Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H14O |
| Molecular Weight | 150.2179 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)c1ccc(C)cc1O
InChI
InChIKey=MGSRCZKZVOBKFT-UHFFFAOYSA-N
InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3
Thymol, a monoterpene, obtained from thyme oil or other volatile oils, is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions to help reduce and prevent plaque and gingivitis. Recently was shown, that this substance was able to significantly reduce the oxidative stress associated with cataract. The results suggested that thymol might be a potential therapeutic approach in the prevention of diabetic complications through its aldose reductase enzyme inhibitory and antioxidant activities.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Studies on antimicrobial activity of extracts from thyme]. | 2001 Aug |
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| The efficiency of dentine adhesives in treating non-caries cervical lesions. | 2001 Dec |
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| Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver. | 2001 Nov |
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| [Analysis of flavonoids in the flowers and leaves of Monarda didyma L]. | 2002 |
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| Interdental mutans streptococci suppression in vivo: a comparison of different chlorhexidine regimens in relation to restorative material. | 2002 Apr |
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| Comparison of release mechanisms for botanical oils to control Varroa destructor (Acari: Varroidae) and Acarapis woodi (acari: Tarsonemidae) in colonies of honey bees (Hymenoptera: Apidae). | 2002 Apr |
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| Pseudomonas aeruginosa cells adapted to benzalkonium chloride show resistance to other membrane-active agents but not to clinically relevant antibiotics. | 2002 Apr |
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| Extraction of thymol, eucalyptol, menthol, and camphor residues from honey and beeswax. Determination by gas chromatography with flame ionization detection. | 2002 Apr 19 |
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| Determination of acaricides in honey by high-performance liquid chromatography with photodiode array detection. | 2002 Apr 19 |
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| Microleakage of amalgam cavity treatment systems: an in vitro evaluation. | 2002 Aug |
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| Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol. | 2002 Aug |
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| Development of a paw paw herbal shampoo for the removal of head lice. | 2002 Dec |
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| A direct continuous pH-spectrophotometric assay for arginine kinase activity. | 2002 Dec |
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| Repellent activities of essential oils and monoterpenes against Culex pipiens pallens. | 2002 Dec |
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| Detection and stability of Japanese encephalitis virus RNA and virus viability in dead infected mosquitoes under different storage conditions. | 2002 Dec |
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| Thermal and photochemical rearrangement of bicyclo[3.1.0]hex-3-en-2-one to the ketonic tautomer of phenol. Computational evidence for the formation of a diradical rather than a zwitterionic intermediate. | 2002 Dec 25 |
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| Saline or Hartmann's solution: is it still a controversy? | 2002 Feb |
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| Systemic availability and pharmacokinetics of thymol in humans. | 2002 Jul |
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| Composition and antimicrobial activity of essential oil and hexane-ether extract of Tanacetum santolinoides (dc.) Feinbr. and Fertig. | 2002 Jul-Aug |
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| Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.). | 2002 Jun |
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| Isolation and structure elucidation of radical scavengers from Thymus vulgaris leaves. | 2002 Jun |
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| Micro-phase sorbent extraction for trace analysis via in situ sorbent formation: application to the preconcentration and the spectrophotometric determination of trace ammonia. | 2002 Jun |
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| A comparative study of apical leakage of Endomethasone, Top Seal, and Roeko Seal sealer cements. | 2002 Jun |
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| Effect of Er:YAG laser on adhesion of root canal sealers. | 2002 Mar |
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| Aspergillus flavus dose-response curves to selected natural and synthetic antimicrobials. | 2002 Mar |
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| Two in vitro models for gas-phase exposure to volatile compounds. | 2002 Mar-Apr |
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| In vitro antifungal activity of several antimicrobial compounds against Penicillium expansum. | 2002 May |
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| Effects of thymol on calcium and potassium currents in canine and human ventricular cardiomyocytes. | 2002 May |
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| Insecticidal properties of essential plant oils against the mosquito Culex pipiens molestus (Diptera: Culicidae). | 2002 May |
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| The cellular compatibility of five endodontic sealers during the setting period. | 2002 Nov |
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| Long-term cytocompatibility of various endodontic sealers using a new root canal model. | 2002 Nov |
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| New diacylated 2-hydroxythymol derivatives from Melampodium divaricatum. | 2002 Nov-Dec |
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| The effectiveness of four-cavity treatment systems in sealing amalgam restorations. | 2002 Nov-Dec |
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| Surgical management of overfilling of the root canal: a case report. | 2002 Oct |
