IOBITRIDOL

Possibly Marketed Outside US

Details

Stereochemistry	MIXED
Molecular Formula	C20H28I3N3O9
Molecular Weight	835.1644
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CN(CC(O)CO)C(=O)C1=C(I)C(C(=O)N(C)CC(O)CO)=C(I)C(NC(=O)C(CO)CO)=C1I

InChI

InChIKey=YLPBXIKWXNRACS-UHFFFAOYSA-N

InChI=1S/C20H28I3N3O9/c1-25(3-10(31)7-29)19(34)12-14(21)13(20(35)26(2)4-11(32)8-30)16(23)17(15(12)22)24-18(33)9(5-27)6-28/h9-11,27-32H,3-8H2,1-2H3,(H,24,33)

HIDE SMILES / InChI

Molecular Formula	C20H28I3N3O9
Molecular Weight	835.1644
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description

Iobitridol is a contrast medium used for intravenous urography, cerebral computed tomography, computed tomography of the whole body, digital subtraction angiography, arteriography, angiocardiography, venography, CT scan of the thorax. The drug is marketed under the name Xenetix.

CNS Activity

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Contrast agent 13	Diagnostic		Approved 8,583	XENETIX

F_unbound

F_unbound

Value	Dose	Co-administered	Analyte	Population
97.9%			IOBITRIDOL unknown	Homo sapiens

Doses

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Dose	Population	Adverse events
102.5 mL single, intravascular Recommended	unknown, ADULT	Disc. AE: Cardiac failure...

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AEs

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AE	Significance	Dose	Population
Cardiac failure	grade 5, 0.002% Disc. AE	102.5 mL single, intravascular Recommended	unknown, ADULT

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PubMed

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Title	Date	PubMed
Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity.	2004 Feb	14972420
Nephrotoxicity of low-osmolality versus iso-osmolality contrast agents: impact of N-acetylcysteine.	2005 Nov	16221226
Nephrotoxicity of low-osmolar and iso-osmolar contrast media.	2006 Mar	16528264
Contrast-induced acute kidney injury in patients with renal dysfunction undergoing a coronary procedure and receiving non-ionic low-osmolar versus iso-osmolar contrast media.	2010 Jan	19996728

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Patents

Sample Use Guides

In Vivo Use Guide

1 ml/kg of Xenetix350 given as intravenous infusion (Intravenous urography, cerebral CT scan), 1,8 ml/kg (CT scan of the whole body), 2,2-3,6 ml/kg (arteriography), 1,9-4,6 ml/kg (angiocardiography).

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical
Record UNII	182ECH14UH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IOBITRIDOL [JAN]

Preferred Name

English

IOBITRIDOL

Official Name

English

1,3-BENZENEDICARBOXAMIDE, N1,N3-BIS(2,3-DIHYDROXYPROPYL)-5-((3-HYDROXY-2-(HYDROXYMETHYL)-1-OXOPROPYL)AMINO)-2,4,6-TRIIODO-N1,N3-DIMETHYL-

Systematic Name

English

N,N'-BIS(2,3-DIHYDROXYPROPYL)-5-(2-(HYDROXYMETHYL)HYDRACRYLAMIDO)-2,4,6-TRIIODO-N,N'-DIMETHYLISOPHTHALAMIDE

Systematic Name

English

iobitridol [INN]

Common Name

English

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Classification Tree

Code System

Code

Watersoluble, nephrotropic, low osmolar X-ray contrast media

WHO-ATC

V08AB11

Contrast Agent

NCI_THESAURUS

C28500

Watersoluble, nephrotropic, low osmolar X-ray contrast media

WHO-VATC

QV08AB11

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Code System

Code

Type

Description

WIKIPEDIA

IOBITRIDOL

PRIMARY

INN

7040

PRIMARY

PUBCHEM

65985

PRIMARY

EPA CompTox

DTXSID90869865

PRIMARY

DRUG BANK

DB12407

PRIMARY

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Related Record

Type

Details


					182ECH14UH

IOBITRIDOL

ACTIVE MOIETY

Amount:

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SMILES

InChI

CNS Activity

Approval Year

Conditions

Funbound

Doses

AEs

PubMed

Patents

Sample Use Guides

F_unbound