U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C10H10O4
Molecular Weight 194.184
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of FERULIC ACID

SMILES

COC1=CC(\C=C\C(O)=O)=CC=C1O

InChI

InChIKey=KSEBMYQBYZTDHS-HWKANZROSA-N
InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+

HIDE SMILES / InChI

Approval Year

2009
359
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 9.78 µM [Ki]
Inhibitor
8297
 9.87 µM [Ki]
Inhibitor
8297
 7.41 µM [Ki]
Inhibitor
8297
 9.43 µM [Ki]
Inhibitor
8297
 7.04 µM [Ki]
Inhibitor
8297
 2.89 µM [Ki]
Inhibitor
8297
 2.4 µM [Ki]
Inhibitor
8297
 3.78 µM [IC50]
PubMed

PubMed

TitleDatePubMed
Isolation and quantitation of steroids from normal human amniotic fluid.
1968 Aug
Curcumin and curcumin derivatives inhibit Tat-mediated transactivation of type 1 human immunodeficiency virus long terminal repeat.
1998 Jan-Feb
Investigation of the potential of capillary electrophoresis with off-line matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for clinical analysis: examination of a glycoprotein factor associated with cancer cachexia.
1999 Feb 15
Bioactive constituents of the bark of Parkia biglobosa.
2000 Apr
Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.
2004 Jul 2
Antitubercular constituents of Valeriana laxiflora.
2004 Jun
Interactions of human serum albumin with chlorogenic acid and ferulic acid.
2004 Sep 24
Antioxidant and antigenotoxic effects of plant cell wall hydroxycinnamic acids in cultured HT-29 cells.
2005 Jun
Synergistic salubrious effect of ferulic acid and ascorbic acid on membrane-bound phosphatases and lysosomal hydrolases during experimental myocardial infarction in rats.
2006 Dec 23
Predicting the biological activities of 2-methoxyphenol antioxidants: effects of dimers.
2007 Mar-Apr
Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium.
2010 Dec 5
Ferulic acid protects against carbon tetrachloride-induced liver injury in mice.
2011 Apr 11
Interaction of cinnamic acid derivatives with commercial hypoglycemic drugs on 2-deoxyglucose uptake in 3T3-L1 adipocytes.
2011 Sep 28
Anti-inflammatory activity of hydroxycinnamic acid derivatives isolated from corn bran in lipopolysaccharide-stimulated Raw 264.7 macrophages.
2012 May
Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis C virus.
2013
Antifungal efficacy of some natural phenolic compounds against significant pathogenic and toxinogenic filamentous fungi.
2013 Oct
Anticonvulsant and behavioral effects observed in mice following treatment with an ester derivative of ferulic acid: Isopentyl ferulate.
2015 Dec 5
Investigation of the effects of some drugs and phenolic compounds on human dihydrofolate reductase activity.
2015 Mar
Patents

Patents

JP1013016A
2
JP2000041622A
2
JP2000125840A
2
JP2000129257A
2
JP2000229913A
2
JP2000247900A
4
JP2000273019A
3
JP2000308477A
4
JP2000325015A
2
JP2000325049A
2
JP2001161314A
2
JP2001253863A
2
JP2001354556A
2
JP2002003386A
2
JP2002030039A
2
JP2002053464A
4
JP2002080354A
4
JP2002080355A
4
JP2002080356A
4
JP2002080357A
4
JP2002080381A
4
JP2002145765A
4
JP2002145766A
2
JP2002145767A
2
JP2002154977A
4
JP2002180081A
7
JP2002255778A
10
JP2002291406A
4
JP2002291437A
2
JP2002363075A
2
JP2002371002A
2
JP2002533379A
53
JP2002541233A
400
JP2003033196A
7
JP2003038144A
2
JP2003040709A
2
JP2003055182A
2
JP2003081824A
4
JP2003128632A
2
JP2003128633A
2
JP2003212774A
2
JP2003261444A
4
JP2003292410A
2
JP2003515526A
462
JP2003516112A
4
JP2003531246A
4
JP2003531247A
7
JP2004026657A
2
JP2004049186A
2
JP2004065156A
2
JP2004137287A
4
Name Type Language
FERULIC ACID
HSDB   INCI   MI   USP-RS   WHO-DD  
INCI  
Official Name English
FERULIC ACID [INCI]
Common Name English
Ferulic acid [WHO-DD]
Common Name English
NSC-51986
Code English
4-HYDROXY-3-METHOXYCINNAMIC ACID
Systematic Name English
(E)-3-(4-HYDROXY-3-METHOXY-PHENYL)PROP-2-ENOIC ACID
Systematic Name English
(E)-FERULIC ACID
Common Name English
FERULIC ACID [USP-RS]
Common Name English
CONIFERIC ACID
Systematic Name English
Trans-Ferulic acid [WHO-DD]
Common Name English
FERULIC ACID (CONSTITUENT OF BLACK COHOSH) [DSC]
Common Name English
NSC-674320
Code English
TRANS-FERULIC ACID
Common Name English
FERULIC ACID [MI]
Common Name English
FERULIC ACID [HSDB]
Common Name English
NSC-2821
Code English
2-PROPENOIC ACID, 3-(4-HYDROXY-3-METHOXYPHENYL)-, (2E)-
Systematic Name English
Classification Tree Code System Code
DSLD 1643 (Number of products:16)
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
FDA ORPHAN DRUG 886422
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
Code System Code Type Description
PUBCHEM
445858
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
CAS
537-98-4
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
NSC
2821
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
SMS_ID
100000125953
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
RS_ITEM_NUM
1270311
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
FDA UNII
AVM951ZWST
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
NSC
674320
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
ECHA (EC/EINECS)
214-490-0
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
CAS
1135-24-6
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
NON-SPECIFIC STEREOCHEMISTRY
NSC
51986
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
DRUG BANK
DB07767
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
WIKIPEDIA
FERULIC ACID
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
CHEBI
17620
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
RXCUI
1368647
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY RxNorm
DAILYMED
AVM951ZWST
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
MESH
C004999
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
HSDB
7663
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
MERCK INDEX
m5359
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY Merck Index
EVMPD
SUB32804
Created by admin on Sat Dec 16 20:00:10 GMT 2023 , Edited by admin on Sat Dec 16 20:00:10 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of FERULIC ACID
SALT/SOLVATE (PARENT)
Structure of PIPERAZINE BISFERULATE
SALT/SOLVATE (PARENT)
Structure of SODIUM FERULATE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966