SCH-28080

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H15N3O
Molecular Weight	277.3205
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(CC#N)N2C=CC=C(OCC3=CC=CC=C3)C2=N1

InChI

InChIKey=PYKJFEPAUKAXNN-UHFFFAOYSA-N

InChI=1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3

HIDE SMILES / InChI

Molecular Formula	C17H15N3O
Molecular Weight	277.3205
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7104515
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/2993001

SCH-28080 is an inhibitor of H+, K+-ATPase. Administration of SCH-28080 led to significant reduction in the volume, acid output and peptic activity of gastric secretions in a clinical trial.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Potassium-transporting ATPase 38 Target ID: CHEMBL2095173 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2993001	Inhibitor 8504		0.12 µM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Ulcer 5 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7104515	Primary		Not Provided 511	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Stable expression of gastric proton pump activity at the cell surface.	2002-06	12038990
Functional expression of the cDNA encoded by the human ATP1AL1 gene.	1996-09	8853415

Patents

Sample Use Guides

In Vivo Use Guide

In a clinical trial, SCH-28080 was administered intragastrically via the tube as a 50 ml suspension at dosages of 50 - 200 mg.

Route of Administration: Intragastric

In Vitro Use Guide

Increasing concentrations of SCH 28080 inhibited the H + K + ATPase activity in a preparation of rabbit microsomal membranes. Compound didn't affect the basal (Mg 2+ only) enzyme activity at concentrations as high as 100 uM.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:52:12 GMT 2025` Edited by `admin` on `Mon Mar 31 17:52:12 GMT 2025`
Record UNII	00427X161I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IMIDAZO(1,2-A)PYRIDINE-3-ACETONITRILE, 2-METHYL-8-(PHENYLMETHOXY)-

Preferred Name

English

SCH-28080

Code

English

2-METHYL-8-(PHENYLMETHOXY)IMIDAZO(1,2-A)-PYRIDINE-3-ACETONITRILE

Systematic Name

English

SCH28080

Code

English

Code System Code Type Description

CAS

76081-98-6

Created by admin on Mon Mar 31 17:52:12 GMT 2025 , Edited by admin on Mon Mar 31 17:52:12 GMT 2025

PRIMARY

PUBCHEM

108137

Created by admin on Mon Mar 31 17:52:12 GMT 2025 , Edited by admin on Mon Mar 31 17:52:12 GMT 2025

PRIMARY

FDA UNII

00427X161I

Created by admin on Mon Mar 31 17:52:12 GMT 2025 , Edited by admin on Mon Mar 31 17:52:12 GMT 2025

PRIMARY

EPA CompTox

DTXSID10226971

Created by admin on Mon Mar 31 17:52:12 GMT 2025 , Edited by admin on Mon Mar 31 17:52:12 GMT 2025

PRIMARY

Related Record Type Details


					00427X161I

SCH-28080

ACTIVE MOIETY

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/7104515Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/2993001

Originator

Approval Year

Targets

Conditions

Approved Use

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7104515
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/2993001