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Status:
Possibly Marketed Outside US
Source:
Amantocillin by Onbio Inc.
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
Amantocillin, 6-aminopenicillanic acid derivative, is an old highly active penicillinase-resistant broad-spectrum antibiotic.
Status:
Possibly Marketed Outside US
Source:
Bacmecillinam by ZYF Pharm Chemical
Source URL:
Class (Stereo):
CHEMICAL (EPIMERIC)
Bacmecillinam is the orally active 1’-ethoxycarbonyloxyethyl ester of macillinam. It is rapidly absorbed and hydrolyzed, liberating the antibacterially active drug mecillinam. Protective effects of bacmecillinam was tested in experimental mouse intraperitoneal infection model. Drug demonstrated the potent protective effects against E. coli GN 2411-5, E. coli 2848, K. pneumoniae 8045, E. cloacae F-1510 and P. mirabilis F-783 infection.
Status:
Possibly Marketed Outside US
Source:
Gitaloxin by Shanghai Lansheng Corporation
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Gitaloxin or 16-formylgiloxine is a cardiotonic glycoside extracted from Digitalis purpurea. It acts as a Na, K-ATPase. Gitaloxin has been investigated in the treatment of cardiac insufficiency.
Status:
Possibly Marketed Outside US
Source:
Ansoxetine by ZYF Pharm Chemical
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Ansoxetine is an antidepressant which was never marketed.
Status:
Possibly Marketed Outside US
Source:
Valbil by Rohm Pharma [W. Germany]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
FEBUPROL is a choleretic drug.
Status:
Possibly Marketed Outside US
Source:
Apovincamine by GC Promochem
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Apovincamine is a vinca alkaloid derivative, which is structurally related to vinpocetine. Apovincamine is produced when vincamine, an alkaloid constituent of Vinca species, is heated to 220°C. Apovincamine suppresses melanogenesis in B16 mouse melanoma cells.
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Bisoxatin (Laxonalin, Wylaxine) acetate is a stimulant laxative that has been used in the treatment of constipation. The drug showed good effects to habitual constipation and dolichocolon but was not sufficient acting in megacolon. It seems that the drug is effective to constipation due to functional disorders but the effect is not sufficient to constipation caused chiefly by organic colonic changes. No side effect was observed even in long term administration.
Status:
Possibly Marketed Outside US
Source:
Aptazapine maleate by ZYF Pharm Chemical
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Aptazapine is a “non-classic” tetracyclic antidepressant drug. Compound bears a structural resemblance to mianserin. Aptazapine possesses a high degree of potency and selectivity for central alpha-2, as opposed to alpha-1, adrenoceptors. Aptazapine failed to inhibit in vitro uptake of norepinephrine or serotonin to an appreciable extent. However, it exhibited a moderate ability to compete for 5-HT2 receptor binding in calf frontal cortex, as measured by displacement of 3H-spiroperidol. Another property apparently shared with other antidepressants is the ability of aptazapine to inhibit histamine-activated adenyl cyclase. As centrally acting alpha-2 adrenoceptor antagonists, aptazapine significantly suppressed cataplexy, a major symptom of narcolepsy, in Doberman pinschers.
Status:
Possibly Marketed Outside US
Source:
Butinazocine by ZYF Pharm Chemical
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Butinazocine is an opioid analgesic of the benzomorphan family which was never marketed.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Protiofate (Atrimycon), a molecule derived from thiophene, is a topical fungicide. It was used for the treatment of trichomonal and fungal infections.
