Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H10N2O6S4 |
Molecular Weight | 454.52 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 3 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OS(=O)(=O)C1=C(C=CC(=C1)N=C=S)\C=C/C2=C(C=C(C=C2)N=C=S)S(O)(=O)=O
InChI
InChIKey=YSCNMFDFYJUPEF-UPHRSURJSA-N
InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1-
Molecular Formula | C16H10N2O6S4 |
Molecular Weight | 454.52 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 3 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2998 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12213051 |
1.0 µM [IC50] | ||
Target ID: GO:0006821 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3783658 |
2.0 µM [Ki] | ||
Target ID: P51798 Gene ID: 1186.0 Gene Symbol: CLCN7 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/20830208 |
39.0 µM [IC50] |
PubMed
Title | Date | PubMed |
---|---|---|
Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle. | 1991 Jul 15 |
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AE2 anion exchanger polypeptide is a homooligomer in pig gastric membranes: a chemical cross-linking study. | 1999 Jun 29 |
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Redox regulation of p53 during hypoxia. | 2000 Aug 10 |
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Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4. | 2000 Sep 29 |
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Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages. | 2002 Apr |
|
Urate transport via human PAH transporter hOAT1 and its gene structure. | 2003 Jan |
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Tumour-specific activation of the sodium/iodide symporter gene under control of the glucose transporter gene 1 promoter (GTI-1.3). | 2003 May |
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Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts. | 2004 Jul |
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Anion exchanger 2 mediates the action of arsenic trioxide. | 2006 Sep |
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Appearance of segmental discrepancy of anion transport in rat distal colon. | 2007 Aug |
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Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter. | 2007 Aug |
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Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans. | 2007 Aug |
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Activity and regulation of Na+-HCO3- cotransporter in immortalized spontaneously hypertensive rat and Wistar-Kyoto rat proximal tubular epithelial cells. | 2007 May |
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Functional ion channels in mouse bone marrow mesenchymal stem cells. | 2007 Nov |
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The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2. | 2008 Jan |
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Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells. | 2008 Sep 5 |
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Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. | 2009 Feb |
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Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis. | 2010 Dec |
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Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons. | 2010 Jan |
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Attenuating homologous recombination stimulates an AID-induced antileukemic effect. | 2013 May 6 |
|
Functional swapping between transmembrane proteins TMEM16A and TMEM16F. | 2014 Mar 14 |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 07:01:18 GMT 2023
by
admin
on
Sat Dec 16 07:01:18 GMT 2023
|
Record UNII |
AA0P575P6L
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Record Status |
Validated (UNII)
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Record Version |
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-
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AA0P575P6L
Created by
admin on Sat Dec 16 07:01:18 GMT 2023 , Edited by admin on Sat Dec 16 07:01:18 GMT 2023
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9548709
Created by
admin on Sat Dec 16 07:01:18 GMT 2023 , Edited by admin on Sat Dec 16 07:01:18 GMT 2023
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