FLUOROSALAN

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H8Br2F3NO2
Molecular Weight	439.022
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C(C=C(Br)C=C1Br)C(=O)NC2=CC=CC(=C2)C(F)(F)F

InChI

InChIKey=VYKKDKFTDMVOBU-UHFFFAOYSA-N

InChI=1S/C14H8Br2F3NO2/c15-8-5-10(12(21)11(16)6-8)13(22)20-9-3-1-2-7(4-9)14(17,18)19/h1-6,21H,(H,20,22)

HIDE SMILES / InChI

Description
Sources: Disinfection, Sterilization, and Preservation. page 406 | https://books.google.ru/books?id=3f-kPJ17_TYC&pg=PA406&lpg=PA406&dq=FLUOROSALAN+fda&source=bl&ots=KmGjIy4QL2&sig=gNaoNYJAStt8dgUxWHLyu7wtzR8&hl=ru&sa=X&ved=0ahUKEwjeivWAjK_OAhWGHpoKHQ0lBVEQ6AEIJDAB#v=onepage&q=FLUOROSALAN%20fda&f=false
Curator's Comment: description was created based on several sources, including https://www.federalregister.gov/articles/2015/05/01/2015-10174/safety-and-effectiveness-of-health-care-antiseptics-topical-antimicrobial-drug-products-for

Antimicrobial agent Fluorosalan is classified as Category II for use as antiseptic handwash, healthcare personnel handwash, patient preoperative skin preoperative skin preparation, and surgical hand scrub products. In the 1994 TFM (59 FR 31402 at 31435-31436), FDA proposed that the active ingredient fluorosalan be found not GRAS/GRAE for the uses referred to in the 1994 TFM as antiseptic hand wash and health care personnel hand wash.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY556031	https://www.001chemical.com/chem/4776-06-1
3B Scientific (Wuhan) Corp	3B2-4283	http://www.3bsc.com/index/pro_info.php?id=126829
ABI Chem	AC1L2H7X
Alfa Chemistry	1050591	https://www.alfa-chemistry.com/cas_4776-06-1.htm
ChemMol	99096467	http://www.chemmol.com/chemmol/99096467.html
ChemTik	CTK5I6206
Chemspace	CSSB00025760325	https://chem-space.com/CSSB00025760325
Compound Cloud	20906
Finetech	FT-0750585	http://www.finetechnology-ind.com/prod/detail/pub/4776-06-1.html
MP Biomedicals	227119
Molcore	MC556031	https://www.molcore.com/product/4776-06-1
MuseChem	R035563
NCI Plated 2007	166520
NovoSeek	20906
Smolecule	S569725	https://www.smolecule.com/products/s569725
THE BioTek	bt-288803	https://www.thebiotek.com/product/others/bt-288803
THE BioTek	bt-425770	https://www.thebiotek.com/product/others/bt-425770
Tetrahedron	TS70305
Toronto Research Chemicals	F595065
ZINC	ZINC000000537744	http://zinc15.docking.org/substances/ZINC000000537744

PubMed

Title	Date	PubMed
Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action.	2010 May 1	20067776

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

The intracellular ATP content of two human cervical cancer cell lines, ME180 and HeLa, was measured after the treatment of the compounds for 5–72 h. After 5 h treatment, Fluorosalan showed no inhibitory effect on cell growth. After 24–72 h treatment, Fluorosalan significantly inhibited the growth of ME180 cells (IC50 24h: 9.0uM, 48h: 2.7uM, 72h: 1.3uM) and HeLa (IC50 24h: 3.1uM, 48h: 2.1uM, 72h: 3.3uM).

Name

Type

Language

FLUOROSALAN

Official Name

English

FLUSALAN

Official Name

English

3,5-DIBROMO-3'-(TRIFLUOROMETHYL)SALICYLANILIDE

Systematic Name

English

flusalan [INN]

Common Name

English

FLUOROSALAN [MI]

Common Name

English

3,5-DIBROMO-.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-SALICYLOTOLUIDIDE

Common Name

English

NSC-166520

Code

English

FLUOROSALAN [INCI]

Common Name

English

BENZAMIDE, 3,5-DIBROMO-2-HYDROXY-N-(3-(TRIFLUOROMETHYL)PHENYL)-

Systematic Name

English

FLUOROSALAN [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394