4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID

Approval Year

Targets

Primary Target	Pharmacology	Potency
P2X purinoceptor 3 9 Target ID: CHEMBL2998 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12213051	Inhibitor 8504	1.0 µM [IC50]
chloride transport 5 Target ID: GO:0006821 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3783658	Inhibitor 8504	2.0 µM [Ki]
H(+)/Cl(-) exchange transporter 7 4 Target ID: P51798 Gene ID: 1186.0 Gene Symbol: CLCN7 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/20830208	Inhibitor 8504	39.0 µM [IC50]

PubMed

Title	Date	PubMed
Functional swapping between transmembrane proteins TMEM16A and TMEM16F.	2014-03-14	24478309
Attenuating homologous recombination stimulates an AID-induced antileukemic effect.	2013-05-06	23589568
Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis.	2010-12	20937774
Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.	2010-01	19815690
Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.	2009-02	19023039
Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells.	2008-09-05	18590702
The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2.	2008-01	18164246
Functional ion channels in mouse bone marrow mesenchymal stem cells.	2007-11	17699636
Appearance of segmental discrepancy of anion transport in rat distal colon.	2007-08	17666794
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.	2007-08	17475902
Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans.	2007-08	17475669
Activity and regulation of Na+-HCO3- cotransporter in immortalized spontaneously hypertensive rat and Wistar-Kyoto rat proximal tubular epithelial cells.	2007-05	17325238
Absorption of folate by Caco-2 cells is not affected by high glucose concentration.	2006-12-03	17034785
Anion exchanger 2 mediates the action of arsenic trioxide.	2006-09	17018029
Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1).	2006-06	16313995
Ionic currents in multidrug resistant K562 human leukemic cells.	2005-09	16038730
ATP binding cassette transporter ABC1 is required for the release of interleukin-1beta by P2X7-stimulated and lipopolysaccharide-primed mouse Schwann cells.	2005-03	15578659
Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts.	2004-07	15131065
Molecular determinants of differential pore blocking of kidney CLC-K chloride channels.	2004-06	15167890
Tumour-specific activation of the sodium/iodide symporter gene under control of the glucose transporter gene 1 promoter (GTI-1.3).	2003-05	12541134
Urate transport via human PAH transporter hOAT1 and its gene structure.	2003-01	12472777
Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages.	2002-04	11907163
Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.	2000-09-29	10913127
Redox regulation of p53 during hypoxia.	2000-08-10	10951577
AE2 anion exchanger polypeptide is a homooligomer in pig gastric membranes: a chemical cross-linking study.	1999-06-29	10387099
Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds.	1997-12-24	9403935
Chromium- and nickel-induced cytotoxicity in normal and transformed human keratinocytes: an investigation of pharmacological approaches to the prevention of Cr(VI)-induced cytotoxicity.	1996-02	8746330
Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.	1994-10	7530934
Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle.	1991-07-15	2071607
Antiviral immunotoxins: antibody-mediated delivery of gelonin inhibits Pichinde virus replication in vitro.	1991-02	1650165
Lysine 539 of human band 3 is not essential for ion transport or inhibition by stilbene disulfonates.	1989-11-25	2511191

Patents

Name

Type

Language

4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID

Common Name

English

DIDS	Locators: MI Sources:

Preferred Name

English

2,2'-(1,2-ETHENEDIYL)BIS(5-ISOTHIOCYANATOBENZENESULFONIC ACID)

Common Name

English

DIDS [MI]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID701027549