Nitromersol (aka metaphen) is a mercury-containing organic compound that is primarily used as a disinfectant and for superficial skin infections. Nitromersol is a confirmed animal carcinogen. It can emit toxic fumes of NOx and mercury when destroyed by heat. In 1998 use of nitromersol (and other mercury-containing products) as OTC first-aid antiseptics and products for diaper rash and vaginal contraceptives was disallowed by the FDA. Nitromersol can cause hypersensitivity reactions, but it is still in use as a preservative for vaccines and antitoxins. Nitromersol does not irritate the skin or mucous membranes and has no impact on rubber or metallic instruments including surgical and dental tools. The signs and symptoms that are produced after an acute overdose of Nitromersol include hypersensitivity reactions, tremors, hypertension, rashes, salivation, photophobia, dysuria, photophobia, and gingivitis. The symptomatic adverse reactions produced by Nitromersol are more or less tolerable, but if they become severe they can include necrosis, bloody diarrhea, nausea, and vomiting, and be treated symptomatically.

Sulfarsphenamine is a methanesulfonic acid derivative that has been used in 1920s in the treatment of syphilis.

Picric acid is used as a high explosive, an oxidant in rocket fuels, in matches and leather processing, as a laboratory reagent for serum creatinine analysis in humans and experimental animals. There is not much information related to pharmacological and biological application of picric acid. But is known, that during the 1920s-30s, it was used either alone or in combination with butyl aminobenzoate as an antiseptic dressing for burn wounds. About 4% of patients treated with picric acid developed sensitization local dermatitis and at least one case of serious central nervous system dysfunction occurred following topical picric acid application. Picric acid does not sensitize directly, but only after conversion to a more reactive compound. Picric acid was positive in the Ames salmonella assay for mutagenicity when metabolic activation was present. It has also been reported to be non-mutagenic in the Ames test. Those contradictory results did not allow to draw a conclusion on picric acid mutagenicity. A review by a committee of the Health Council of the Netherlands in 2002, did not find published data on long-term toxicity, carcinogenicity, or reproductive toxicity.

AMMONIUM BORATE is used in fireproofing wood and textiles, and also in electrolytic condensers. It can be indirect additive used in food contact substances.

Thymol, a monoterpene, obtained from thyme oil or other volatile oils, is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions to help reduce and prevent plaque and gingivitis. Recently was shown, that this substance was able to significantly reduce the oxidative stress associated with cataract. The results suggested that thymol might be a potential therapeutic approach in the prevention of diabetic complications through its aldose reductase enzyme inhibitory and antioxidant activities.

Thymol iodide a dry powder antiseptic; has been used as a substitute for iodoform in skin diseases, wounds, ulcers, etc. It was shown that intrapleural instillation of a slurry of iodized talc (part of which is a thymol iodide) is a safe, adequate, and effective treatment for control of neoplastic or benign pleural effusions.

Iodoform is an organic compound with the formula CHI3. It was formerly used as an antiseptic wound powder. Iodoform is commonly used as radiopacifier for primary tooth root canal fllling, but its use in endodontics is controversial because of its potential for causing toxic effects. It is also used in veterinary medicine as an active ingredient in the ear powders for dogs and cats.

Proflavine is an acriflavine derivative used as a topical disinfectant agains gram-positive bacteria. Proflavine is toxic and carcinogenic in mammals and so it is used only as a surface disinfectant or for treating superficial wounds. Proflavine acts by interchelating DNA (intercalation), thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. This prevents bacterial reproduction. Proflavine was investigated for photodynamic theraphy of herpes but was discontinued due to several presentations of post-treatment Bowen's disease and higher lesion recrudescence periods. Proflavine is also investigated as a topical contrast agent for imaging and diagnosis of esophageal, oral, colon, cervical, uterine cancer and polyps.

Guaiacol is a naturally occurring organic compound first isolated by Otto Unverdorben in 1826. Although it is biosynthesized by a variety of organisms, this yellowish aromatic oil is usually derived from guaiacum or wood creosote. Guaiacol is used as a reducing co-substrate for COX reactions. It is mainly used as expectorant, antiseptic. It is used as cough suppressant, it is an ingredient of Pulmo Bailly (UK). Pulmo Bailly Cough Expectorant is indicated for relief for cough symptoms that are associated with a flu, cold, or other infection. It contains active ingredients, Codeine and Guajacol, which reduce discomfort and the urge to cough. Each 5 ml tablespoon of Pulmo Bailly contains 75 mg guaiacol and 7 mg codeine.

Antimicrobial agent Fluorosalan is classified as Category II for use as antiseptic handwash, healthcare personnel handwash, patient preoperative skin preoperative skin preparation, and surgical hand scrub products. In the 1994 TFM (59 FR 31402 at 31435-31436), FDA proposed that the active ingredient fluorosalan be found not GRAS/GRAE for the uses referred to in the 1994 TFM as antiseptic hand wash and health care personnel hand wash.