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Details

Stereochemistry ABSOLUTE
Molecular Formula C44H69NO12.H2O
Molecular Weight 822.0334
Optical Activity ( - )
Defined Stereocenters 14 / 14
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of TACROLIMUS

SMILES

O.CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]2OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)OC

InChI

InChIKey=NWJQLQGQZSIBAF-MLAUYUEBSA-N
InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1

HIDE SMILES / InChI

Molecular Formula C44H69NO12
Molecular Weight 804.0182
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 14 / 14
E/Z Centers 1
Optical Activity UNSPECIFIED

Molecular Formula H2O
Molecular Weight 18.0153
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Tacrolimus, previously known as FK506, is the active ingredient in Prograf. Tacrolimus is a macrolide immunosuppressant produced by Streptomyces tsukubaensis. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription. Tacrolimus inhibits T-lymphocyte activation, although the exact mechanism of action is not known. Experimental evidence suggests that tacrolimus binds to an intracellular protein, FKBP-12. A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin inhibited. This effect may prevent the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines (such as interleukin-2, gamma interferon). The net result is the inhibition of T-lymphocyte activation (i.e., immunosuppression). Prograf is indicated for the prophylaxis of organ rejection in patients receiving allogeneic liver transplants, kidney transplants, heart transplants. It has also been used in a topical preparation in the treatment of severe atopic dermatitis.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
PROGRAF

Approved Use

Prograf is a calcineurin-inhibitor immunosuppressant indicated for: Prophylaxis of organ rejection in patients receiving allogeneic liver, kidney or heart transplants. Use concomitantly with adrenal corticosteroids; in kidney and heart transplant, use in conjunction with azathioprine or mycophenolate mofetil (MMF)

Launch Date

1994
Primary
Unknown

Approved Use

Unknown
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
6.2 ng/mL
4 mg 1 times / day multiple, oral
dose: 4 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TACROLIMUS blood
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
26 ng/mL
0.2 mg/kg 1 times / day multiple, oral
dose: 0.2 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TACROLIMUS blood
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
74 ng × h/mL
4 mg 1 times / day multiple, oral
dose: 4 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TACROLIMUS blood
Homo sapiens
population: HEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
372 ng × h/mL
0.2 mg/kg 1 times / day multiple, oral
dose: 0.2 mg/kg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
TACROLIMUS blood
Homo sapiens
population: UNHEALTHY
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
0.15 mg/kg 2 times / day steady, oral
Dose: 0.15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.15 mg/kg, 2 times / day
Sources:
unhealthy, 1.9 years (range: 3-15 years)
Health Status: unhealthy
Age Group: 1.9 years (range: 3-15 years)
Sex: M+F
Sources:
Disc. AE: Anemia, Edema lung...
AEs leading to
discontinuation/dose reduction:
Anemia
Edema lung
Allergic reaction
Abnormal liver function tests
Bilirubinemia
Lymphoma like reaction
Diarrhea
Intestinal obstruction
Sources:
5.2 mg 1 times / day multiple, oral
Highest studied dose
Dose: 5.2 mg, 1 times / day
Route: oral
Route: multiple
Dose: 5.2 mg, 1 times / day
Sources:
unhealthy, adult
8 mg single, oral
Highest studied dose
unhealthy, adult
0.1 mg/kg 2 times / day multiple, oral
Recommended
Dose: 0.1 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 0.1 mg/kg, 2 times / day
Sources:
unhealthy, adult
Other AEs: Infection...
0.02 mg/kg single, intravenous
Dose: 0.02 mg/kg
Route: intravenous
Route: single
Dose: 0.02 mg/kg
Sources:
unhealthy, adult
0.03 % 1 times / day multiple, topical
Dose: 0.03 %, 1 times / day
Route: topical
Route: multiple
Dose: 0.03 %, 1 times / day
Sources:
unhealthy
Health Status: unhealthy
Sources:
AEs

