U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
1.0 µM [IC50]
2.0 µM [Ki]
Target ID: P51798
Gene ID: 1186.0
Gene Symbol: CLCN7
Target Organism: Homo sapiens (Human)
39.0 µM [IC50]
PubMed

PubMed

TitleDatePubMed
Lysine 539 of human band 3 is not essential for ion transport or inhibition by stilbene disulfonates.
1989 Nov 25
Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.
1994 Oct
Chromium- and nickel-induced cytotoxicity in normal and transformed human keratinocytes: an investigation of pharmacological approaches to the prevention of Cr(VI)-induced cytotoxicity.
1996 Feb
Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds.
1997 Sep-Oct
AE2 anion exchanger polypeptide is a homooligomer in pig gastric membranes: a chemical cross-linking study.
1999 Jun 29
Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts.
2004 Jul
Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.
2004 Jun
ATP binding cassette transporter ABC1 is required for the release of interleukin-1beta by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells.
2005 Mar
Appearance of segmental discrepancy of anion transport in rat distal colon.
2007 Aug
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
2007 Aug
Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans.
2007 Aug
Activity and regulation of Na+-HCO3- cotransporter in immortalized spontaneously hypertensive rat and Wistar-Kyoto rat proximal tubular epithelial cells.
2007 May
The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2.
2008 Jan
Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.
2010 Jan
Attenuating homologous recombination stimulates an AID-induced antileukemic effect.
2013 May 6
Patents
Name Type Language
4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID
Common Name English
2,2'-(1,2-ETHENEDIYL)BIS(5-ISOTHIOCYANATOBENZENESULFONIC ACID)
Common Name English
DIDS
MI  
Common Name English
DIDS [MI]
Common Name English
Code System Code Type Description
CAS
53005-05-3
Created by admin on Sat Dec 16 07:01:19 GMT 2023 , Edited by admin on Sat Dec 16 07:01:19 GMT 2023
PRIMARY
MERCK INDEX
m4383
Created by admin on Sat Dec 16 07:01:19 GMT 2023 , Edited by admin on Sat Dec 16 07:01:19 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
DIDS
Created by admin on Sat Dec 16 07:01:19 GMT 2023 , Edited by admin on Sat Dec 16 07:01:19 GMT 2023
PRIMARY
FDA UNII
QHR3Z2PN8M
Created by admin on Sat Dec 16 07:01:19 GMT 2023 , Edited by admin on Sat Dec 16 07:01:19 GMT 2023
PRIMARY
CHEBI
4286
Created by admin on Sat Dec 16 07:01:19 GMT 2023 , Edited by admin on Sat Dec 16 07:01:19 GMT 2023
PRIMARY
Definition References