TRIAMCINOLONE ACETONIDE HEMISUCCINATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C28H35FO9
Molecular Weight	534.5705
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TRIAMCINOLONE ACETONIDE HEMISUCCINATE

Structure Search

SMILES

[H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)COC(=O)CCC(O)=O

InChI

InChIKey=GWKQSBXDFHODNU-UQPSFNCESA-N

InChI=1S/C28H35FO9/c1-24(2)37-21-12-18-17-6-5-15-11-16(30)9-10-25(15,3)27(17,29)19(31)13-26(18,4)28(21,38-24)20(32)14-36-23(35)8-7-22(33)34/h9-11,17-19,21,31H,5-8,12-14H2,1-4H3,(H,33,34)/t17-,18-,19-,21+,25-,26-,27-,28+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5763570

There has been little interest in the biological and pharmacological application of triamcinolone acetonide hemisuccinate. Although, at one time this compound was used as a topical steroid to treat the ocular inflammation.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Ocular inflammation 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5763570	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Topical steroid treatment of ocular inflammation: effectiveness of triamcinolone acetonide hemisuccinate and neomycin.	1969 Feb	5763570
Glucocorticosteroid inhibition of nonphagocytic discharge of lysosomal enzymes from human neutrophils.	1977 Jan-Feb	836339

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

TRIAMCINOLONE ACETONIDE HEMISUCCINATE

Common Name

English

TRIAMCINOLONE-21-HEMISUCCINATE ACETONIDE

Common Name

English

9.ALPHA.-FLUORO-16.ALPHA.-HYDROXYPREDNISOLONE 16.ALPHA.,17.ALPHA.-ACETONIDE 21-HEMISUCCINATE

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 21-(3-CARBOXY-1-OXOPROPOXY)-9-FLUORO-11-HYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (11.BETA.,16.ALPHA.)-

Common Name

English

TRIAMCINOLONE ACETONIDE 21-HEMISUCCINATE [MI]

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 9-FLUORO-11.BETA.,16.ALPHA.,17,21-TETRAHYDROXY-, CYCLIC 16,17-ACETAL WITH ACETONE, 21-(HYDROGEN SUCCINATE)

Common Name

English

TRIAMCINOLONE ACETONIDE 21-HEMISUCCINATE

Common Name

English

SUCCINIC ACID, 21-MONOESTER WITH 9-FLUORO-11.BETA.,16.ALPHA.,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE CYCLIC 16,17-ACETAL WITH ACETONE

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID60953083