AEs

AESignificanceDosePopulation
Abnormal liver function tests Disc. AE
0.15 mg/kg 2 times / day steady, oral
Dose: 0.15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.15 mg/kg, 2 times / day
Sources:
unhealthy, 1.9 years (range: 3-15 years)
Health Status: unhealthy
Age Group: 1.9 years (range: 3-15 years)
Sex: M+F
Sources:
Allergic reaction Disc. AE
0.15 mg/kg 2 times / day steady, oral
Dose: 0.15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.15 mg/kg, 2 times / day
Sources:
unhealthy, 1.9 years (range: 3-15 years)
Health Status: unhealthy
Age Group: 1.9 years (range: 3-15 years)
Sex: M+F
Sources:
Anemia Disc. AE
0.15 mg/kg 2 times / day steady, oral
Dose: 0.15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.15 mg/kg, 2 times / day
Sources:
unhealthy, 1.9 years (range: 3-15 years)
Health Status: unhealthy
Age Group: 1.9 years (range: 3-15 years)
Sex: M+F
Sources:
Bilirubinemia Disc. AE
0.15 mg/kg 2 times / day steady, oral
Dose: 0.15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.15 mg/kg, 2 times / day
Sources:
unhealthy, 1.9 years (range: 3-15 years)
Health Status: unhealthy
Age Group: 1.9 years (range: 3-15 years)
Sex: M+F
Sources:
Diarrhea Disc. AE
0.15 mg/kg 2 times / day steady, oral
Dose: 0.15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.15 mg/kg, 2 times / day
Sources:
unhealthy, 1.9 years (range: 3-15 years)
Health Status: unhealthy
Age Group: 1.9 years (range: 3-15 years)
Sex: M+F
Sources:
Edema lung Disc. AE
0.15 mg/kg 2 times / day steady, oral
Dose: 0.15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.15 mg/kg, 2 times / day
Sources:
unhealthy, 1.9 years (range: 3-15 years)
Health Status: unhealthy
Age Group: 1.9 years (range: 3-15 years)
Sex: M+F
Sources:
Intestinal obstruction Disc. AE
0.15 mg/kg 2 times / day steady, oral
Dose: 0.15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.15 mg/kg, 2 times / day
Sources:
unhealthy, 1.9 years (range: 3-15 years)
Health Status: unhealthy
Age Group: 1.9 years (range: 3-15 years)
Sex: M+F
Sources:
Lymphoma like reaction Disc. AE
0.15 mg/kg 2 times / day steady, oral
Dose: 0.15 mg/kg, 2 times / day
Route: oral
Route: steady
Dose: 0.15 mg/kg, 2 times / day
Sources:
unhealthy, 1.9 years (range: 3-15 years)
Health Status: unhealthy
Age Group: 1.9 years (range: 3-15 years)
Sex: M+F
Sources:
Infection serious
0.1 mg/kg 2 times / day multiple, oral
Recommended
Dose: 0.1 mg/kg, 2 times / day
Route: oral
Route: multiple
Dose: 0.1 mg/kg, 2 times / day
Sources:
unhealthy, adult
OverviewDrug as perpetrator​Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
no
no
no
no
no
no
no
yes
yes
yes
yes (co-administration study)
Comment: Tacrolimus was metabolized by the cytochrome P450 (CYP) 3A subfamily. Metabolic drug-drug interaction studies were conducted to provide information regarding the optimal usage of tacrolimus, and its metabolism was inhibited by known CYP3A inhibitors such as ketoconazole, cyclosporine A, and nifedipine. Recent reports on clinical pharmacokinetics indicate that dose levels of tacrolimus need to be adjusted in transplant patients with CYP3A5 polymorphism.
Page: -
yes
yes (pharmacogenomic study)
Comment: Tacrolimus was metabolized by the cytochrome P450 (CYP) 3A subfamily. Metabolic drug-drug interaction studies were conducted to provide information regarding the optimal usage of tacrolimus, and its metabolism was inhibited by known CYP3A inhibitors such as ketoconazole, cyclosporine A, and nifedipine. Recent reports on clinical pharmacokinetics indicate that dose levels of tacrolimus need to be adjusted in transplant patients with CYP3A5 polymorphism.
Page: -
PubMed

