U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ABSOLUTE
Molecular Formula C21H24N2O2
Molecular Weight 336.4275
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of APOVINCAMINE

SMILES

CC[C@@]12CCCN3CCC4=C([C@H]13)N(C5=C4C=CC=C5)C(=C2)C(=O)OC

InChI

InChIKey=OZDNDGXASTWERN-CTNGQTDRSA-N
InChI=1S/C21H24N2O2/c1-3-21-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(18(15)19(21)22)17(13-21)20(24)25-2/h4-5,7-8,13,19H,3,6,9-12H2,1-2H3/t19-,21+/m1/s1

HIDE SMILES / InChI

Description

Apovincamine is a vinca alkaloid derivative, which is structurally related to vinpocetine. Apovincamine is produced when vincamine, an alkaloid constituent of Vinca species, is heated to 220°C. Apovincamine suppresses melanogenesis in B16 mouse melanoma cells.

Approval Year

Unknown
149,124

Targets

Primary TargetPharmacologyConditionPotency
Bacteria
7
Inhibitor
8,504
Melanogenesis
5
Inhibitor
8,504

Patents

20090062529
4
20100226943
186
ACTIVE MOIETY
Structure of APOVINCAMINE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966