U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 12711 - 12720 of 12911 results

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)

Regrelor (INS50589) is a P2Y(12) ADP-receptor antagonist that regulates platelet function. Regrelor was found to be well-tolerated and have reversible effects. Its potential therapeutic utility in various cardiovascular settings has been studied. Initial results of canine models suggested that regrelor should be effective in protecting platelet function and reducing blood loss in human patients undergoing open-heart surgery. A phase II study testing regrelor for its safety and efficacy in reduction of postoperative bleeding and blood product transfusion was terminated due to adverse effects.
Status:
Possibly Marketed Outside US
Source:
Canada:O-PHENYLPHENOL
Source URL:
First approved in 2010
Source:
Fungus Fighter by Continental Manufacturing Chemist, Inc.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


AMMONIUM O-PHENYLPHENOLATE (also known as Ortho-phenylphenol, ammonium salt) is a toxic agent, which is used as a pesticide.
Status:
Possibly Marketed Outside US
Source:
Integra by U.S. Pharmaceutical Corporation
(2009)
Source URL:
First approved in 2009
Source:
Integra by U.S. Pharmaceutical Corporation
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Ensulizole (INN) (phenylbenzimidazole sulfonic acid) is a common sunscreen agent. In 1999, the United States Food and Drug Administration regulated that the name ensulizole be used on sunscreen labels in the United States. It is a selective UVB filter, allowing almost all UVA transmission. The scope of UVB is 290 to 340 nanometers whereas the UVA range is 320 to 400 nanometers. For better UVA protection, it must be paired with avobenzone, titanium dioxide, or zinc oxide; outside of the United States it can also be paired with a UV absorber of the Tinosorb or Mexoryl types. Because is water-soluble, it has the characteristic of feeling lighter on skin. As such, it is often used in sunscreen lotions or moisturizers whose aesthetic goal is a non-greasy finish. The free acid is poorly soluble in water, so it is only used as its soluble salts
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Ensulizole (INN) (phenylbenzimidazole sulfonic acid) is a common sunscreen agent. In 1999, the United States Food and Drug Administration regulated that the name ensulizole be used on sunscreen labels in the United States. It is a selective UVB filter, allowing almost all UVA transmission. The scope of UVB is 290 to 340 nanometers whereas the UVA range is 320 to 400 nanometers. For better UVA protection, it must be paired with avobenzone, titanium dioxide, or zinc oxide; outside of the United States it can also be paired with a UV absorber of the Tinosorb or Mexoryl types. Because is water-soluble, it has the characteristic of feeling lighter on skin. As such, it is often used in sunscreen lotions or moisturizers whose aesthetic goal is a non-greasy finish. The free acid is poorly soluble in water, so it is only used as its soluble salts
Flunixin meglumine is a potent, non-narcotic, non-steroidal, analgesic agent with anti-inflammatory and anti-pyretic activity was approved to use in horses, cattle and pigs. In horses it is recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders. It is also recommended for the alleviation of visceral pain associated with colic. In the cattle: it is indicated for the control of pyrexia associated with bovine respiratory disease, endotoxemia and acute bovine mastitis. It is also indicated for the control of inflammation in endotoxemia. Flunixin persists in inflammatory tissues and is associated with anti-inflammatory properties which extend well beyond the period associated with detectable plasma drug concentration. Flunixin meglumine is classified as a carboxylic acid. Its mechanism of action is believed to be primarily via the inhibition of cyclooxygenase (COX) enzymes. This inhibition results in decreased formation of cyclooxygenase-derived eicosanoids involved in the pathophysiology of inflammation, such as thromboxanes and prostaglandins.
Status:
Possibly Marketed Outside US
Source:
NCT00159848: Phase 4 Interventional Completed Impotence
(2003)
Source URL:

Class (Stereo):
CHEMICAL (UNKNOWN)


Lufenuron is used to fight fungal infections, since fungus cell walls are about one third chitin. Lufenuron is the active ingredient in the veterinary flea control medication Program. FDA approved this drug for use in dogs and cats. Available by prescription. Once the female flea ingests blood from a pet treated with lufenuron, 96% of egg development from fleas on cats and 99% of egg development from fleas on dogs is stopped. This helps prevent a continual flea problem. Lufenuron does not kill the adult flea and does not stop the flea from biting and causing flea allergy dermatitis. The drug is stored in the body fat and released into the bloodstream over the course of a month. Flea eggs laid prior to treating the pet may take several months to hatch; Program will not be effective until these fleas start to lay eggs. Therefore it may take several months to see the product's effectiveness. If quicker results are needed, use a product which will kill adult fleas; these will provide quicker relief for the pet. Cats require a higher dose per pound than dogs. After the cat injectable form is administered, 2-3 weeks are needed to reach therapeutic levels in the blood. The injectable form for cats is effective for 6 months.
Status:
Possibly Marketed Outside US
Source:
NCT00159848: Phase 4 Interventional Completed Impotence
(2003)
Source URL:

Class (Stereo):
CHEMICAL (UNKNOWN)


Lufenuron is used to fight fungal infections, since fungus cell walls are about one third chitin. Lufenuron is the active ingredient in the veterinary flea control medication Program. FDA approved this drug for use in dogs and cats. Available by prescription. Once the female flea ingests blood from a pet treated with lufenuron, 96% of egg development from fleas on cats and 99% of egg development from fleas on dogs is stopped. This helps prevent a continual flea problem. Lufenuron does not kill the adult flea and does not stop the flea from biting and causing flea allergy dermatitis. The drug is stored in the body fat and released into the bloodstream over the course of a month. Flea eggs laid prior to treating the pet may take several months to hatch; Program will not be effective until these fleas start to lay eggs. Therefore it may take several months to see the product's effectiveness. If quicker results are needed, use a product which will kill adult fleas; these will provide quicker relief for the pet. Cats require a higher dose per pound than dogs. After the cat injectable form is administered, 2-3 weeks are needed to reach therapeutic levels in the blood. The injectable form for cats is effective for 6 months.
Imidocarb is a carbanilide derivative with antiprotozoal activity. It is usually administered as the dipropionate salt. Imidocarb is a drug sold under the brand name Imizol and is used to treat canine ehrlichiosis. wo mechanisms of action have been proposed: As the effect of imidocarb on Trypanosoma brucei is antagonized by excess polyamines, it is has been suggested that imidocarb interferes with their production and/or use. Imidocarb blocks the entry of inositol into erythrocytes containing Babesia, resulting in starvation of the parasite. It is generally accepted in that imidocarb has anticholinesterase activity.

Showing 12711 - 12720 of 12911 results