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Description

Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use. The drug was approved by FDA for the treatment of scabies and pruritic skin. Crotamiton is a mixture of the cis and trans isomers of N-ethyl-N-(o-methylphenyl)-2butenamide. Although the activity of crotamiton was shown both in vitro and in vivo, the mechanism of its action is still unknown.

Originator

Approval Year

1949
71
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8583
EURAX

Approved Use

For eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin.

Launch Date

1949
Palliative
Approved
8583
EURAX

Approved Use

For eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin.

Launch Date

1949
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
24.5 ng/mL
EXPERIMENT
https://www.tandfonline.com/doi/abs/10.3109/09546639209089058
500 mg single, topical
dose: 500 mg
route of administration: Topical
experiment type: SINGLE
co-administered:
CROTAMITON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
344 ng × h/mL
EXPERIMENT
https://www.tandfonline.com/doi/abs/10.3109/09546639209089058
500 mg single, topical
dose: 500 mg
route of administration: Topical
experiment type: SINGLE
co-administered:
CROTAMITON plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
10 % 2 times / day multiple, topical
Recommended
Dose: 10 %, 2 times / day
Route: topical
Route: multiple
Dose: 10 %, 2 times / day
Sources:
https://pubmed.ncbi.nlm.nih.gov/24898622/
unhealthy, CHILD|ADULT
Health Status: unhealthy
Age Group: CHILD|ADULT
Sex: M+F
Food Status: UNKNOWN
Sources:
https://pubmed.ncbi.nlm.nih.gov/24898622/
Sources:
https://pubmed.ncbi.nlm.nih.gov/24898622/
PubMed

PubMed

TitleDatePubMed
Topical ivermectin versus crotamiton cream 10% for the treatment of scabies.
2014-07
Treatment of scabies, permethrin 5% cream vs. crotamiton 10% cream.
2013
Chromatography of crotamiton and its application to the determination of active ingredients in ointments.
1997-06
Contact dermatitis from crotamiton.
1992-07
The sensitizing capacity of crotamiton.
1988-05
Treatment of scabies with crotamiton.
1988-05
Contact dermatitis due to crotamiton.
1986-10
Crotamiton lotion in pruritus.
1984-12
A single application of crotamiton lotion in the treatment of patients with pediculosis capitis.
1982-12
Crotamiton cream and lotion in the treatment of infants and young children with scabies.
1979
[Crotamiton and crotamiton hydrocortisone compounds in the treatment of pruritus].
1965-08-20
The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses.
1949-07
Patents

Patents

JP2000026299A
3
JP2001288085A
3
JP2001521945A
47
JP2002316904A
3
JP2003286162A
3
JP2005008599A
5
JP2006199693A
3
JP2008031079A
3
JP2008179564A
3
JP2008509189A
189
JP2011001338A
3
JP2011088862A
11
JPH03193728A
3
JPH05331064A
3
JPH06247847A
3
JPH0789853A
3
JPH08113537A
9
JPH0840898A
3
JPH0840899A
3
JPH11199485A
3
JPS60209515A
3
JPS62164624A
3
JPS63145226A
3
JPS63201119A
3
JPS63208518A
3
JPS63255227A
3

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
N-ETHYLCROTONO-O-TOLUIDIDE
Preferred Name English
CROTAMITON
EP   INCI   INN   JAN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INN   INCI  
Official Name English
EURAX
Brand Name English
CROTAMITON [ORANGE BOOK]
Common Name English
CROTAMITON [USP MONOGRAPH]
Common Name English
crotamiton [INN]
Common Name English
CROTAMITON [EP MONOGRAPH]
Common Name English
CROTAMITON [JAN]
Common Name English
NSC-758951
Code English
2-BUTENAMIDE, N-ETHYL-N-(2-METHYLPHENYL)-
Common Name English
CROTAMITON [EP IMPURITY]
Common Name English
CROTAMITON [MART.]
Common Name English
CROTAMITON [USP IMPURITY]
Common Name English
N-Ethyl-O-crotonotoluidide
Common Name English
Crotamiton [WHO-DD]
Common Name English
CROTAN
Brand Name English
CROTAMITON [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QP53AX04
Created by admin on Mon Mar 31 22:05:43 GMT 2025 , Edited by admin on Mon Mar 31 22:05:43 GMT 2025
NCI_THESAURUS C28394
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EPA PESTICIDE CODE 55701
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Code System Code Type Description
MESH
C005553
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PRIMARY
INN
673
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PRIMARY
RS_ITEM_NUM
1151006
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PRIMARY
NSC
758951
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PRIMARY
MERCK INDEX
m3855
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PRIMARY Merck Index
WIKIPEDIA
CROTAMITON
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PRIMARY
DRUG BANK
DB00265
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PRIMARY
DRUG CENTRAL
744
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PRIMARY
DAILYMED
D6S4O4XD0H
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PRIMARY
RXCUI
21766
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PRIMARY RxNorm
EVMPD
SUB06828MIG
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PRIMARY
ECHA (EC/EINECS)
207-596-3
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PRIMARY
CAS
483-63-6
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PRIMARY
EPA CompTox
DTXSID6040664
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PRIMARY
ALANWOOD
crotamiton
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PRIMARY
SMS_ID
100000083722
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PRIMARY
ChEMBL
CHEMBL1200709
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PRIMARY
FDA UNII
D6S4O4XD0H
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PRIMARY
NCI_THESAURUS
C65353
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PRIMARY
CHEBI
31439
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PRIMARY
All of the following components must be present:
Structure of CROTAMITON, (E)-
Structure of CROTAMITON, (Z)-
ACTIVE MOIETY
CROTAMITON
Definition References
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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