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Details

Stereochemistry ACHIRAL
Molecular Formula C6H3Cl3O
Molecular Weight 197.446
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2,4,5-TRICHLOROPHENOL

SMILES

OC1=C(Cl)C=C(Cl)C(Cl)=C1

InChI

InChIKey=LHJGJYXLEPZJPM-UHFFFAOYSA-N
InChI=1S/C6H3Cl3O/c7-3-1-5(9)6(10)2-4(3)8/h1-2,10H

HIDE SMILES / InChI

Molecular Formula C6H3Cl3O
Molecular Weight 197.446
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

2,4,5-Trichlorophenol is a grey flake or needle-shaped solid. It is used as an intermediate in the manufacture of the herbicide 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T) and as a fungicide and bactericide. 2,4,5-trichlorophenol (triclofenol piperazine, Ranestol) is an antifungal agent, which was also used against light hookworm infections. Thirty persons who were positive for hookworm eggs in their stools were treated with 50 mg/kg of triclofenol piperazine dissolved in 5 per cent polyethylene glycol Ranestol® in soft gelatin capsules. Nineteen of these showed 77 to 100 % reduction in egg count average when compared with the pre-treatment counts. Side reactions were limited to mild and transient nausea in 23, vomiting in 7, transient abdominal cramps and headache in 2 each. 2,4,5-trichlorophenol complexed with dicyclohexylamine was used for treatment of experimental mycosis. From the mycological and clinical evaluation the conclusion can be drawn that the effect of phenol in lipophilic ointment is comparable to that of clotrimazole.

Approval Year

PubMed

Sample Use Guides

In Vivo Use Guide
Triclofenol piperazine was administered as a salt consisting of 82 per cent 2,4,5-triclofenol and 18 percent piperazine which was enclosed in a soft gelatin capsule consisting of a 5 per cent solution of the drug in polyethylene glycol 400. The capsules contained 250 or 100 mg. (base) of the salt. It was administered with Coca Cola which was followed by hard candy. Each patient received a single dose of 50 mg./kg. of body weight.
Route of Administration: Oral
In Vitro Use Guide
2,4,5-trichlorophenol (2,4,5-TCP) at concentrations from 25-600 ppm increased the size and granularity of the lymphocytes. 2,4,5-TCP induced the strongest and 4,5-DCC induced the weakest changes in these parameters. Moreover, 2,4,5-TCP induced the greatest loss of lymphocyte viability, which was statistically significant at concentrations of 125 and 600 ppm.
Substance Class Chemical
Record UNII
32526637PN
Record Status Validated (UNII)
Record Version