Estradiol-glucoside, also known as E2-3beta-glucoside, is a novel conjugated estrogen synthesized by attaching a glucose molecule to the 3beta position of estradiol. This glucoside derivative is a water-soluble estrogen that is easily absorbed from the gastrointestinal tract and achieves favorable systemic estrogen levels. The results of a randomized, double-blinded controlled pilot study have revealed, that estradiol-glucoside reduced serum gonadotropin levels in the premenopausal range and could be effective at reducing postmenopausal symptoms. As a conclusion, was made the assumption, that estradiol-glucoside can serve as a hormone replacement therapy.