Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H20N6O.2C3H6O2 |
| Molecular Weight | 496.5588 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(O)=O.CCC(O)=O.O=C(NC1=CC=CC(=C1)C2=NCCN2)NC3=CC=CC(=C3)C4=NCCN4
InChI
InChIKey=AFGQXWSHYUHHNV-UHFFFAOYSA-N
InChI=1S/C19H20N6O.2C3H6O2/c26-19(24-15-5-1-3-13(11-15)17-20-7-8-21-17)25-16-6-2-4-14(12-16)18-22-9-10-23-18;2*1-2-3(4)5/h1-6,11-12H,7-10H2,(H,20,21)(H,22,23)(H2,24,25,26);2*2H2,1H3,(H,4,5)
Imidocarb is a carbanilide derivative with antiprotozoal activity. It is usually administered as the dipropionate salt. Imidocarb is a drug sold under the brand name Imizol and is used to treat canine ehrlichiosis. wo mechanisms of action have been proposed:
As the effect of imidocarb on Trypanosoma brucei is antagonized by excess polyamines, it is has been suggested that imidocarb interferes with their production and/or use. Imidocarb blocks the entry of inositol into erythrocytes containing Babesia, resulting in starvation of the parasite. It is generally accepted in that imidocarb has anticholinesterase activity.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL4768 |
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Target ID: CHEMBL2966 |
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Target ID: CHEMBL220 |
590.0 nM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | Imizol Approved UseFor the treatment of babesiosis in dogs with clinical signs and/or demonstrated Babesia organisms in the blood. Launch Date1997 |
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| Curative | IMIDOCARB Approved UseFor treatment of babesiosis in cattle and horses Launch Date2001 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia. | 1988 Jun |
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| Treatment of experimental pneumocystosis: review of 7 years of experience and development of a new system for classifying antimicrobial drugs. | 1992 Sep |
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| Determination of whole blood cholinesterase in different animal species using specific substrates. | 2001 Jun |
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| Depletion and bioavailability of imidocarb residues in sheep and goat tissues. | 2002 Apr |
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| Electron microscopic investigations on stages of dog piroplasms cultured in vitro: Asian isolates of Babesia gibsoni and strains of B. canis from France and Hungary. | 2002 Jan |
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| Residual effect of antibabesial drugs on the live redwater blood vaccines. | 2002 Oct |
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| Pharmacokinetics of imidocarb dipropionate in horses after intramuscular administration. | 2002 Sep |
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| Effects of imidocarb dipropionate in cats with chronic haemobartonellosis. | 2002 Summer |
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| Evaluation of certain veterinary drug residues in food. | 2003 |
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| Naturally acquired babesiosis in a reindeer (Rangifer tarandus tarandus) herd in Great Britain. | 2003 Feb |
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| Humoral immunity and reinfection resistance in dogs experimentally inoculated with Babesia canis and either treated or untreated with imidocarb dipropionate. | 2003 Jun 25 |
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| In-vivo therapeutic efficacy trial with artemisinin derivative, buparvaquone and imidocarb dipropionate against Babesia equi infection in donkeys. | 2003 Nov |
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| Concurrent bartonellosis and babesiosis in a dog with persistent thrombocytopenia. | 2003 Nov 1 |
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| Imidocarb, a potent anti-protozoan drug, up-regulates interleukin-10 production by murine macrophages. | 2003 Sep 19 |
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| [Autochthonous babesiosis in dogs in the Netherlands?]. | 2004 May 1 |
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| First isolation and molecular characterization of Ehrlichia canis in Spain. | 2004 Nov 10 |
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| Detection and molecular characterization of a novel large Babesia species in a dog. | 2004 Oct 5 |
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| [A literature review of equine piroplasmosis after an episode of acute babesiosis in a Dutch Standardbred foal after a stay in Normandy]. | 2005 Dec 1 |
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| Autochthonous canine babesiosis in The Netherlands. | 2005 Jul 15 |
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| Identification of anti-babesial activity for four ethnoveterinary plants in vitro. | 2005 Jun 10 |
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| Clinical and clinicopathological changes in 6 healthy ponies following intramuscular administration of multiple doses of imidocarb dipropionate. | 2005 Mar |
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| Effective imidocarb dipropionate therapy for Babesia shortti in falcons. | 2006 Feb 18 |
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| Pharmacokinetics and mammary elimination of imidocarb in sheep and goats. | 2006 Jul |
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| Failure of imidocarb dipropionate to clear experimentally induced Ehrlichia canis infection in dogs. | 2006 Jul-Aug |
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| Flow cytometric evaluation of selected antimicrobial efficacy for clearance of Anaplasma marginale in short-term erythrocyte cultures. | 2006 Jun |
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| Effect of imidocarb and levamisole on the experimental infection of BALB/c mice by Leishmania (Leishmania) amazonensis. | 2006 Jun 30 |
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| Clinicopathological changes and effect of imidocarb therapy in dogs experimentally infected with Babesia canis. | 2006 Mar |
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| Canine babesiosis in France. | 2006 May 31 |
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| Chemotherapy against babesiosis. | 2006 May 31 |
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| Clinical manifestations of canine babesiosis in Hungary (63 cases). | 2006 Sep |
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| Comparison of the efficacy of enrofloxacin, imidocarb, and oxytetracycline for clearance of persistent Anaplasma marginale infections in cattle. | 2006 Winter |
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| Pharmacokinetics and bioavailability of imidocarb dipropionate in swine. | 2007 Aug |
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| Molecular characterisation of Babesia gibsoni infection from a pit-bull terrier pup recently imported into South Africa. | 2007 Mar |
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| Therapeutic and prophylactic efficacy of imidocarb dipropionate on experimental Babesia ovis infection of lambs. | 2007 Oct 21 |
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| [Dogs babesiosis--still actually problem]. | 2008 |
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| Canine vector-borne diseases in Brazil. | 2008 Aug 8 |
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| Treatment of Mycoplasma wenyonii infection in cows with imidocarb dipropionate injection-acupuncture. | 2008 Dec |
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| Detection of persistent Cytauxzoon felis infection by polymerase chain reaction in three asymptomatic domestic cats. | 2008 Jul |
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| Putative clinical piroplasmosis in a Burchell's zebra (Equus quagga burchelli). | 2009 Dec |
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| Diagnosis and treatment of Babesia odocoilei in captive reindeer (Rangifer tarandus tarandus) and recognition of three novel host species. | 2009 Mar |
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| Residue depletion of imidocarb in Swine tissue. | 2009 Mar 25 |
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| Canine babesiosis: from molecular taxonomy to control. | 2009 Mar 26 |
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| Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission. | 2009 Mar-Apr |
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| Failure of imidocarb dipropionate to eliminate Hepatozoon canis in naturally infected dogs based on parasitological and molecular evaluation methods. | 2010 Aug 4 |
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| First case of babesiosis caused by Babesia canis canis in a dog from Norway. | 2010 Aug 4 |
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| Detection of Babesia divergens in southern Norway by using an immunofluorescence antibody test in cow sera. | 2010 Oct 6 |
Sample Use Guides
Use intramuscularly or subcutaneously at a rate of 6.6 mg/kg (3 mg/lb) body weight. Repeat the dose in two (2) weeks, for a total of two (2) treatments.
Route of Administration:
Other
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CFR |
21 CFR 522.1156
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CFR |
21 CFR 522.1155
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DTXSID4046604
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Imidocarb dipropionate
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1740238
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ZSM1M03SHC
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9983292
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259-791-8
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C76007
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55750-06-6
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300000023751
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ZSM1M03SHC
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C031719
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DBSALT001684
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ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
