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Details

Stereochemistry ACHIRAL
Molecular Formula CHI3
Molecular Weight 393.7321
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IODOFORM

SMILES

IC(I)I

InChI

InChIKey=OKJPEAGHQZHRQV-UHFFFAOYSA-N
InChI=1S/CHI3/c2-1(3)4/h1H

HIDE SMILES / InChI
Molecular Formula CHI3
Molecular Weight 393.7321
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/24676583 | https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~SML54M:1:ther | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=48a893ae-1456-43c2-8924-a8aed705ae4f&type=display

Iodoform is an organic compound with the formula CHI3. It was formerly used as an antiseptic wound powder. Iodoform is commonly used as radiopacifier for primary tooth root canal fllling, but its use in endodontics is controversial because of its potential for causing toxic effects. It is also used in veterinary medicine as an active ingredient in the ear powders for dogs and cats.

CNS Activity

CNS Active
4002
Curator's Comment: Potential symptoms of overexposure are irritation of eyes and skin; lightheadedness, dizziness, nausea, incoordination, CNS depression; dyspnea; liver, kidney and heart damage; visual disturbances.

Originator

Approval Year

1921
1468
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Not Provided
511
Vitapex

Approved Use

Vitapex is a premixed calcium hydroxide paste containing iodoform used as a temporary or permanent root canal filling material after pulpectomy.
Primary
Not Provided
511
PETCO

Approved Use

PETCO Ear Powder gives prompt relief from irritated, itching ears of non-parasitic origin. It stops scratching and aids in the inhibition of bacterial growth. Eliminates unpleasant ear odors. PETCO Ear Powder dries ear discharge and makes it easy to remove.
PubMed

PubMed

TitleDatePubMed
Serratia marcescens causing cervical necrotizing oropharyngitis.
2009-03
The effectiveness of different thickness of mineral trioxide aggregate on coronal leakage in endodontically treated deciduous teeth.
2008-12-02
Reconstruction of a huge oral maxillofacial defect caused by necrotic fasciitis secondary to leukaemia.
2008-12
Occurrence and mammalian cell toxicity of iodinated disinfection byproducts in drinking water.
2008-11-15
Severe iatrogenic bismuth poisoning with bismuth iodoform paraffin paste treated with DMPS chelation.
2008-11
The classic: ankylosis: arthroplasty--clinical and experimental. 1905.
2008-11
An agar diffusion comparison of the antimicrobial effect of calcium hydroxide at five different concentrations with three different vehicles.
2008-10
Recurrent trauma histories of two 'unlucky teeth': 42-month follow-up.
2008-10
Success of pulpectomy with zinc oxide-eugenol vs calcium hydroxide/iodoform paste in primary molars: a clinical study.
2008-09-05
The use of free osteoplasty together with trials on arthrodesis and joint transplantation. Archiv für klin Chirurgie. 1908;86(4):939-954.
2008-08
Reduction of lead oxide (PbO2) by iodide and formation of iodoform in the PbO2/I(-)/NOM system.
2008-04-15
A survey of primary tooth pulp therapy as taught in US dental schools and practiced by diplomates of the American Board Of Pediatric Dentistry.
2008-04-12
Avoidance of BIPP allergy hypersensitivity reactions following ear surgery.
2008-02
Ability of root canal antiseptics used in dental practice to induce chromosome aberrations in human dental pulp cells.
2008-01-08
Sublingual ranula: a closer look to its surgical management.
2008-01
Wound healing process of injured pulp tissues with emdogain gel.
2008-01
Effect of repeated simulated disinfections by microwave energy on the complete denture base adaptation.
2008
Effect of the simulated disinfection by microwave energy on the impact strength of the tooth/acrylic resin adhesion.
2008
Antimicrobial effect and pH of chlorhexidine gel and calcium hydroxide alone and associated with other materials.
2008
Cytotoxicity, histopathological, microbiological and clinical aspects of an endodontic iodoform-based paste used in pediatric dentistry: a review.
2008
Transient X-ray diffraction reveals global and major reaction pathways for the photolysis of iodoform in solution.
2008
Determination of the minimum inhibitory concentration of four medicaments used as intracanal medication.
2007-12
Walter Whitehead: A brief history of the man and his varnish.
2007-12
Incision and drainage followed by mattress suture repair of auricular hematoma.
2007-12
Iodoform intoxication; a case report of prolonged consciousness disturbance in a patient with a high plasma iodine level.
2007-11
Whitehead's varnish nasal pack.
2007-06
LC/MS quantitative study of glucose by iodine attachment.
2007-05-22
[Treatment of chronic apical periodontitis teeth complicated by open apices with Vitapex in the adults].
2007-04
Emil Behring's medical culture: from disinfection to serotherapy.
2007-04
Comparison of disinfection byproduct formation from chlorine and alternative disinfectants.
2007-04
[Survey of the current situation on clinical application of root canal treatments in Zhejiang province].
2007-02
[Antimicrobial activity of nano-hydroxyapatite/polyamide 66 as a pulp capping agent in vitro].
2007-02
Biocompatibility of various formula root filling materials for primary teeth.
2007-02
Impact of a biological barrier in pulpectomies of primary molars.
2007-01-26
[Clinical analysis of cleft lip and palate repair at the same time on 468 infants].
2007-01
Effect of a topical antimicrobial paste on healing after extraction of molars in HIV positive patients: randomised controlled clinical trial.
2007-01
Evaluation of antimicrobial efficacy of various root canal filling materials used in primary teeth: a microbiological study.
2007
Vibrational relaxation of C-D stretching vibrations in CDCl3, CDBr3, and CDI3.
2006-11-07
Evaluation of antimicrobial and antifungal effects of iodoform-integrating gutta-percha.
2006-10
Efficacy of propolis as an intracanal medicament against Enterococcus faecalis.
2006-09-29
Evaluation of tissue response to MTA and Portland cement with iodoform.
2006-09
[Clinical study of repair the defect of immediate implant by acellular dermal matrix].
2006-03
Is there life after Buckley's Formocresol? Part I -- a narrative review of alternative interventions and materials.
2006-03
Antimicrobial efficacy of medicated root canal filling materials.
2006-02
Influence of iodoform on antimicrobial potential of calcium hydroxide.
2006-01
Antimicrobial analysis of different root canal filling pastes used in pediatric dentistry by two experimental methods.
2006
[Preliminary evaluation of the clinical results of calcium phosphorate cement root canal sealer].
2005-12
[The effectiveness of some methods in eliminating bacteria from the root canal of a tooth with chronic apical periodontitis].
2005
Management of a root fracture in an immature permanent tooth.
2005
Temporary stupor in a patient treated with iodoform gauze for mediastinitis after coronary artery bypass grafting.
2004-06
Patents

