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Description

Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use. The drug was approved by FDA for the treatment of scabies and pruritic skin. Crotamiton is a mixture of the cis and trans isomers of N-ethyl-N-(o-methylphenyl)-2butenamide. Although the activity of crotamiton was shown both in vitro and in vivo, the mechanism of its action is still unknown.

Originator

Approval Year

1949
70
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
EURAX

Approved Use

For eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin.

Launch Date

-6.4661763E11
Palliative
Approved
8429
EURAX

Approved Use

For eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin.

Launch Date

-6.491232E11
PubMed

PubMed

TitleDatePubMed
The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses.
1949 Jul
Treatment of scabies with crotamiton.
1988 May
Chromatography of crotamiton and its application to the determination of active ingredients in ointments.
1997 Jun
Patents

Patents

JP2000026299A
3
JP2001288085A
3
JP2001521945A
47
JP2002316904A
3
JP2003286162A
3
JP2005008599A
5
JP2006199693A
3
JP2008031079A
3
JP2008179564A
3
JP2008509189A
188
JP2011001338A
3
JP2011088862A
11
JPH03193728A
3
JPH05331064A
3
JPH06247847A
3
JPH0789853A
3
JPH08113537A
9
JPH0840898A
3
JPH0840899A
3
JPH11199485A
3
JPS60209515A
3
JPS62164624A
3
JPS63145226A
3
JPS63201119A
3
JPS63208518A
3
JPS63255227A
3

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Mixture
Created
by admin
on Sat Dec 16 08:27:47 UTC 2023
Edited
by admin
on Sat Dec 16 08:27:47 UTC 2023
Record UNII
D6S4O4XD0H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CROTAMITON
EP   INCI   INN   JAN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INN   INCI  
Official Name English
EURAX
Brand Name English
CROTAMITON [ORANGE BOOK]
Common Name English
CROTAMITON [USP MONOGRAPH]
Common Name English
crotamiton [INN]
Common Name English
CROTAMITON [EP MONOGRAPH]
Common Name English
CROTAMITON [JAN]
Common Name English
NSC-758951
Code English
2-BUTENAMIDE, N-ETHYL-N-(2-METHYLPHENYL)-
Common Name English
CROTAMITON [EP IMPURITY]
Common Name English
CROTAMITON [MART.]
Common Name English
CROTAMITON [USP IMPURITY]
Common Name English
N-ETHYLCROTONO-O-TOLUIDIDE
Common Name English
CROTAMITON [INCI]
Common Name English
N-Ethyl-O-crotonotoluidide
Common Name English
Crotamiton [WHO-DD]
Common Name English
CROTAN
Brand Name English
CROTAMITON [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QP53AX04
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
NCI_THESAURUS C28394
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
EPA PESTICIDE CODE 55701
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
Code System Code Type Description
MESH
C005553
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
INN
673
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
RS_ITEM_NUM
1151006
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
NSC
758951
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
MERCK INDEX
m3855
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY Merck Index
WIKIPEDIA
CROTAMITON
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
DRUG BANK
DB00265
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
DRUG CENTRAL
744
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
DAILYMED
D6S4O4XD0H
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
RXCUI
21766
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY RxNorm
EVMPD
SUB06828MIG
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
ECHA (EC/EINECS)
207-596-3
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
CAS
483-63-6
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
EPA CompTox
DTXSID6040664
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
ALANWOOD
crotamiton
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
ChEMBL
CHEMBL1200709
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
FDA UNII
D6S4O4XD0H
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
NCI_THESAURUS
C65353
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
CHEBI
31439
Created by admin on Sat Dec 16 08:27:47 UTC 2023 , Edited by admin on Sat Dec 16 08:27:47 UTC 2023
PRIMARY
All of the following components must be present:
Structure of CROTAMITON, (E)-
Structure of CROTAMITON, (Z)-
Related Record Type Details
Structure of N-Ethyl-N-(2-methylphenyl)formamide
IMPURITY -> PARENT
Structure of N-(2-Methylphenyl)-2-butenamide, (2E)-
IMPURITY -> PARENT
Structure of N-Ethyl-N-(3-methylphenyl)-2-butenamide, (2E)-
IMPURITY -> PARENT
Structure of N-ETHYL-N-(2-METHYLPHENYL)-3-BUTENAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
CROTAMITON
ACTIVE MOIETY
Definition References
NIH
NCATS
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