U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C21H27NO3.ClH
Molecular Weight 377.905
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BENAPRYZINE HYDROCHLORIDE

SMILES

Cl.CCCN(CC)CCOC(=O)C(O)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=FHKKIWLAMPGDPZ-UHFFFAOYSA-N
InChI=1S/C21H27NO3.ClH/c1-3-15-22(4-2)16-17-25-20(23)21(24,18-11-7-5-8-12-18)19-13-9-6-10-14-19;/h5-14,24H,3-4,15-17H2,1-2H3;1H

HIDE SMILES / InChI
Benapryzine is a dialkylaminoethanol ester of diphenylacetic acid. It is a muscarinic cholinoceptor antagonist with negligible peripheral effects. Benapryzine in addition to its anti-acetylcholine action antagonizes both maximal electroshock and metrazol-induced convulsions in mice. This feature is not generally shown by anti-acetylcholine agents but is seen with orphenadrine. Side effects of benapryzine were rare. They are: drowsiness, dry mouth, confusion, disorientation, hallucinations and postural syncope with measurable postural hypotension. Benapryzine has been used as an antiparkinsonian agent.

Approval Year

Sample Use Guides

30-45 mg daily
Route of Administration: Oral
Name Type Language
BENAPRYZINE HYDROCHLORIDE
MI   USAN  
USAN  
Official Name English
BENAPRYZINE HCL
Common Name English
BENAPRYZINE HYDROCHLORIDE [USAN]
Common Name English
BENAPRYZINE HYDROCHLORIDE [MI]
Common Name English
BENZENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-PHENYL-, 2-(ETHYLPROPYLAMINO)ETHYL ESTER HYDROCHLORIDE
Common Name English
BENAPRIZINE HYDROCHLORIDE
Common Name English
BRL-1288
Code English
2-(Ethylpropylamino)ethyl benzilate hydrochloride
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29704
Created by admin on Fri Dec 15 15:01:24 GMT 2023 , Edited by admin on Fri Dec 15 15:01:24 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID90185850
Created by admin on Fri Dec 15 15:01:24 GMT 2023 , Edited by admin on Fri Dec 15 15:01:24 GMT 2023
PRIMARY
NCI_THESAURUS
C78060
Created by admin on Fri Dec 15 15:01:24 GMT 2023 , Edited by admin on Fri Dec 15 15:01:24 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110766
Created by admin on Fri Dec 15 15:01:24 GMT 2023 , Edited by admin on Fri Dec 15 15:01:24 GMT 2023
PRIMARY
CAS
3202-55-9
Created by admin on Fri Dec 15 15:01:24 GMT 2023 , Edited by admin on Fri Dec 15 15:01:24 GMT 2023
PRIMARY
FDA UNII
LNV63FWR8M
Created by admin on Fri Dec 15 15:01:24 GMT 2023 , Edited by admin on Fri Dec 15 15:01:24 GMT 2023
PRIMARY
SMS_ID
300000023715
Created by admin on Fri Dec 15 15:01:24 GMT 2023 , Edited by admin on Fri Dec 15 15:01:24 GMT 2023
PRIMARY
PUBCHEM
18550
Created by admin on Fri Dec 15 15:01:24 GMT 2023 , Edited by admin on Fri Dec 15 15:01:24 GMT 2023
PRIMARY
MERCK INDEX
m66
Created by admin on Fri Dec 15 15:01:24 GMT 2023 , Edited by admin on Fri Dec 15 15:01:24 GMT 2023
PRIMARY Merck Index