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Details

Stereochemistry ACHIRAL
Molecular Formula C14H8Br2F3NO2
Molecular Weight 439.022
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLUOROSALAN

SMILES

OC1=C(C=C(Br)C=C1Br)C(=O)NC2=CC=CC(=C2)C(F)(F)F

InChI

InChIKey=VYKKDKFTDMVOBU-UHFFFAOYSA-N
InChI=1S/C14H8Br2F3NO2/c15-8-5-10(12(21)11(16)6-8)13(22)20-9-3-1-2-7(4-9)14(17,18)19/h1-6,21H,(H,20,22)

HIDE SMILES / InChI

Description

Antimicrobial agent Fluorosalan is classified as Category II for use as antiseptic handwash, healthcare personnel handwash, patient preoperative skin preoperative skin preparation, and surgical hand scrub products. In the 1994 TFM (59 FR 31402 at 31435-31436), FDA proposed that the active ingredient fluorosalan be found not GRAS/GRAE for the uses referred to in the 1994 TFM as antiseptic hand wash and health care personnel hand wash.

Originator

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
The intracellular ATP content of two human cervical cancer cell lines, ME180 and HeLa, was measured after the treatment of the compounds for 5–72 h. After 5 h treatment, Fluorosalan showed no inhibitory effect on cell growth. After 24–72 h treatment, Fluorosalan significantly inhibited the growth of ME180 cells (IC50 24h: 9.0uM, 48h: 2.7uM, 72h: 1.3uM) and HeLa (IC50 24h: 3.1uM, 48h: 2.1uM, 72h: 3.3uM).