U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H10N2O6S4
Molecular Weight 454.52
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 3
Charge 0

SHOW SMILES / InChI
Structure of 4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID, (Z)-

SMILES

OS(=O)(=O)C1=CC(=CC=C1\C=C/C2=CC=C(C=C2S(O)(=O)=O)N=C=S)N=C=S

InChI

InChIKey=YSCNMFDFYJUPEF-UPHRSURJSA-N
InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1-

HIDE SMILES / InChI

Molecular Formula C16H10N2O6S4
Molecular Weight 454.52
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 3
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
1.0 µM [IC50]
2.0 µM [Ki]
Target ID: P51798
Gene ID: 1186.0
Gene Symbol: CLCN7
Target Organism: Homo sapiens (Human)
39.0 µM [IC50]
PubMed

PubMed

TitleDatePubMed
Functional swapping between transmembrane proteins TMEM16A and TMEM16F.
2014-03-14
Attenuating homologous recombination stimulates an AID-induced antileukemic effect.
2013-05-06
Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis.
2010-12
Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.
2010-01
Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
2009-02
Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells.
2008-09-05
The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2.
2008-01
Functional ion channels in mouse bone marrow mesenchymal stem cells.
2007-11
Appearance of segmental discrepancy of anion transport in rat distal colon.
2007-08
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
2007-08
Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans.
2007-08
Activity and regulation of Na+-HCO3- cotransporter in immortalized spontaneously hypertensive rat and Wistar-Kyoto rat proximal tubular epithelial cells.
2007-05
Absorption of folate by Caco-2 cells is not affected by high glucose concentration.
2006-12-03
Anion exchanger 2 mediates the action of arsenic trioxide.
2006-09
Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1).
2006-06
Ionic currents in multidrug resistant K562 human leukemic cells.
2005-09
ATP binding cassette transporter ABC1 is required for the release of interleukin-1beta by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells.
2005-03
Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts.
2004-07
Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.
2004-06
Tumour-specific activation of the sodium/iodide symporter gene under control of the glucose transporter gene 1 promoter (GTI-1.3).
2003-05
Urate transport via human PAH transporter hOAT1 and its gene structure.
2003-01
Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages.
2002-04
Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.
2000-09-29
Redox regulation of p53 during hypoxia.
2000-08-10
AE2 anion exchanger polypeptide is a homooligomer in pig gastric membranes: a chemical cross-linking study.
1999-06-29
Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds.
1997-12-24
Chromium- and nickel-induced cytotoxicity in normal and transformed human keratinocytes: an investigation of pharmacological approaches to the prevention of Cr(VI)-induced cytotoxicity.
1996-02
Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.
1994-10
Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle.
1991-07-15
Antiviral immunotoxins: antibody-mediated delivery of gelonin inhibits Pichinde virus replication in vitro.
1991-02
Lysine 539 of human band 3 is not essential for ion transport or inhibition by stilbene disulfonates.
1989-11-25
Patents
Substance Class Chemical
Created
by admin
on Mon Mar 31 21:39:44 GMT 2025
Edited
by admin
on Mon Mar 31 21:39:44 GMT 2025
Record UNII
AA0P575P6L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID, (Z)-
Common Name English
BENZENESULFONIC ACID, 2,2'-(1Z)-1,2-ETHENEDIYLBIS(5-ISOTHIOCYANATO-
Preferred Name English
Code System Code Type Description
FDA UNII
AA0P575P6L
Created by admin on Mon Mar 31 21:39:44 GMT 2025 , Edited by admin on Mon Mar 31 21:39:44 GMT 2025
PRIMARY
PUBCHEM
9548709
Created by admin on Mon Mar 31 21:39:44 GMT 2025 , Edited by admin on Mon Mar 31 21:39:44 GMT 2025
PRIMARY