient nausea in 23, vomiting in 7, transient abdominal cramps and headache in 2 each. 2,4,5-trichlorophenol complexed with dicyclohexylamine was used for treatment of experimental mycosis. From the mycological and clinical evaluation the conclusion can be drawn that the effect of phenol in lipophilic ointment is comparable to that of clotrimazole.
Status:
Investigational
Source:
NCT04182126: Not Applicable Interventional Recruiting LLIN, PBO LLIN, IRS, Larviciding
(2019)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:guanoctine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Guanoctine was studied as an antihypertensive agent.
Status:
Investigational
Source:
NCT03658096: Not Applicable Interventional Enrolling by invitation Distal Radioulnar Joint Sprain
(2017)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
Inhal Toxicol. 2015;27(14):810-21.: Not Applicable Human clinical trial Completed N/A
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:demiditraz [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Demiditraz is used in veterinary as acaricide/tick repellant.
Status:
Investigational
Source:
INN:bromociclen [INN]
Source URL:

Class (Stereo):
CHEMICAL (EPIMERIC)


Bromociclen (5-(Bromomethyl)-1,2,3,4,7,7-hexachlorobicyclo[2.2.1]hept-2-ene; 5-(Bromomethyl)-1,2,3,4,7,7-hexachloro-2-norbornene) is a halogenated bicyclic insecticide. Bromociclen is used for the control of stored-product insects as well as against ecto-parasites.
Status:
Investigational
Source:
INN:dichloroxylenol [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Dichloroxylenol is a bactericide, preservative and deodorant. It is often used in the preparation of antiseptic and deodorant lotions and bath preparations. Dichloroxylenol also showed slightly greater activity against S. aureus Oxoid 701/1 Lot 610254 than against Escherichia coli and Salmonella typhi, indicating a probable role for cell wall in the susceptibility of bacteria to dichloroxylenol. The efficacy of either povidone-iodine (Betadine) or dichloroxylenol (Septocid) intrauterine infusions on the treatment of endometritis and/or cervicitis in cows was examined. The recovery and conception rates obtained after Betadine treatment were better than those obtained after Septocid. Moreover, healthy cows and those inseminated before post-partum day 180, having no more than 4-7 previous services, responded well to either Betadine or Septocid treatment.