Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H10O2 |
Molecular Weight | 186.2066 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(C=C1)C=C(C=O)C=C2
InChI
InChIKey=VZBLASFLFFMMCM-UHFFFAOYSA-N
InChI=1S/C12H10O2/c1-14-12-5-4-10-6-9(8-13)2-3-11(10)7-12/h2-8H,1H3
Molecular Formula | C12H10O2 |
Molecular Weight | 186.2066 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
6-Methoxy-2-naphthalenecarboxaldehyde is a substrate of aldehyde dehydrogenase enzymes (class I, class II and class III). It was examined as indicator of the aldehyde dehydrogenase (ALDH) activity in human tissue homogenates and accessible body fluids from patients with viral and toxic liver injuries, and tumors. As intermediate, it was used in organic synthesis of enantiomerically enriched R- and S-6-MONCH- (OH)CN and fluorescent substrates for inhibition studies relating to hypertension and vascular inflammation.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2990 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8620059 |
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Target ID: CHEMBL4116 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9025970 |
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Target ID: CHEMBL2363044 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9025970 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Diagnostic | Unknown Approved UseUnknown |
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Diagnostic | Unknown Approved UseUnknown |
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Diagnostic | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Alcohol and aldehyde dehydrogenase activity measured with fluorogenic substrates in the liver of rats poisoned with methanol. | 2001 Apr |
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The activity of class I, II, III, and IV alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in colorectal cancer. | 2004 Jun |
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Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. | 2005 Aug 1 |
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Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with colorectal cancer. | 2007 Dec |
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The activity of class I, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in gastric cancer. | 2007 Feb |
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Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with liver cancer. | 2008 |
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Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with pancreatic cancer. | 2008 Aug |
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Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin. | 2008 Nov 7 |
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Alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase activity in the sera of patients with esophageal cancer. | 2009 Jun |
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A fluorogenic aldehyde bearing a 1,2,3-triazole moiety for monitoring the progress of aldol reactions. | 2009 Mar 20 |
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Salivary aldehyde dehydrogenase - temporal and population variability, correlations with drinking and smoking habits and activity towards aldehydes contained in food. | 2010 |
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(2E)-1-(2,5-Dichloro-3-thien-yl)-3-(6-meth-oxy-2-naphth-yl)prop-2-en-1-one. | 2010 Jun 18 |
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(2E)-1-(3-Bromo-phen-yl)-3-(6-meth-oxy-2-naphth-yl)prop-2-en-1-one. | 2010 Sep 11 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:59:30 GMT 2023
by
admin
on
Fri Dec 15 15:59:30 GMT 2023
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Record UNII |
9244L5L5ZY
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Record Status |
Validated (UNII)
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Record Version |
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76991
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DTXSID3057721
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3453-33-6
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9244L5L5ZY
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admin on Fri Dec 15 15:59:30 GMT 2023 , Edited by admin on Fri Dec 15 15:59:30 GMT 2023
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