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Restrict the search for
histamine
to a specific field?
Status:
Investigational
Source:
NCT04711915: Phase 1 Interventional Active, not recruiting Major Depressive Disorder
(2021)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Class (Stereo):
CHEMICAL (ACHIRAL)
Nemazoline (A-57219) is a nasal decongestant. It has alpha 1-agonist/alpha 2-antagonist activity and was more effective and long-acting than oxymetazoline on canine nasal mucosa, in-vitro and in-vivo. Upon intranasal administration to dogs, the compound was devoid of systemic effects up to a concentration 1000 times that needed for local decongestant effect (1.65 micrograms, atomized from a 1 microgram mL-1 solution) suggesting limited mucosal absorption. After nasal administration to rats for 15 days at a concentration 1000 times greater than that required for nasal decongestion, no mucosal tissue toxicity or systemic effects were seen.
Class (Stereo):
CHEMICAL (ACHIRAL)
Fuprazole was developed as a bronchodilator that has never been marketed. Information about the current use of this compound is not available.
Class (Stereo):
CHEMICAL (ACHIRAL)
Tagorizine (also known as AL-3264) is a pyridylacrylamidoalkylpiperazine derivative patented by Dainippon Pharmaceutical Co., Ltd as an antiallergic agent. Tagorizine acts as 5-lipoxygenase inhibitor and blocks histamine H1-receptors in isolated guinea pig trachea, inhibits antigen-induced histamine release from isolated rat peritoneal mast cells, and suppress leukotriene production from activated human leukocytes. In preclinical models Tagorizine inhibited the antigen-induced leukotriene production in the abdominal cavity of passively sensitized rats and suppressed the arachidonic acid-induced ear edema in mice.
Status:
Investigational
Class (Stereo):
CHEMICAL (RACEMIC)
Dimelazine is a sedative, antihistaminic agent.
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Decloxizine (UCB-1402; NSC289116) is a histamine 1 receptor antagonist. Decloxizine is a broncholyticum.
Class (Stereo):
CHEMICAL (ACHIRAL)
Eflumast (RP42068; N-(2-hydroxy-3-acetyl-5-fluorophenyl)-5-carboxamido-1H tetrazole) is an antiallergic agent. It was under development as an orally active antiasthmatic.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Diethazine is the antimuscarinic agent. It has actions similar to those of ethopropazine but it is more toxic. Diethazine is used for the palliative treatment of the parkinsonian syndrome. It is more useful in the treatment of Parkinson’s disease than in allergies. Blockade of single contractions observed in these experiments after administration of diethazine was independent of the frequency of stimulation of the nerve. This suggests that the drug acts directly on the postsynaptic receptor in the endplate.
Status:
Investigational
Source:
NCT01320553: Phase 2 Interventional Completed Allergic Conjunctivitis
(2011)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Zaltidine (CP-57,361) is a guanidinothiazolylimidazole compound
which is a highly specific H2-receptor antagonist. It potently inhibits gastric acid secretion. Zaltidine appears to be an effective treatment of duodenal ulcer in human studies. However, the incidence of hepatic damage (8%) seems higher than with commonly used H2-receptor antagonists.