PubMed

TitleDatePubMed
Neurotoxicity after orthotopic liver transplantation in cyclosporin A- and FK 506-treated patients.
1994
Renal complications and development of hypertension in the European study of FK 506 and cyclosporin in primary liver transplant recipients.
1994
Tacrolimus toxicity in rhesus monkey: model for clinical side effects.
1999 Dec
Rapamycin inhibits didemnin B-induced apoptosis in human HL-60 cells: evidence for the possible involvement of FK506-binding protein 25.
1999 Jun
Calcineurin and vacuolar-type H+-ATPase modulate macrophage effector functions.
1999 May 25
Leg bone pain syndrome in a kidney transplant patient treated with tacrolimus (FK506).
1999 Oct
Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB.
1999 Sep
Tacrolimus in acute renal failure: does L-arginine-infusion prevent changes in renal hemodynamics?
2000
Arteriolopathy in non-episode biopsies of renal transplant allograft.
2000
Co-administration of furosemide augments tacrolimus-induced impairment in kidney function in rats.
2000
Treatment of tacrolimus-related adverse effects by conversion to cyclosporine in liver transplant recipients.
2000
Reversible tacrolimus-induced neurotoxicity isolated to the brain stem.
2000 Aug
Suppressive effects of cyclosporin A and FK-506 on superoxide generation in human polymorphonuclear leukocytes primed by tumor necrosis factor alpha.
2000 Dec
Sirolimus in pediatric gastrointestinal transplantation: the use of sirolimus for pediatric transplant patients with tacrolimus-related cardiomyopathy.
2000 Feb
Conversion to neoral for neurotoxicity after primary adult liver transplantation under tacrolimus.
2000 Jan 15
Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells.
2000 Jul 15
Effect of aminophylline on urine flow in children with tacrolimus-induced renal insufficiency.
2000 Jun
Cortical laminar necrosis caused by immunosuppressive therapy and chemotherapy.
2000 Mar
FK506 inhibition of histamine release and cytokine production by mast cells and basophils.
2000 Mar
Immunosuppressive drugs: the first 50 years and a glance forward.
2000 May
Tacrolimus has less fibrogenic potential than cyclosporin A in a model of renal ischaemia-reperfusion injury.
2000 Nov
Fatal cerebral hemorrhage associated with cyclosporin-A/FK506-related encephalopathy after allogeneic bone marrow transplantation.
2000 Oct
Cyclosporine and tacrolimus-associated thrombotic microangiopathy.
2000 Oct
Conversion to rapamycin immunosuppression in renal transplant recipients: report of an initial experience.
2000 Oct 27
Delayed transient neurologic toxicity due to tacrolimus: CT and MRI.
2000 Sep
Tacrolimus-associated mutism after orthotopic liver transplantation.
2000 Sep 27
[Acute peripheral demyelinating polyneuropathy and acute renal failure after administration of FK506].
2001
Calcineurin-inhibitor related nephrotoxicity- reversibility in paediatric liver transplant recipients.
2001 Aug 27
End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment.
2001 Dec 27
Sirolimus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 production.
2001 Feb
Mycophenolate mofetil monotherapy in liver transplantation.
2001 Feb 24
Targeting keratinocyte apoptosis in the treatment of atopic dermatitis and allergic contact dermatitis.
2001 Nov
Posttransplantation diabetes mellitus in FK-506-treated renal transplant recipients: analysis of incidence and risk factors.
2001 Nov 27
Sirolimus and mycophenolate mofetil for calcineurin-free immunosuppression in renal transplant recipients.
2001 Oct
Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus.
2001 Oct
Expression of TGF-beta and fibrogenic genes in transplant recipients with tacrolimus and cyclosporine nephrotoxicity.
2002 Dec
Calcineurin inhibitors, cyclosporin A and tacrolimus inhibit expression of inducible nitric oxide synthase in colon epithelial and macrophage cell lines.
2002 Jul 19
FK 506-induced fulminant leukoencephalopathy after kidney transplantation: case report.
2002 Jun
Downregulation of both interleukin-12 and interleukin-2 in heart allografts by pretransplant host treatment with granulocyte colony-stimulating factor and tacrolimus.
2002 May 7
Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril.
2002 Oct
Long-term comparison of tacrolimus- and cyclosporine-induced nephrotoxicity in pediatric heart-transplant recipients.
2002 Sep
Neuropsychologic side-effects of tacrolimus in pediatric renal transplantation.
2003 Apr
Speech disorder related to tacrolimus-induced pontine myelinolysis after orthotopic liver transplantation.
2003 Aug
Treatment of human T cells with bisperoxovanadium phosphotyrosyl phosphatase inhibitors leads to activation of cyclooxygenase-2 gene.
2003 Feb 28
Steroid-free immunosuppression during and after liver transplantation--a 3-yr follow-up report.
2003 Jun
Microangiopathic haemolytic anaemia and thrombocytopenia following lung volume reduction surgery in a single lung transplant recipient on maintenance tacrolimus (FK506) therapy.
2003 Jun
Tacrolimus-induced hemolytic uremic syndrome case presentation in a lung transplant recipient.
2003 Mar
The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response.
2003 Mar
Enhanced interleukin-4 production in CD4+ T cells and elevated immunoglobulin E levels in antigen-primed mice by bisphenol A and nonylphenol, endocrine disruptors: involvement of nuclear factor-AT and Ca2+.
2003 May
MR imaging with quantitative diffusion mapping of tacrolimus-induced neurotoxicity in organ transplant patients.
2003 May
Patents

