BENAPRYZINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H27NO3.ClH
Molecular Weight	377.905
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCCN(CC)CCOC(=O)C(O)(C1=CC=CC=C1)C2=CC=CC=C2

InChI

InChIKey=FHKKIWLAMPGDPZ-UHFFFAOYSA-N

InChI=1S/C21H27NO3.ClH/c1-3-15-22(4-2)16-17-25-20(23)21(24,18-11-7-5-8-12-18)19-13-9-6-10-14-19;/h5-14,24H,3-4,15-17H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C21H27NO3
Molecular Weight	341.444
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4616812 | https://www.ncbi.nlm.nih.gov/pubmed/4581246 | Morton, I.K., Hall, J.M. (2012) Concise Dictionary of Pharmacological Agents, page 46, retrieved from: https://books.google.ru/books?id=tsjrCAAAQBAJ

Benapryzine is a dialkylaminoethanol ester of diphenylacetic acid. It is a muscarinic cholinoceptor antagonist with negligible peripheral effects. Benapryzine in addition to its anti-acetylcholine action antagonizes both maximal electroshock and metrazol-induced convulsions in mice. This feature is not generally shown by anti-acetylcholine agents but is seen with orphenadrine. Side effects of benapryzine were rare. They are: drowsiness, dry mouth, confusion, disorientation, hallucinations and postural syncope with measurable postural hypotension. Benapryzine has been used as an antiparkinsonian agent.

Approval Year

Sample Use Guides

In Vivo Use Guide

30-45 mg daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:01:24 GMT 2023` Edited by `admin` on `Fri Dec 15 15:01:24 GMT 2023`
Record UNII	LNV63FWR8M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BENAPRYZINE HYDROCHLORIDE

Official Name

English

BENAPRYZINE HCL

Common Name

English

BENAPRYZINE HYDROCHLORIDE [USAN]

Common Name

English

BENAPRYZINE HYDROCHLORIDE [MI]

Common Name

English

BENZENEACETIC ACID, .ALPHA.-HYDROXY-.ALPHA.-PHENYL-, 2-(ETHYLPROPYLAMINO)ETHYL ESTER HYDROCHLORIDE

Common Name

English

BENAPRIZINE HYDROCHLORIDE

Common Name

English

BRL-1288

Code

English

2-(Ethylpropylamino)ethyl benzilate hydrochloride

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29704