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Details

Stereochemistry ACHIRAL
Molecular Formula C30H36N4O
Molecular Weight 468.633
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of TAGORIZINE

SMILES

CC1=CC=C(\C=C\C(=O)NCCCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C=N1

InChI

InChIKey=DVYCNKDRINREMB-WUKNDPDISA-N
InChI=1S/C30H36N4O/c1-25-14-15-26(24-32-25)16-17-29(35)31-18-8-9-19-33-20-22-34(23-21-33)30(27-10-4-2-5-11-27)28-12-6-3-7-13-28/h2-7,10-17,24,30H,8-9,18-23H2,1H3,(H,31,35)/b17-16+

HIDE SMILES / InChI
Tagorizine (also known as AL-3264) is a pyridylacrylamidoalkylpiperazine derivative patented by Dainippon Pharmaceutical Co., Ltd as an antiallergic agent. Tagorizine acts as 5-lipoxygenase inhibitor and blocks histamine H1-receptors in isolated guinea pig trachea, inhibits antigen-induced histamine release from isolated rat peritoneal mast cells, and suppress leukotriene production from activated human leukocytes. In preclinical models Tagorizine inhibited the antigen-induced leukotriene production in the abdominal cavity of passively sensitized rats and suppressed the arachidonic acid-induced ear edema in mice.

Approval Year

PubMed

PubMed

TitleDatePubMed
Inhibition of leukotriene production by N-[4-[4-(diphenylmethyl)-1- piperazinyl]butyl]-3-(6-methyl-3-pyridyl) acrylamide (AL-3264), a new antiallergic agent.
1994 May
Patents

Patents

Sample Use Guides

rat 30 100 mg/kg
Route of Administration: Oral
Name Type Language
TAGORIZINE
INN  
INN  
Official Name English
BROIZINE [JAN]
Common Name English
AL-3264
Code English
tagorizine [INN]
Common Name English
AL3264
Code English
Classification Tree Code System Code
NCI_THESAURUS C1322
Created by admin on Fri Dec 15 16:35:19 GMT 2023 , Edited by admin on Fri Dec 15 16:35:19 GMT 2023
Code System Code Type Description
EVMPD
SUB10799MIG
Created by admin on Fri Dec 15 16:35:19 GMT 2023 , Edited by admin on Fri Dec 15 16:35:19 GMT 2023
PRIMARY
ChEMBL
CHEMBL154139
Created by admin on Fri Dec 15 16:35:19 GMT 2023 , Edited by admin on Fri Dec 15 16:35:19 GMT 2023
PRIMARY
FDA UNII
668QM8QJFS
Created by admin on Fri Dec 15 16:35:19 GMT 2023 , Edited by admin on Fri Dec 15 16:35:19 GMT 2023
PRIMARY
INN
7332
Created by admin on Fri Dec 15 16:35:19 GMT 2023 , Edited by admin on Fri Dec 15 16:35:19 GMT 2023
PRIMARY
CAS
118420-47-6
Created by admin on Fri Dec 15 16:35:19 GMT 2023 , Edited by admin on Fri Dec 15 16:35:19 GMT 2023
PRIMARY
SMS_ID
100000082995
Created by admin on Fri Dec 15 16:35:19 GMT 2023 , Edited by admin on Fri Dec 15 16:35:19 GMT 2023
PRIMARY
NCI_THESAURUS
C73066
Created by admin on Fri Dec 15 16:35:19 GMT 2023 , Edited by admin on Fri Dec 15 16:35:19 GMT 2023
PRIMARY
PUBCHEM
6436051
Created by admin on Fri Dec 15 16:35:19 GMT 2023 , Edited by admin on Fri Dec 15 16:35:19 GMT 2023
PRIMARY