U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description

Crotamiton (N-ethyl-N-(2-methylphenyl) but-2-enamide) is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. Crotamiton is a mixture of the cis (Z) and trans (E) isomers. Crotamiton contains not less than 96.0 per cent and not more than the equivalent of 102.0 per cent of N-ethyl-N-(2-methylphenyl)but-2-enamide, calculated as the sum of the E- and Z-isomers, and not more than 15.0 per cent of the Z-isomer. Isomer-specific pharmacological activity of crotamiton is unknown.

Originator

Approval Year

1949
70
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8360
EURAX

Approved Use

For eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin.

Launch Date

-6.4661763E11
Palliative
Approved
8360
EURAX

Approved Use

For eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin.

Launch Date

-6.491232E11
PubMed

PubMed

TitleDatePubMed
The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses.
1949 Jul
[Crotamiton and crotamiton hydrocortisone compounds in the treatment of pruritus].
1965 Aug 20
Crotamiton cream and lotion in the treatment of infants and young children with scabies.
1979
A single application of crotamiton lotion in the treatment of patients with pediculosis capitis.
1982 Dec
Crotamiton lotion in pruritus.
1984 Dec
The sensitizing capacity of crotamiton.
1988 May
Contact dermatitis from crotamiton.
1992 Jul
Chromatography of crotamiton and its application to the determination of active ingredients in ointments.
1997 Jun
Treatment of scabies, permethrin 5% cream vs. crotamiton 10% cream.
2013
Topical ivermectin versus crotamiton cream 10% for the treatment of scabies.
2014 Jul
Patents

Patents

JP2000026299A
3
JP2001288085A
3
JP2001521945A
47
JP2002316904A
3
JP2003286162A
3
JP2005008599A
5
JP2006199693A
3
JP2008031079A
3
JP2008179564A
3
JP2008509189A
188
JP2011001338A
3
JP2011088862A
11
JPH03193728A
3
JPH05331064A
3
JPH06247847A
3
JPH0789853A
3
JPH08113537A
9
JPH0840898A
3
JPH0840899A
3
JPH11199485A
3
JPS60209515A
3
JPS62164624A
3
JPS63145226A
3
JPS63201119A
3
JPS63208518A
3
JPS63255227A
3

Sample Use Guides

In Vivo Use Guide
Massage cream or lotion (10%) into the skin.
Route of Administration: Topical
In Vitro Use Guide
The scabicidal action of crotamiton was demonstrated by its lethal action in concentrations of 5 and 10 per cent on Psoroptes cuniculi within 10 minutes after exposure, while a 2 per cent concentration killed this organism in 10 to 30 minutes.
Name Type Language
CROTAMITON
EP   INCI   INN   JAN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INN   INCI  
Official Name English
EURAX
Brand Name English
CROTAMITON [ORANGE BOOK]
Common Name English
CROTAMITON [USP MONOGRAPH]
Common Name English
crotamiton [INN]
Common Name English
CROTAMITON [EP MONOGRAPH]
Common Name English
CROTAMITON [JAN]
Common Name English
NSC-758951
Code English
2-BUTENAMIDE, N-ETHYL-N-(2-METHYLPHENYL)-
Common Name English
CROTAMITON [EP IMPURITY]
Common Name English
CROTAMITON [MART.]
Common Name English
CROTAMITON [USP IMPURITY]
Common Name English
N-ETHYLCROTONO-O-TOLUIDIDE
Common Name English
CROTAMITON [INCI]
Common Name English
N-Ethyl-O-crotonotoluidide
Common Name English
Crotamiton [WHO-DD]
Common Name English
CROTAN
Brand Name English
CROTAMITON [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QP53AX04
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
NCI_THESAURUS C28394
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
EPA PESTICIDE CODE 55701
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
Code System Code Type Description
MESH
C005553
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
INN
673
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
RS_ITEM_NUM
1151006
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
NSC
758951
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
MERCK INDEX
M3855
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY Merck Index
WIKIPEDIA
CROTAMITON
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
DRUG BANK
DB00265
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
DRUG CENTRAL
744
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
DAILYMED
D6S4O4XD0H
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
RXCUI
21766
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY RxNorm
EVMPD
SUB06828MIG
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
ECHA (EC/EINECS)
207-596-3
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
CAS
483-63-6
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
EPA CompTox
DTXSID6040664
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
ALANWOOD
crotamiton
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
ChEMBL
CHEMBL1200709
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
FDA UNII
D6S4O4XD0H
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
NCI_THESAURUS
C65353
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
CHEBI
31439
Created by admin on Thu Jul 06 13:53:27 UTC 2023 , Edited by admin on Thu Jul 06 13:53:27 UTC 2023
PRIMARY
All of the following components must be present:
Structure of CROTAMITON, (E)-
Structure of CROTAMITON, (Z)-
ACTIVE MOIETY
CROTAMITON
Definition References
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966