Patents

07799773
2
08101775
1
08115023
1
08802881
1

Sample Use Guides

In Vivo Use Guide
The fatal dose of iodoform is estimated to be 2 g.
Route of Administration: Transdermal
In Vitro Use Guide
The objective of the study was to assess, in vitro, the effectiveness of several concentrations (0.22 gm/ml, 0.022 gm/ml, 0.0022 gm/ml) of Metapex (calcium hydroxide with iodoform formulation) in the elimination of selected microorganisms: Enterococcus faecalis, Candida albicans, Bacteroides fragilis and Propionibacterium acne, respectivelly. There was significant reduction in growth inhibition of P. acne, as the concentration of Metapex decreases. At lower concentrations of Metapex there was no growth inhibition observed against E. faecalis, C. albicans and B. fragilis. The result of the study suggested that Metapex is a potent antimicrobial agent at higher concentration.
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:36:26 GMT 2025
Edited
by admin
on Mon Mar 31 17:36:26 GMT 2025
Record UNII
KXI2J76489
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IODOFORM
HSDB   INCI   MART.   MI   USP   WHO-DD  
INCI  
Official Name English
IODOFORMUM
HPUS  
Preferred Name English
IODOFORM [USP MONOGRAPH]
Common Name English
IODOFORM [JAN]
Common Name English
IODOFORMUM [HPUS]
Common Name English
IODOFORM [HSDB]
Common Name English
TRIIODOMETHANE
Systematic Name English
IODOFORM [MART.]
Common Name English
IODOFORM [MI]
Common Name English
NSC-26251
Code English
Iodoform [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-VATC QD09AA13
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
NCI_THESAURUS C28394
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
WHO-ATC D09AA13
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
Code System Code Type Description
RXCUI
27748
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY RxNorm
WIKIPEDIA
IODOFORM
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
SMS_ID
100000077377
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
HSDB
4099
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
MERCK INDEX
m6346
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY Merck Index
CHEBI
37758
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PRIMARY
ChEMBL
CHEMBL1451116
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
EVMPD
SUB14246MIG
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
MESH
C010473
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
FDA UNII
KXI2J76489
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
ECHA (EC/EINECS)
200-874-5
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
NCI_THESAURUS
C77050
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
DAILYMED
KXI2J76489
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
NSC
26251
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
EPA CompTox
DTXSID4020743
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
CAS
75-47-8
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
DRUG BANK
DB13813
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
PUBCHEM
6374
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
DRUG CENTRAL
4579
Created by admin on Mon Mar 31 17:36:26 GMT 2025 , Edited by admin on Mon Mar 31 17:36:26 GMT 2025
PRIMARY
Related Record Type Details
Structure of IODOFORM
ACTIVE MOIETY
NIH
NCATS
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