Stereochemistry | ACHIRAL |
Molecular Formula | C6H3Cl3O |
Molecular Weight | 197.446 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=C(Cl)C=C(Cl)C(Cl)=C1
InChI
InChIKey=LHJGJYXLEPZJPM-UHFFFAOYSA-N
InChI=1S/C6H3Cl3O/c7-3-1-5(9)6(10)2-4(3)8/h1-2,10H
Molecular Formula | C6H3Cl3O |
Molecular Weight | 197.446 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
2,4,5-Trichlorophenol is a grey flake or needle-shaped solid. It is used as an intermediate in the manufacture of the herbicide 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) and as a fungicide and bactericide. 2,4,5-trichlorophenol (triclofenol piperazine, Ranestol) is an antifungal agent, which was also used against light hookworm infections. Thirty persons who were positive for hookworm eggs in their stools were treated with 50 mg/kg of triclofenol piperazine dissolved in 5 per cent polyethylene glycol Ranestol® in soft gelatin capsules. Nineteen of these showed 77 to 100 % reduction in egg count average when compared with the pre-treatment counts. Side reactions were limited to mild and transient nausea in 23, vomiting in 7, transient abdominal cramps and headache in 2 each. 2,4,5-trichlorophenol complexed with dicyclohexylamine was used for treatment of experimental mycosis. From the mycological and clinical evaluation the conclusion can be drawn that the effect of phenol in lipophilic ointment is comparable to that of clotrimazole.
Approval Year
Sample Use Guides
Triclofenol piperazine was administered as a
salt consisting of 82 per cent 2,4,5-triclofenol
and 18 percent piperazine which was enclosed
in a soft gelatin capsule consisting of a 5 per cent solution of the drug in polyethylene glycol 400. The capsules contained 250 or 100
mg. (base) of the salt. It was administered
with Coca Cola which was followed by hard
candy. Each patient received a single dose of
50 mg./kg. of body weight.
Route of Administration:
Oral
2,4,5-trichlorophenol (2,4,5-TCP) at concentrations from 25-600 ppm increased the size and granularity of the lymphocytes. 2,4,5-TCP induced the strongest and 4,5-DCC induced the weakest changes in these parameters. Moreover, 2,4,5-TCP induced the greatest loss of lymphocyte viability, which was statistically significant at concentrations of 125 and 600 ppm.