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Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
1.0 µM [IC50]
2.0 µM [Ki]
Target ID: P51798
Gene ID: 1186.0
Gene Symbol: CLCN7
Target Organism: Homo sapiens (Human)
39.0 µM [IC50]
PubMed

PubMed

TitleDatePubMed
Antiviral immunotoxins: antibody-mediated delivery of gelonin inhibits Pichinde virus replication in vitro.
1991 Feb
Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.
1994 Oct
Chromium- and nickel-induced cytotoxicity in normal and transformed human keratinocytes: an investigation of pharmacological approaches to the prevention of Cr(VI)-induced cytotoxicity.
1996 Feb
Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds.
1997 Sep-Oct
Redox regulation of p53 during hypoxia.
2000 Aug 10
Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.
2000 Sep 29
Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages.
2002 Apr
Urate transport via human PAH transporter hOAT1 and its gene structure.
2003 Jan
Tumour-specific activation of the sodium/iodide symporter gene under control of the glucose transporter gene 1 promoter (GTI-1.3).
2003 May
Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts.
2004 Jul
Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.
2004 Jun
ATP binding cassette transporter ABC1 is required for the release of interleukin-1beta by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells.
2005 Mar
Ionic currents in multidrug resistant K562 human leukemic cells.
2005 Sep
Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1).
2006 Jun
Anion exchanger 2 mediates the action of arsenic trioxide.
2006 Sep
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
2007 Aug
Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans.
2007 Aug
Activity and regulation of Na+-HCO3- cotransporter in immortalized spontaneously hypertensive rat and Wistar-Kyoto rat proximal tubular epithelial cells.
2007 May
Functional ion channels in mouse bone marrow mesenchymal stem cells.
2007 Nov
The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2.
2008 Jan
Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells.
2008 Sep 5
Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
2009 Feb
Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.
2010 Jan
Functional swapping between transmembrane proteins TMEM16A and TMEM16F.
2014 Mar 14
Patents
Substance Class Mixture
Created
by admin
on Sat Dec 16 07:01:18 GMT 2023
Edited
by admin
on Sat Dec 16 07:01:18 GMT 2023
Record UNII
QHR3Z2PN8M
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID
Common Name English
2,2'-(1,2-ETHENEDIYL)BIS(5-ISOTHIOCYANATOBENZENESULFONIC ACID)
Common Name English
DIDS
MI  
Common Name English
DIDS [MI]
Common Name English
Code System Code Type Description
CAS
53005-05-3
Created by admin on Sat Dec 16 07:01:19 GMT 2023 , Edited by admin on Sat Dec 16 07:01:19 GMT 2023
PRIMARY
MERCK INDEX
m4383
Created by admin on Sat Dec 16 07:01:19 GMT 2023 , Edited by admin on Sat Dec 16 07:01:19 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
DIDS
Created by admin on Sat Dec 16 07:01:19 GMT 2023 , Edited by admin on Sat Dec 16 07:01:19 GMT 2023
PRIMARY
FDA UNII
QHR3Z2PN8M
Created by admin on Sat Dec 16 07:01:19 GMT 2023 , Edited by admin on Sat Dec 16 07:01:19 GMT 2023
PRIMARY
CHEBI
4286
Created by admin on Sat Dec 16 07:01:19 GMT 2023 , Edited by admin on Sat Dec 16 07:01:19 GMT 2023
PRIMARY
Definition References