SCH-28080

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H15N3O
Molecular Weight	277.3205
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(CC#N)N2C=CC=C(OCC3=CC=CC=C3)C2=N1

InChI

InChIKey=PYKJFEPAUKAXNN-UHFFFAOYSA-N

InChI=1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3

HIDE SMILES / InChI

Molecular Formula	C17H15N3O
Molecular Weight	277.3205
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7104515
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/2993001

SCH-28080 is an inhibitor of H+, K+-ATPase. Administration of SCH-28080 led to significant reduction in the volume, acid output and peptic activity of gastric secretions in a clinical trial.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Potassium-transporting ATPase 31 Target ID: CHEMBL2095173 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2993001	Inhibitor 8297		0.12 µM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Ulcer 5 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7104515	Primary		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Stable expression of gastric proton pump activity at the cell surface.	2002 Jun	12038990

Patents

Sample Use Guides

In Vivo Use Guide

In a clinical trial, SCH-28080 was administered intragastrically via the tube as a 50 ml suspension at dosages of 50 - 200 mg.

Route of Administration: Intragastric

In Vitro Use Guide

Increasing concentrations of SCH 28080 inhibited the H + K + ATPase activity in a preparation of rabbit microsomal membranes. Compound didn't affect the basal (Mg 2+ only) enzyme activity at concentrations as high as 100 uM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:16:05 GMT 2023` Edited by `admin` on `Fri Dec 15 15:16:05 GMT 2023`
Record UNII	00427X161I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SCH-28080

Code

English

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO(1,2-A)-PYRIDINE-3-ACETONITRILE

Systematic Name

English

SCH28080

Code

English

IMIDAZO(1,2-A)PYRIDINE-3-ACETONITRILE, 2-METHYL-8-(PHENYLMETHOXY)-

Systematic Name

English

Code System Code Type Description

CAS

76081-98-6

Created by admin on Fri Dec 15 15:16:05 GMT 2023 , Edited by admin on Fri Dec 15 15:16:05 GMT 2023

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PUBCHEM

108137

Created by admin on Fri Dec 15 15:16:05 GMT 2023 , Edited by admin on Fri Dec 15 15:16:05 GMT 2023

PRIMARY

FDA UNII

00427X161I

Created by admin on Fri Dec 15 15:16:05 GMT 2023 , Edited by admin on Fri Dec 15 15:16:05 GMT 2023

PRIMARY

EPA CompTox

DTXSID10226971

Created by admin on Fri Dec 15 15:16:05 GMT 2023 , Edited by admin on Fri Dec 15 15:16:05 GMT 2023

PRIMARY

Related Record Type Details


					00427X161I

SCH-28080

ACTIVE MOIETY

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/7104515Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/2993001

Originator

Approval Year

Targets

Conditions

Approved Use

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7104515
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/2993001