U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use. The drug was approved by FDA for the treatment of scabies and pruritic skin. Crotamiton is a mixture of the cis and trans isomers of N-ethyl-N-(o-methylphenyl)-2butenamide. Although the activity of crotamiton was shown both in vitro and in vivo, the mechanism of its action is still unknown.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
EURAX

Approved Use

For eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin.

Launch Date

1949
Palliative
EURAX

Approved Use

For eradication of scabies (Sarcoptes scabiei) and for symptomatic treatment of pruritic skin.

Launch Date

1949
PubMed

PubMed

TitleDatePubMed
The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses.
1949 Jul
[Crotamiton and crotamiton hydrocortisone compounds in the treatment of pruritus].
1965 Aug 20
Crotamiton cream and lotion in the treatment of infants and young children with scabies.
1979
A single application of crotamiton lotion in the treatment of patients with pediculosis capitis.
1982 Dec
Crotamiton lotion in pruritus.
1984 Dec
Contact dermatitis from crotamiton.
1992 Jul
Chromatography of crotamiton and its application to the determination of active ingredients in ointments.
1997 Jun
Topical ivermectin versus crotamiton cream 10% for the treatment of scabies.
2014 Jul
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
CROTAMITON
EP   INCI   INN   JAN   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD  
INN   INCI  
Official Name English
EURAX
Brand Name English
CROTAMITON [ORANGE BOOK]
Common Name English
CROTAMITON [USP MONOGRAPH]
Common Name English
crotamiton [INN]
Common Name English
CROTAMITON [EP MONOGRAPH]
Common Name English
CROTAMITON [JAN]
Common Name English
NSC-758951
Code English
2-BUTENAMIDE, N-ETHYL-N-(2-METHYLPHENYL)-
Common Name English
CROTAMITON [EP IMPURITY]
Common Name English
CROTAMITON [MART.]
Common Name English
CROTAMITON [USP IMPURITY]
Common Name English
N-ETHYLCROTONO-O-TOLUIDIDE
Common Name English
CROTAMITON [INCI]
Common Name English
N-Ethyl-O-crotonotoluidide
Common Name English
Crotamiton [WHO-DD]
Common Name English
CROTAN
Brand Name English
CROTAMITON [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QP53AX04
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NCI_THESAURUS C28394
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EPA PESTICIDE CODE 55701
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Code System Code Type Description
MESH
C005553
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PRIMARY
INN
673
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RS_ITEM_NUM
1151006
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NSC
758951
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MERCK INDEX
m3855
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PRIMARY Merck Index
WIKIPEDIA
CROTAMITON
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DRUG BANK
DB00265
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DRUG CENTRAL
744
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DAILYMED
D6S4O4XD0H
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PRIMARY
RXCUI
21766
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PRIMARY RxNorm
EVMPD
SUB06828MIG
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PRIMARY
ECHA (EC/EINECS)
207-596-3
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CAS
483-63-6
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EPA CompTox
DTXSID6040664
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ALANWOOD
crotamiton
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ChEMBL
CHEMBL1200709
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FDA UNII
D6S4O4XD0H
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PRIMARY
NCI_THESAURUS
C65353
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PRIMARY
CHEBI
31439
Created by admin on Sat Dec 16 08:27:47 GMT 2023 , Edited by admin on Sat Dec 16 08:27:47 GMT 2023
PRIMARY
All of the following components must be present:
Definition References