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| Inhibition of calculus formation by dentifrice formulations containing essential oils and zinc. | 2002 Oct |
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| Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. | 2002 Oct |
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| Effectiveness of chlorhexidine-thymol varnish for caries reduction in permanent first molars of 6-7-year-old children: 24-month clinical trial. | 2002 Oct |
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| Spectrophotometric determination of vitamin B1 in a pharmaceutical formulation using triphenylmethane acid dyes. | 2002 Oct 15 |
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| Influence of irrigants on the coronal microleakage of laterally condensed gutta-percha root fillings. | 2002 Sep |
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| The effects of the combination of chlorhexidine/thymol- and fluoride-containing varnishes on the severity of root caries lesions in frail institutionalised elderly people. | 2002 Sep-Nov |
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| Effect of Cervitec on mutans streptococci in plaque and on caries formation on occlusal fissures of erupting permanent molars. | 2002 Sep-Oct |
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| Effect of chlorhexidine varnish and gel on mutans streptococci in margins of restorations in adults. | 2002 Sep-Oct |
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| Antifungal activity of essential oils evaluated by two different application techniques against rye bread spoilage fungi. | 2003 |
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| Ethnobotany and natural products: the search for new molecules, new treatments of old diseases or a better understanding of indigenous cultures? | 2003 |
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| Activity and mechanisms of action of selected biocidal agents on Gram-positive and -negative bacteria. | 2003 |
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| Bacterial susceptibility to and chemical composition of essential oils from Thymus kotschyanus and Thymus persicus. | 2003 Apr 9 |
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| Antimicrobial activity and chemical composition of the essential oil of Lippia graveolens from Guatemala. | 2003 Jan |
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| Effect of thermocycling on the shear bond strength of a cyanoacrylate orthodontic adhesive. | 2003 Jan |
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| Antimicrobial and antioxidant activity of the essential oil and methanol extracts of Thymus pectinatus Fisch. et Mey. Var. pectinatus (Lamiaceae). | 2003 Jan 1 |
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| Analysis of pesticide residues on museum objects repatriated to the Hupa tribe of California. | 2003 Mar 15 |
Patents
Sample Use Guides
Rinse full strength for 30 seconds with 20 mL (2/3 fluid ounce or 4 teaspoonfuls) morning and night. Do not swallow.
Route of Administration:
Other
Thymol significantly inhibited goat lens aldose reductase (AR) enzyme in a linear manner in concentrations ranging from 0.25 to 2 µg/ml. The highest percent inhibition exhibited by thymol was 80% at 2 µg/ml and the IC50 was found to be 0.65 µg/ml. Quercetin, used as standard, inhibited 64.64% of AR enzyme at a concentration of 4.5 µg/ml.
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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CFR |
21 CFR 310.544
Created by
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NCI_THESAURUS |
C28394
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DSLD |
3396 (Number of products:5)
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JECFA EVALUATION |
THYMOL
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admin on Fri Jun 25 21:09:47 UTC 2021 , Edited by admin on Fri Jun 25 21:09:47 UTC 2021
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CFR |
21 CFR 310.531
Created by
admin on Fri Jun 25 21:09:47 UTC 2021 , Edited by admin on Fri Jun 25 21:09:47 UTC 2021
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CFR |
21 CFR 172.515
Created by
admin on Fri Jun 25 21:09:47 UTC 2021 , Edited by admin on Fri Jun 25 21:09:47 UTC 2021
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WHO-VATC |
QP53AX22
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EPA PESTICIDE CODE |
80402
Created by
admin on Fri Jun 25 21:09:47 UTC 2021 , Edited by admin on Fri Jun 25 21:09:47 UTC 2021
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| Code System | Code | Type | Description | ||
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C77062
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PRIMARY | |||
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3J50XA376E
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PRIMARY | |||
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THYMOL
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PRIMARY | |||
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89-83-8
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PRIMARY | |||
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M10824
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PRIMARY | Merck Index | ||
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1667213
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PRIMARY | USP-RS | ||
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DB02513
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PRIMARY | |||
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SUB15555MIG
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PRIMARY | |||
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866
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PRIMARY | |||
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4258
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PRIMARY | |||
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D013943
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PRIMARY | |||
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201-944-8
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89-83-8
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10553
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PRIMARY | RxNorm | ||
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CHEMBL29411
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6989
Created by
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ACTIVE MOIETY
