IOBITRIDOL

Possibly Marketed Outside US

Details

Stereochemistry	MIXED
Molecular Formula	C20H28I3N3O9
Molecular Weight	835.1644
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(CC(O)CO)C(=O)C1=C(I)C(C(=O)N(C)CC(O)CO)=C(I)C(NC(=O)C(CO)CO)=C1I

InChI

InChIKey=YLPBXIKWXNRACS-UHFFFAOYSA-N

InChI=1S/C20H28I3N3O9/c1-25(3-10(31)7-29)19(34)12-14(21)13(20(35)26(2)4-11(32)8-30)16(23)17(15(12)22)24-18(33)9(5-27)6-28/h9-11,27-32H,3-8H2,1-2H3,(H,24,33)

HIDE SMILES / InChI

Molecular Formula	C20H28I3N3O9
Molecular Weight	835.1644
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.aemps.gob.es/cima/pdfs/es/ft/61384/61384_ft.pdf

Iobitridol is a contrast medium used for intravenous urography, cerebral computed tomography, computed tomography of the whole body, digital subtraction angiography, arteriography, angiocardiography, venography, CT scan of the thorax. The drug is marketed under the name Xenetix.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Contrast agent 13 Sources: https://www.aemps.gob.es/cima/pdfs/es/ft/61384/61384_ft.pdf	Diagnostic		Approved 8583	XENETIX Approved Use Intravenous urography, cerebral computed tomography, computed tomography of the whole body, digital subtraction angiography, arteriography, angiocardiography, venography, CT scan of the thorax. Launch Date 1993

F_unbound

Value	Dose	Co-administered	Analyte	Population
97.9% REVIEW https://pubmed.ncbi.nlm.nih.gov/23341290/			IOBITRIDOL unknown	Homo sapiens

Doses

Dose	Population	Adverse events
102.5 mL single, intravascular Recommended Dose: 102.5 mL Route: intravascular Route: single Dose: 102.5 mL Sources: https://pubmed.ncbi.nlm.nih.gov/12942302/	unknown, ADULT Health Status: unknown Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/12942302/	Disc. AE: Cardiac failure... AEs leading to discontinuation/dose reduction: Cardiac failure (grade 5, 0.002%) Sources: https://pubmed.ncbi.nlm.nih.gov/12942302/

AEs

AE	Significance	Dose	Population
Cardiac failure	grade 5, 0.002% Disc. AE	102.5 mL single, intravascular Recommended Dose: 102.5 mL Route: intravascular Route: single Dose: 102.5 mL Sources: https://pubmed.ncbi.nlm.nih.gov/12942302/	unknown, ADULT Health Status: unknown Age Group: ADULT Sex: M+F Food Status: UNKNOWN Sources: https://pubmed.ncbi.nlm.nih.gov/12942302/

PubMed

Title	Date	PubMed
Contrast-induced acute kidney injury in patients with renal dysfunction undergoing a coronary procedure and receiving non-ionic low-osmolar versus iso-osmolar contrast media.	2010-01	19996728
Nephrotoxicity of low-osmolar and iso-osmolar contrast media.	2006-03	16528264
Nephrotoxicity of low-osmolality versus iso-osmolality contrast agents: impact of N-acetylcysteine.	2005-11	16221226
Standard vs double dose of N-acetylcysteine to prevent contrast agent associated nephrotoxicity.	2004-02	14972420
A comparison of the efficacy and safety of ioxaglate and iobitridol in renal angioplasty.	2000-05-05	10795832

Patents

Sample Use Guides

In Vivo Use Guide

1 ml/kg of Xenetix350 given as intravenous infusion (Intravenous urography, cerebral CT scan), 1,8 ml/kg (CT scan of the whole body), 2,2-3,6 ml/kg (arteriography), 1,9-4,6 ml/kg (angiocardiography).

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:05:01 GMT 2025` Edited by `admin` on `Mon Mar 31 18:05:01 GMT 2025`
Record UNII	182ECH14UH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

IOBITRIDOL [JAN]

Preferred Name

English

IOBITRIDOL

Official Name

English

1,3-BENZENEDICARBOXAMIDE, N1,N3-BIS(2,3-DIHYDROXYPROPYL)-5-((3-HYDROXY-2-(HYDROXYMETHYL)-1-OXOPROPYL)AMINO)-2,4,6-TRIIODO-N1,N3-DIMETHYL-

Systematic Name

English

N,N'-BIS(2,3-DIHYDROXYPROPYL)-5-(2-(HYDROXYMETHYL)HYDRACRYLAMIDO)-2,4,6-TRIIODO-N,N'-DIMETHYLISOPHTHALAMIDE

Systematic Name

English

iobitridol [INN]

Common Name

English

N,N'-BIS(2,3-DIHYDROXYPROPYL)-5-((3-HYDROXY-2-(HYDROXYMETHYL)-1-OXOPROPYL)AMINO)-2,4,6-TRIIODO-N,N'-DIMETHYL-1,3-BENZENEDICARBOXAMIDE

Systematic Name

English

IOBITRIDOL [MI]

Common Name

English

IOBITRIDOL [MART.]

Common Name

English

5-(3-HYDROXY-2-(HYDROXYMETHYL)-PROPIONAMIDO)-N,N'-DIMETHYL-N,N'-BIS-(2,3-DIHYDROXYPROPYL)-2,4,6-TRIIODOISOPHTHALAMIDE

Systematic Name

English

Iobitridol [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-ATC

V08AB11