U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 161 - 170 of 511 results

Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Narceine methyl ester and narceine are potent alkaloids which were isolated from Corydalis longipes were found effective in vitro at very low concentration, i.e., 100~500 ppm against spore germination of some test plant pathogenic fungi (Alternaria solani, A. tagetica, Cercospora abelmoschi, Curvularia maculans, Erysiphe cichoracearum, E. pisi, Fusarium udum, Helminthosporium oryzae, H. penniseti, Ustilago cynodontis). George Bell Frankforter was the first person to isolate narceine (in 1893) during his Ph.D. research for August Hofmann at the University of Berlin. Narceine has a weak morphine-like action, but is not much used in medicine. It may be administered in a pill, as a mild hypnotic and to allay cough; it is less depressant than morphine and does not constipate. Ethylnarceine is a narcotic, analgesic, and antitussive.
6-Methoxy-2-naphthalenecarboxaldehyde is a substrate of aldehyde dehydrogenase enzymes (class I, class II and class III). It was examined as indicator of the aldehyde dehydrogenase (ALDH) activity in human tissue homogenates and accessible body fluids from patients with viral and toxic liver injuries, and tumors. As intermediate, it was used in organic synthesis of enantiomerically enriched R- and S-6-MONCH- (OH)CN and fluorescent substrates for inhibition studies relating to hypertension and vascular inflammation.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Conditions:

Estradiol-glucoside, also known as E2-3beta-glucoside, is a novel conjugated estrogen synthesized by attaching a glucose molecule to the 3beta position of estradiol. This glucoside derivative is a water-soluble estrogen that is easily absorbed from the gastrointestinal tract and achieves favorable systemic estrogen levels. The results of a randomized, double-blinded controlled pilot study have revealed, that estradiol-glucoside reduced serum gonadotropin levels in the premenopausal range and could be effective at reducing postmenopausal symptoms. As a conclusion, was made the assumption, that estradiol-glucoside can serve as a hormone replacement therapy.
Status:
Other

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

Magnesium Pyrrolidone Carboxylate is soluble Magnesium salt, that can be used as spasmolytics in cervix dystocia during labor
SDZ-WAG-994 is a potent and selective A1 receptor agonist, discovered by Sandoz. SDZ-WAG-994 was able to induce a dose-related and sustained fall in blood pressure and heart rate in spontaneously hypertensive rats. The compound was investigated in patients with heart failure symptoms and moderate left ventricular systolic dysfunction, where it produced no effect. In patients with patients with permanent atrial fibrillation, SDZ-WAG-994 was able to limit the increase in mean heart rate during exercise. The compound was also tested for treatment of postoperative dental pain, but for all efficacy measures, SDZ-WAG-994 was not significantly different from placebo.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:


Amphotericin B methyl ester (also known as metamphocin), a more soluble and less toxic formulation of amphotericin B, is a new antifungal polyene antibiotic, which was studied to treat ocular mycoses and was proposed to treat Candida endophthalmitis. The suggested mechanism of its action includes the binding of this drug with the ergosterol-containing membranes.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


There has been little interest in the biological and pharmacological application of triamcinolone acetonide hemisuccinate. Although, at one time this compound was used as a topical steroid to treat the ocular inflammation.
Status:
Other

Class (Stereo):
CHEMICAL (ABSOLUTE)


ALLOPREGNANE-3β,17α,21-TRIOL-20-ONE is a bioactive progestin proposed for the treatment of ischemic damage, such as damage due to stroke or myocardial infarction and, as the neuroactive steroid, for the treatment of epilepsy or status epilepticus.
Thiosalicylic acid is an analgesic and anti-inflammatory agent. It is used (in form of sodium salt) to relieve symptoms of acute gout, painful musculoskeletal conditions, osteoarthritis and rheumatic fever. The drug exerts its action by inhibiting prostaglandin synthesis. Thiosalicylic acid usage is associated with the risk of contact dermatitis.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

SCH-28080 is an inhibitor of H+, K+-ATPase. Administration of SCH-28080 led to significant reduction in the volume, acid output and peptic activity of gastric secretions in a clinical trial.

Showing 161 - 170 of 511 results