Sample Use Guides

Dosage in Adult Kidney, Liver, or Heart Transplant Patients: Adult kidney transplant patients (Oral Dosage: daily doses should be administered as two divided doses, every 12 hours): in combination with azathioprine: 0.2 mg/kg/day; in combination with MMF/IL-2 receptor antagonist: 0.1 mg/kg/day. Adult liver transplant patients: 0.10-0.15 mg/kg/day. Adult heart transplant patients: 0.075 mg/kg/day. Prograf (TACROLIMUS) injection should be used only as a continuous IV infusion and when the patient cannot tolerate oral administration of Prograf capsules. Prograf injection should be discontinued as soon as the patient can tolerate oral administration of Prograf capsules, usually within 2-3 days. In a patient receiving an IV infusion, the first dose of oral therapy should be given 8-12 hours after discontinuing the IV infusion. The recommended starting dose of Prograf injection is 0.03-0.05 mg/kg/day in kidney and liver transplant and 0.01 mg/kg/day in heart transplant given as a continuous IV infusion. Adult patients should receive doses at the lower end of the dosing range. Concomitant adrenal corticosteroid therapy is recommended early post-transplantation. Dosage in Pediatric Liver Transplant Patients: (Oral Dosage): Pediatric liver transplant patients 0.15-0.20 mg/kg/day (daily doses should be administered as two divided doses, every 12 hours)
Route of Administration: Other
Tacrolimus at concentration of 0.06 μmol/L could promote collagen induced platelet aggregation, inhibit thrombin induced platelet aggregation, have no effect on ristocetin and vWF induced platelet aggregation function. Tacrolimus at concentration of 120 μmol/L and 240 μmol/L could reduce the platelet mitochondrial membrane potential and induce the expression of apoptosis protein caspase-3. In vitro experimental results showed that high concentration of tacrolimus could lead to platelet apoptosis. But the current therapeutic dose of tacrolimus at 0.06 μmol/L (which is equivalent to 50 ng/ml blood concentration) could have different effects on platelet aggregation function according to different stimulating agents.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:08:23 GMT 2025
Edited
by admin
on Mon Mar 31 18:08:23 GMT 2025
Record UNII
WM0HAQ4WNM
Record Status Validated (UNII)
Record Version
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Name Type Language
TACROLIMUS MONOHYDRATE
MI   WHO-DD  
Preferred Name English
TACROLIMUS
EMA EPAR   ORANGE BOOK   USAN   USP   USP-RS   VANDF  
USAN  
Official Name English
FK 506
Code English
TACROLIMUS [ORANGE BOOK]
Common Name English
TACROLIMUS [USP-RS]
Common Name English
TACROLIMUS HYDRATE [JAN]
Common Name English
NSC-758659
Code English
MODIGRAF
Brand Name English
TACROLIMUS [EMA EPAR]
Common Name English
PROTOPIC
Brand Name English
FK-506
Code English
FK506
Code English
TACROLIMUS HYDRATE
JAN  
Common Name English
TACROLIMUS [VANDF]
Common Name English
TACROLIMUS MONOHYDRATE [MI]
Common Name English
TACROLIMUS [USAN]
Common Name English
PROGRAF
Brand Name English
ADVAGRAF
Brand Name English
Tacrolimus monohydrate [WHO-DD]
Common Name English
15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-t
Systematic Name English
TACROLIMUS MONOHYDRATE [EP MONOGRAPH]
Common Name English
ENVARSUS XR
Brand Name English
(?)-(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Allyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-
Systematic Name English
FR-900506
Code English
FR900506
Code English
TACROLIMUS [USP MONOGRAPH]
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 472815
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
FDA ORPHAN DRUG 743220
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
FDA ORPHAN DRUG 534516
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
WHO-VATC QD11AH01
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
