Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H14O |
| Molecular Weight | 150.2176 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)C1=CC=C(C)C=C1O
InChI
InChIKey=MGSRCZKZVOBKFT-UHFFFAOYSA-N
InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3
| Molecular Formula | C10H14O |
| Molecular Weight | 150.2176 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Thymol, a monoterpene, obtained from thyme oil or other volatile oils, is used as a stabilizer in pharmaceutic preparations. It has been used for its antiseptic, antibacterial, and antifungal actions to help reduce and prevent plaque and gingivitis. Recently was shown, that this substance was able to significantly reduce the oxidative stress associated with cataract. The results suggested that thymol might be a potential therapeutic approach in the prevention of diabetic complications through its aldose reductase enzyme inhibitory and antioxidant activities.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P15121 Gene ID: 231.0 Gene Symbol: AKR1B1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28216950 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
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| Preventing | Unknown Approved UseUnknown |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Bacterial susceptibility to and chemical composition of essential oils from Thymus kotschyanus and Thymus persicus. | 2003-04-09 |
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| Analysis of pesticide residues on museum objects repatriated to the Hupa tribe of California. | 2003-03-15 |
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| New diacylated 2-hydroxythymol derivatives from Melampodium divaricatum. | 2003-02-04 |
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| The effects of the combination of chlorhexidine/thymol- and fluoride-containing varnishes on the severity of root caries lesions in frail institutionalised elderly people. | 2003-01-30 |
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| Antimicrobial and antioxidant activity of the essential oil and methanol extracts of Thymus pectinatus Fisch. et Mey. Var. pectinatus (Lamiaceae). | 2003-01-01 |
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| Antimicrobial activity and chemical composition of the essential oil of Lippia graveolens from Guatemala. | 2003-01 |
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| Effect of thermocycling on the shear bond strength of a cyanoacrylate orthodontic adhesive. | 2003-01 |
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| Antifungal activity of essential oils evaluated by two different application techniques against rye bread spoilage fungi. | 2003 |
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| Ethnobotany and natural products: the search for new molecules, new treatments of old diseases or a better understanding of indigenous cultures? | 2003 |
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| Activity and mechanisms of action of selected biocidal agents on Gram-positive and -negative bacteria. | 2003 |
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| Thermal and photochemical rearrangement of bicyclo[3.1.0]hex-3-en-2-one to the ketonic tautomer of phenol. Computational evidence for the formation of a diradical rather than a zwitterionic intermediate. | 2002-12-25 |
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| Development of a paw paw herbal shampoo for the removal of head lice. | 2002-12 |
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| A direct continuous pH-spectrophotometric assay for arginine kinase activity. | 2002-12 |
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| Repellent activities of essential oils and monoterpenes against Culex pipiens pallens. | 2002-12 |
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| Detection and stability of Japanese encephalitis virus RNA and virus viability in dead infected mosquitoes under different storage conditions. | 2002-12 |
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| The effectiveness of four-cavity treatment systems in sealing amalgam restorations. | 2002-11-05 |
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| The cellular compatibility of five endodontic sealers during the setting period. | 2002-11 |
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| Long-term cytocompatibility of various endodontic sealers using a new root canal model. | 2002-11 |
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| Effect of Cervitec on mutans streptococci in plaque and on caries formation on occlusal fissures of erupting permanent molars. | 2002-10-26 |
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| Effect of chlorhexidine varnish and gel on mutans streptococci in margins of restorations in adults. | 2002-10-26 |
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| Spectrophotometric determination of vitamin B1 in a pharmaceutical formulation using triphenylmethane acid dyes. | 2002-10-15 |
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| Surgical management of overfilling of the root canal: a case report. | 2002-10 |
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| Inhibition of calculus formation by dentifrice formulations containing essential oils and zinc. | 2002-10 |
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| Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. | 2002-10 |
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| Effectiveness of chlorhexidine-thymol varnish for caries reduction in permanent first molars of 6-7-year-old children: 24-month clinical trial. | 2002-10 |
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| Composition and antimicrobial activity of essential oil and hexane-ether extract of Tanacetum santolinoides (dc.) Feinbr. and Fertig. | 2002-09-21 |
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| Influence of irrigants on the coronal microleakage of laterally condensed gutta-percha root fillings. | 2002-09 |
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| Microleakage of amalgam cavity treatment systems: an in vitro evaluation. | 2002-08 |
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| Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol. | 2002-08 |
