U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Showing 1 - 10 of 16 results

Status:
US Approved Rx (2025)
First approved in 1994

Class (Stereo):
CHEMICAL (ABSOLUTE)



Tacrolimus, previously known as FK506, is the active ingredient in Prograf. Tacrolimus is a macrolide immunosuppressant produced by Streptomyces tsukubaensis. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506...
Status:
US Approved Rx (2016)
First approved in 1991

Class (Stereo):
CHEMICAL (ABSOLUTE)



Simvastatin is a HMG-CoA Reductase Inhibitor that is FDA approved for the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It reduces levels of "bad" cholesterol (low-de...
Status:
US Approved Rx (1988)
First approved in 1988

Class (Stereo):
CHEMICAL (UNKNOWN)



Ioversol is an organoiodine compound that used as a contrast medium. It features both a high iodine content, as well as several hydrophilic groups. It is indicated in adults for peripheral and coronary arteriography and left ventriculography, for exc...
Status:
US Approved Rx (1985)
First approved in 1985

Class (Stereo):
CHEMICAL (MIXED)



Iohexol is a nonionic, water-soluble radiographic contrast medium. Organic iodine compounds block x-rays as they pass through the body, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not co...
Status:
US Previously Marketed
First approved in 1997

Class (Stereo):
CHEMICAL (ABSOLUTE)



Cerivastatin (BAYCOL®) is a competitive inhibitor of HMG-CoA reductase, which is responsible for the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) to mevalonate, a precursor of sterols, including cholesterol. The inhibition of choles...
Status:
US Previously Marketed
First approved in 1995

Class (Stereo):
CHEMICAL (MIXED)

Conditions:

Ioxilan is a nonionic X-ray contrast agent approved by the United States Food and Drug Administration for X-ray imaging contrast enhancement. Ioxilan can be administered intravenously for excretory urography and contrast-enhanced computed tomography ...
Status:
US Previously Marketed
First approved in 1977

Class (Stereo):
CHEMICAL (ACHIRAL)



Probucol is used to lower levels of cholesterol (a fat-like substance) in the blood. Probucol is a drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. This may help prevent medical problems caus...
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (MIXED)

Conditions:

Iobitridol is a contrast medium used for intravenous urography, cerebral computed tomography, computed tomography of the whole body, digital subtraction angiography, arteriography, angiocardiography, venography, CT scan of the thorax. The drug is mar...
Status:
US Approved Rx (2025)
First approved in 1994

Class (Stereo):
CHEMICAL (ABSOLUTE)



Tacrolimus, previously known as FK506, is the active ingredient in Prograf. Tacrolimus is a macrolide immunosuppressant produced by Streptomyces tsukubaensis. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506...

Showing 1 - 10 of 16 results