FDA ORPHAN DRUG 407113
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
EMA ASSESSMENT REPORTS ADVAGRAF (AUTHORIZED: GRAFT REJECTION)
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
FDA ORPHAN DRUG 314310
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
LIVERTOX NBK548545
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
WHO-ATC L04AD02
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
NCI_THESAURUS C2201
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
EMA ASSESSMENT REPORTS ENVARSUS (AUTHORIZED: GRAFT REJECTION)
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
EMA ASSESSMENT REPORTS MODIGRAF (AUTHORIZED: GRAFT REJECTION)
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
FDA ORPHAN DRUG 468214
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
FDA ORPHAN DRUG 849321
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
NDF-RT N0000175457
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
FDA ORPHAN DRUG 701319
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
FDA ORPHAN DRUG 753620
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
FDA ORPHAN DRUG 203305
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
EU-Orphan Drug EU/3/03/185
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
WHO-ATC D11AH01
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
EMA ASSESSMENT REPORTS PROTOPIC (AUTHORIZED: PSORIASIS)
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
FDA ORPHAN DRUG 111398
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
NCI_THESAURUS C146638
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
WHO-VATC QL04AD02
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
EMA ASSESSMENT REPORTS PROTOPY (AUTHORIZED: DERMATATIS, ATOPIC)
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
Code System Code Type Description
NSC
758659
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
ChEMBL
CHEMBL269732
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
EVMPD
SUB23141
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
NCI_THESAURUS
C1311
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
DRUG CENTRAL
2552
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
RXCUI
484288
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
CHEBI
61049
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
WIKIPEDIA
TACROLIMUS
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
CAS
109581-93-3
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
IUPHAR
6784
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
PUBCHEM
5282315
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
RXCUI
42316
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
ALTERNATIVE
SMS_ID
100000087996
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
EVMPD
SUB25193
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
DRUG BANK
DB00864
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
MESH
D016559
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
DAILYMED
WM0HAQ4WNM
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY
LACTMED
Tacrolimus
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
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MERCK INDEX
m10425
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID001350197
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
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FDA UNII
WM0HAQ4WNM
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
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CHEBI
61057
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
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RS_ITEM_NUM
1642802
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
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USAN
EE-43
Created by admin on Mon Mar 31 18:08:23 GMT 2025 , Edited by admin on Mon Mar 31 18:08:23 GMT 2025
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ACTIVE MOIETY