Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H6O2S |
| Molecular Weight | 154.186 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=C(S)C=CC=C1
InChI
InChIKey=NBOMNTLFRHMDEZ-UHFFFAOYSA-N
InChI=1S/C7H6O2S/c8-7(9)5-3-1-2-4-6(5)10/h1-4,10H,(H,8,9)
Thiosalicylic acid is an analgesic and anti-inflammatory agent. It is used (in form of sodium salt) to relieve symptoms of acute gout, painful musculoskeletal conditions, osteoarthritis and rheumatic fever. The drug exerts its action by inhibiting prostaglandin synthesis. Thiosalicylic acid usage is associated with the risk of contact dermatitis.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | REXOLATE Approved UseTo relieve symptoms of acute gout, to relieve pain from musculoskeletal conditions, to relieve symptoms of osteoarthritis, to treat rheumatic fever. |
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| Palliative | REXOLATE Approved UseTo relieve symptoms of acute gout, to relieve pain from musculoskeletal conditions, to relieve symptoms of osteoarthritis, to treat rheumatic fever. |
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| Palliative | REXOLATE Approved UseTo relieve symptoms of acute gout, to relieve pain from musculoskeletal conditions, to relieve symptoms of osteoarthritis, to treat rheumatic fever. |
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| Primary | REXOLATE Approved UseTo relieve symptoms of acute gout, to relieve pain from musculoskeletal conditions, to relieve symptoms of osteoarthritis, to treat rheumatic fever. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Simultaneous determination of reduced and oxidized glutathione in peripheral blood mononuclear cells by liquid chromatography-electrospray mass spectrometry. | 2001 Jun 5 |
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| Cytotoxicity of Triorganophosphinegold(I) n-Mercaptobenzoates, n = 2, 3 and 4. | 2002 |
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| Effect of taxol and okadaic acid on microtubule dynamics in thimerosal-arrested primary mouse oocytes: a confocal study. | 2003 Sep |
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| One-pot synthesis of benzo[e]1,4-oxathiepin-5-ones under solvent-free condition via self-promoted thiolysis of 1,2-epoxides. | 2004 Dec 10 |
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| Self-assembly of dialkyltin moieties and mercaptobenzoic acid into macrocyclic complexes with hydrophobic "pseudo-cage" or double-cavity structures: supramolecular infrastructures involving intermolecular C-H...S weak hydrogen bonds and pi-pi interactions. | 2005 Dec 23 |
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| Chelating sorbents based on silica gel and their application in atomic spectrometry. | 2005 Mar |
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| Determination of mercury complexation in coastal and estuarine waters using competitive ligand exchange method. | 2005 Sep 1 |
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| Field amplified sample injection-capillary electrophoresis-tandem mass spectrometry for the analysis of acrylamide in foodstuffs. | 2007 Aug 3 |
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| Zinc ions cause the thimerosal-induced signal of fluorescent calcium probes in lymphocytes. | 2009 Feb |
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| Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in children. | 2009 Oct 27 |
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| Synthesis and characterization of thiosalicylic acid stabilized gold nanoparticles. | 2009 Sep 15 |
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| 14-(1,3-Benzodioxol-5-yl)-7,14-dihydro-dibenzo[a,j]acridine. | 2010 Nov 6 |
Sample Use Guides
Acute gout: initial dose is 100 mg every 3 to 4 hours for 2 days, then 100 mg daily. Painful musculoskeletal conditions: 50 to 100 mg daily or every other day. Osteoarthritis: 10 mg 3 times/week for several weeks then once a week, usually up to a total dosage of 2.5 g. Rheumatic fever: initial dose is 100 to 150 mg every 4 to 8 hours for 3 days, then 100 mg two times daily.
Route of Administration:
Other
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EPA PESTICIDE CODE |
78903
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NCI_THESAURUS |
C257
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660640
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THIOSALICYLIC ACID
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C441201
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2184
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5443
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322165
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DTXSID4049032
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59124
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91099
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CIP6LXN5XW
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59127
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m10783
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147-93-3
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2739
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DB14026
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C87327
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100000183747
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205-704-3
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
