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Restrict the search for
icosapent ethyl
to a specific field?
Status:
Possibly Marketed Outside US
Source:
Anipamil by Onbio Inc.
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (MIXED)
Targets:
Conditions:
Naftidrofuryl (INN), also known as nafronyl or as the oxalate salt naftidrofuryl oxalate or nafronyl oxalate, is a vasodilator used in the management of peripheral and cerebral vascular disorders. The drug act as a selective antagonist of 5-HT2 receptors. Naftidrofuryl is marketed under a variety of trade names, including Artocoron, Azunaftil, Di-Actane, Dusodril, Enelbin, Frilix, Gevatran, Iridus, Iridux, Luctor, Nafti, Naftoling, Naftodril, Nafoxal, Praxilene, Sodipryl retard, and Vascuprax. Praxilene belongs to a group of medicines known as ‘metabolic activators’. These are used to treat different types of blood circulation problems. Praxilene allows the body to make better use of the oxygen in your blood. Praxilene is used to treat the following symptoms: cramp-like pains; cramps in legs at night; severe pain in r legs when people are resting (rest pain); pale or blue fingers or toes which get worse when it is cold; numbness, tingling or burning feelings in the fingers or toes (Raynaud’s syndrome or acrocyanosis); open sores on the legs or feet (trophic ulcers); poor circulation caused by diabetes (diabetic arteriopathy).
Status:
Possibly Marketed Outside US
Source:
Brizin by Beecham [UK]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Benapryzine is a dialkylaminoethanol ester of diphenylacetic acid. It is a muscarinic cholinoceptor antagonist with negligible peripheral effects. Benapryzine in addition to its anti-acetylcholine action antagonizes both maximal electroshock and metrazol-induced convulsions in mice. This feature is not generally shown by anti-acetylcholine agents but is seen with orphenadrine. Side effects of benapryzine were rare. They are: drowsiness, dry mouth, confusion, disorientation, hallucinations and postural syncope with measurable postural hypotension. Benapryzine has been used as an antiparkinsonian agent.
Status:
Possibly Marketed Outside US
Source:
Amidefrine mesylate
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Status:
Withdrawn
Source:
Alphacetylmethadol
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Alphacetylmethadol (INN), aka α-acetylmethadol (AAM), is a synthetic opioid analgesic. Its levorotary enantiomer, levacetylmethadol, is an FDA-approved treatment for opioid addiction. Alphacetylmethadol is very similar in structure to methadone, a widely-prescribed treatment for opioid addiction. In the United States, it is a Schedule I controlled substance under the Controlled Substances Act with an ACSCN of 9603 and a 2013 annual manufacturing quota of 2 grams. Studies in rats indicate that alphacetylmethadol also evokes the heroin-like discriminative stimulus effects.
Status:
Withdrawn
Source:
Genaconazole
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Sch 39304 is a new broad-spectrum orally active triazole antifungal agent that is active, orally and topically, against a broad range of fungal pathogens, including superficial Trichophyton mentagrophytes and vaginal Candida albicans infections. The mechanism of action of SCH-39304 appears similar to those of ketoconazole and fluconazole, involving inhibition of cell membrane ergosterol synthesis. SCH-39304 has two asymmetrical carbon atoms, and the formulation used in clinical trials has been a racemic mixture of two enantiomers, active SCH-42427 (RR (+)-) and inactive SCH-424264 (SS (–)-). Unfortunately, hepatocarcinomas associated with the use of SCH-39304 in animals have sharply restricted the development and use of this agent.
Status:
US Approved Rx
(2020)
Source:
ANDA210834
(2020)
Source URL:
First approved in 1997
Source:
NaturVet ArthriSoothe by The Garmon Corporation
Source URL:
Class:
MIXTURE
Status:
US Approved Rx
(2007)
Source:
ANDA065381
(2007)
Source URL:
First approved in 1991
Source:
CEFZIL by CORDEN PHARMA
Source URL:
Class:
MIXTURE
Targets:
Conditions:
Cefprozil is a 2nd generation cephalosporin that is FDA approved for the treatment of mild to moderate infections of upper respiratory tract, lower respiratory tract, and uncomplicated skin and skin-structure infections. Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Common adverse reactions include diarrhea, nausea, vomiting, dizziness, abdominal pain and vaginitis. Nephrotoxicity has been reported following concomitant administration of aminoglycoside antibiotics and cephalosporin antibiotics. Concomitant administration of probenecid doubled the AUC for cefprozil.
Status:
US Approved Rx
(1981)
Source:
ANDA087204
(1981)
Source URL:
First approved in 1949
Source:
EURAX by JOURNEY
Source URL:
Class:
MIXTURE
Conditions:
Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use. The drug was approved by FDA for the treatment of scabies and pruritic skin. Crotamiton is a mixture of the cis and trans isomers of N-ethyl-N-(o-methylphenyl)-2butenamide. Although the activity of crotamiton was shown both in vitro and in vivo, the mechanism of its action is still unknown.
Class:
MIXTURE
Broparestrol, (Z)- is an isomer of Broparestrol -- synthetic, nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that has been used in Europe as a dermatological agent and for the treatment of breast cancer. Broparestrol, (Z)- and Broparestrol, (E)- demonstrates antiestrogenic activity but, unlike broparestrol, were never marketed.
