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Details

Stereochemistry ACHIRAL
Molecular Formula C16H10N2O6S4
Molecular Weight 454.52
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 3
Charge 0

SHOW SMILES / InChI
Structure of 4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID, (E)-

SMILES

OS(=O)(=O)C1=C(C=CC(=C1)N=C=S)\C=C\C2=C(C=C(C=C2)N=C=S)S(O)(=O)=O

InChI

InChIKey=YSCNMFDFYJUPEF-OWOJBTEDSA-N
InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+

HIDE SMILES / InChI

Molecular Formula C16H10N2O6S4
Molecular Weight 454.52
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 3
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
1.0 µM [IC50]
2.0 µM [Ki]
Target ID: P51798
Gene ID: 1186.0
Gene Symbol: CLCN7
Target Organism: Homo sapiens (Human)
39.0 µM [IC50]
PubMed

PubMed

TitleDatePubMed
Lysine 539 of human band 3 is not essential for ion transport or inhibition by stilbene disulfonates.
1989 Nov 25
Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle.
1991 Jul 15
Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.
1994 Oct
Chromium- and nickel-induced cytotoxicity in normal and transformed human keratinocytes: an investigation of pharmacological approaches to the prevention of Cr(VI)-induced cytotoxicity.
1996 Feb
Inhibition of sandfly fever Sicilian virus (Phlebovirus) replication in vitro by antiviral compounds.
1997 Sep-Oct
Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages.
2002 Apr
Urate transport via human PAH transporter hOAT1 and its gene structure.
2003 Jan
Tumour-specific activation of the sodium/iodide symporter gene under control of the glucose transporter gene 1 promoter (GTI-1.3).
2003 May
Anion exchanger 2 mediates the action of arsenic trioxide.
2006 Sep
Appearance of segmental discrepancy of anion transport in rat distal colon.
2007 Aug
Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.
2007 Aug
Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans.
2007 Aug
The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2.
2008 Jan
Pharmacologic blockade of chloride channel synergistically enhances apoptosis of chemotherapeutic drug-resistant cancer stem cells.
2008 Sep 5
Pharmacological characterization of pannexin-1 currents expressed in mammalian cells.
2009 Feb
Oligomerization of the mitochondrial protein voltage-dependent anion channel is coupled to the induction of apoptosis.
2010 Dec
Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.
2010 Jan
Attenuating homologous recombination stimulates an AID-induced antileukemic effect.
2013 May 6
Functional swapping between transmembrane proteins TMEM16A and TMEM16F.
2014 Mar 14
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 04:18:39 GMT 2023
Edited
by admin
on Sat Dec 16 04:18:39 GMT 2023
Record UNII
Q1O6DSW23R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISULFONIC ACID, (E)-
Common Name English
BENZENESULFONIC ACID, 2,2'-(1,2-ETHENEDIYL)BIS(5-ISOTHIOCYANATO-, (E)-
Common Name English
BENZENESULFONIC ACID, 2,2'-(1E)-1,2-ETHENEDIYLBIS(5-ISOTHIOCYANATO-
Common Name English
Code System Code Type Description
CAS
152216-76-7
Created by admin on Sat Dec 16 04:18:39 GMT 2023 , Edited by admin on Sat Dec 16 04:18:39 GMT 2023
PRIMARY
FDA UNII
Q1O6DSW23R
Created by admin on Sat Dec 16 04:18:39 GMT 2023 , Edited by admin on Sat Dec 16 04:18:39 GMT 2023
PRIMARY
CAS
53005-05-3
Created by admin on Sat Dec 16 04:18:39 GMT 2023 , Edited by admin on Sat Dec 16 04:18:39 GMT 2023
NON-SPECIFIC STEREOCHEMISTRY
EPA CompTox
DTXSID20164976
Created by admin on Sat Dec 16 04:18:39 GMT 2023 , Edited by admin on Sat Dec 16 04:18:39 GMT 2023
PRIMARY
PUBCHEM
5281951
Created by admin on Sat Dec 16 04:18:39 GMT 2023 , Edited by admin on Sat Dec 16 04:18:39 GMT 2023
PRIMARY