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| Non-invasive localization of thymol accumulation in Carum copticum (Apiaceae) fruits by chemical shift selective magnetic resonance imaging. | 2002-08 |
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| QSAR evaluation of monoterpenoids' insecticidal activity. | 2002-07-31 |
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| Influence of the spatulation of two zinc oxide-eugenol-based sealers on the obturation of lateral canals. | 2002-07-20 |
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| GC/MS evaluation of thyme (Thymus vulgaris L.) oil composition and variations during the vegetative cycle. | 2002-07-20 |
|
| Systemic availability and pharmacokinetics of thymol in humans. | 2002-07 |
|
| Modified Class II open sandwich restorations: evaluation of interfacial adaptation and influence of different restorative techniques. | 2002-06 |
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| Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.). | 2002-06 |
|
| Isolation and structure elucidation of radical scavengers from Thymus vulgaris leaves. | 2002-06 |
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| Micro-phase sorbent extraction for trace analysis via in situ sorbent formation: application to the preconcentration and the spectrophotometric determination of trace ammonia. | 2002-06 |
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| A comparative study of apical leakage of Endomethasone, Top Seal, and Roeko Seal sealer cements. | 2002-06 |
|
| In vitro antifungal activity of several antimicrobial compounds against Penicillium expansum. | 2002-05 |
|
| Effects of thymol on calcium and potassium currents in canine and human ventricular cardiomyocytes. | 2002-05 |
|
| Insecticidal properties of essential plant oils against the mosquito Culex pipiens molestus (Diptera: Culicidae). | 2002-05 |
|
| Two in vitro models for gas-phase exposure to volatile compounds. | 2002-04-25 |
|
| Extraction of thymol, eucalyptol, menthol, and camphor residues from honey and beeswax. Determination by gas chromatography with flame ionization detection. | 2002-04-19 |
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| Determination of acaricides in honey by high-performance liquid chromatography with photodiode array detection. | 2002-04-19 |
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| Interdental mutans streptococci suppression in vivo: a comparison of different chlorhexidine regimens in relation to restorative material. | 2002-04 |
|
| Comparison of release mechanisms for botanical oils to control Varroa destructor (Acari: Varroidae) and Acarapis woodi (acari: Tarsonemidae) in colonies of honey bees (Hymenoptera: Apidae). | 2002-04 |
|
| Effect of Er:YAG laser on adhesion of root canal sealers. | 2002-03 |
|
| [Analysis of flavonoids in the flowers and leaves of Monarda didyma L]. | 2002 |
|
| [Studies on antimicrobial activity of extracts from thyme]. | 2001-08 |
Patents
Sample Use Guides
Rinse full strength for 30 seconds with 20 mL (2/3 fluid ounce or 4 teaspoonfuls) morning and night. Do not swallow.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28216950
Thymol significantly inhibited goat lens aldose reductase (AR) enzyme in a linear manner in concentrations ranging from 0.25 to 2 µg/ml. The highest percent inhibition exhibited by thymol was 80% at 2 µg/ml and the IC50 was found to be 0.65 µg/ml. Quercetin, used as standard, inhibited 64.64% of AR enzyme at a concentration of 4.5 µg/ml.
| Substance Class |
Chemical
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3J50XA376E
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Validated (UNII)
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CFR |
21 CFR 310.544
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NCI_THESAURUS |
C28394
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DSLD |
3396 (Number of products:5)
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JECFA EVALUATION |
THYMOL
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CFR |
21 CFR 310.531
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CFR |
21 CFR 172.515
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WHO-VATC |
QP53AX22
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EPA PESTICIDE CODE |
80402
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C77062
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3J50XA376E
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27607
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11215
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THYMOL
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89-83-8
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m10824
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DB02513
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47821
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SUB15555MIG
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100000091776
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3J50XA376E
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866
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4258
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D013943
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1667213
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588
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201-944-8
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DTXSID6034972
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10553
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CHEMBL29411
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49142
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6989
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| Related Record | Type | Details | ||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Compound measured as 4.30% of the composition of the steam distillate of Elymus repens rhizome as per R Boesel in Planta Medica iss:4 pg:399-400, 1989.
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Pure compound identified in the Paeonia lactiflora (Paeoniaceae) root steam distillate with growth-inhibiting activity against nine harmful intestinal bacteria and eight lactic acid-producing bacteria.
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |