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Primary Target

chloride transport

5

Histamine H1 receptor

315

Dopamine D2 receptor

297

DNA

278

Bacterial penicillin-binding protein

233

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Other

4

US Approved Rx

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Approved

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Approval Year

Unknown

4

1960

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Condition

Edema

1

Hypertension

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Treatment Modality

Palliative

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Substance Class

Chemical

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Mixture

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FDA UNII

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CAS

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PUBCHEM

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CHEBI

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EPA CompTox

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CARDIOVASCULAR SYSTEM

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ATC Level 2

DIURETICS

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ATC Level 3

DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION

1

LOW-CEILING DIURETICS, EXCL. THIAZIDES

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ATC Level 4

Low-ceiling diuretics and potassium-sparing agents

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Sulfonamides and potassium in combination

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Sulfonamides, plain

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Salts, Hydrates, Esters, etc.

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Principal Form

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Showing 1 - 5 of 5 results

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CHLORTHALIDONE

Q0MQD1073Q

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Status:

US Approved Rx (1984)

First approved in 1960

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

chloride transport

renal sodium excretion

Conditions:

Chlorthalidone is a diuretic that is used for the treatment of hypertansion and edema. The drug is approved by FDA and either prescribed alone (Chlorthalidone trade name) or in combination with atenolol (Tenoretic trade name), azilsartan kamedoxomil ...

(Edarbyclor) and clonidin (Clorpres). The mechanism of action is associated with activation of sodium and chloride renal excretion.

4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID, (E)-

Q1O6DSW23R

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

H(+)/Cl(-) exchange transporter 7

P2X purinoceptor 3

chloride transport

DISODIUM 4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONATE, (E)-

1VFRQ7416A

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

H(+)/Cl(-) exchange transporter 7

P2X purinoceptor 3

chloride transport

4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID, (Z)-

AA0P575P6L

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

H(+)/Cl(-) exchange transporter 7

P2X purinoceptor 3

chloride transport

4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID

QHR3Z2PN8M

Status:

Other

Class:

MIXTURE

Targets:

H(+)/Cl(-) exchange transporter 7

P2X purinoceptor 3

chloride transport

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