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Status:
US Previously Marketed
Source:
XYLO-PFAN by SAVAGE LABS
(1975)
Source URL:
First approved in 1975
Source:
XYLO-PFAN by SAVAGE LABS
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
D-Xylose is a sugar originally isolated from wood. D-Xylose is a colorless to white crystalline powder that is used in food products such as breads, butter, and beverage industry as flavoring agent and sweetener. Specifically, D-Xylose is used to sweeten products intended for use by obese and diabetic customers because it is a non-caloric sweetener. It has a cool and refreshing taste and has the same sweetness as sucrose, and it is often used to sweeten a wide variety of foods and beverages such as spices, meat products, butter, etc. D-Xylose is a sugar widely used as diabetic sweetener in food and beverage. is a sugar first isolated from wood, and named for it. Xylose is classified as a monosaccharide of the aldopentose type, which means that it contains five carbon atoms and includes a formyl functional group. It is derived from hemicellulose, one of the main constituents of biomass. Like most sugars, it can adopt several structures depending on conditions. With its free carbonyl group, it is a reducing sugar. D-xylose absorbtion test has been used for diagnosis of intestinal malabsorption.
Status:
US Previously Marketed
First approved in 1975
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Oxolinic acid is a synthetic quinolone antibiotic related to nalidixic acid. It is authorized in veterinary medicine for use in finfish, calves, pigs, and poultry. It acts by inhibiting bacterial type II topoisomerase activity. Oxolinic acid has been used in human medicine in several countries in the past. Its use in human medicine has largely been replaced by the fluoroquinolone antibiotics.
Status:
US Previously Marketed
Source:
CEFADYL by APOTHECON
(1986)
Source URL:
First approved in 1974
Source:
CEFADYL by APOTHECON
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Cephapirin is a first-generation cephalosporin. Cephapirin has been indicated for the treatment of infections when caused by susceptible strains in respiratory, genitourinary, gastrointestinal, skin and soft tissue, bone and joint infections, septicemia; treatment of susceptible gram-positive bacilli and cocci (never enterococcus); some gram-negative bacilli including E. coli, Proteus, and Klebsiella may be susceptible. Cephapirin is used in veterinary as an intra-uterine antibiotic infusion for the treatment of subacute and chronic endometritis in cows and repeat breeders.
Status:
US Previously Marketed
Source:
VELOSEF by BRISTOL MYERS SQUIBB
(1982)
Source URL:
First approved in 1974
Source:
ANSPOR by GLAXOSMITHKLINE
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Cephradine is a semisynthetic cephalosporin antibiotic. Cephradine is active against the following organisms in vitro: Group A beta-hemolytic streptococci; Staphylococci, including coagulase-positive, coagulase-negative, and penicillinase-producing strains; Streptococcus pneumoniae (formerly Diplococcus pneumoniae); Escherichia coli; Proteus mirabilis; Klebsiella species; Hemophilus influenza. It works by stopping the growth of bacteria. It is used to treat a wide variety of bacterial infections (e.g., skin, ear, respiratory and urinary tract infections). Pseudomembranous colitis has been reported in patients receiving cephradine both orally and intravenously. Diarrhea generally starts 1 to 16 days after starting cephradine therapy. Gastrointestinal side effects have included nausea, vomiting. Hypersensitivity reactions have included rash, urticaria, pruritus, and joint pain. Bacteriostats may interfere with the bactericidal action of cephalosporins in acute infection; other agents, e.g., aminoglycosides, colistin, polymyxins, vancomycin, may increase the possibility of nephrotoxicity.
Status:
US Previously Marketed
Source:
EMETE-CON by ROERIG
(1974)
Source URL:
First approved in 1974
Source:
EMETE-CON by ROERIG
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Benzquinamide also known as BZQ; Emete-con, Emetico, is an antiemetic drug, which was discontinued. That drug was used to prevent and treat nausea and vomiting associated with anesthesia and surgery, administered intramuscularly or intravenously. The mechanism of action is not known, but was made predictions which shown, that in spite of benzquinamide did bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR). It was known, that this activity may partially explain the anxiolytic activity effect of the drug. But the dopamine D2 receptor, which by ligand-set similarity resembles α2-AR is an accepted target for emesis. Then benzquinamide was tested towards to the D2, D3, and D4 receptors. Notwithstanding the fact that the α2-AR values are lower than the D2 values, it was predicted, that D2 activity may be the most relevant for emesis.
Status:
US Previously Marketed
Source:
PERCHLORACAP by MALLINCKRODT
(1974)
Source URL:
First approved in 1974
Source:
PERCHLORACAP by MALLINCKRODT
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Perchloric acid is a strong acid used for complete digestions of organic material. To prevent injury, goggles or face shield, gloves, and apron must be worn. Perchloric acid must not be mixed with any other waste and should be stored separately from the other chemicals.
Status:
US Previously Marketed
Source:
ISOPAQUE 280 by GE HEALTHCARE
(1974)
Source URL:
First approved in 1974
Source:
ISOPAQUE 280 by GE HEALTHCARE
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Meglumine (N-methyl-D-glucamine) is a poorly metabolized derivative of sorbitol that has regulatory acceptance as a benign excipient for drug formulation to increase aqueous solubility of lipophilic drugs and improve their absorption. In conjugated form meglumine is used as a contrast agent.
Status:
US Previously Marketed
Source:
PEPTAVLON by WYETH AYERST
(1974)
Source URL:
First approved in 1974
Source:
PEPTAVLON by WYETH AYERST
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Pentagastrin (trade name Peptavlon) is a cholecystokinin type B (CCK(B)) receptor agonist, which was indicated as a diagnostic aid for evaluation of gastric acid secretory function. It was effective in testing for an acidity (achlorhydria) in patients with suspected pernicious anemia, atrophic gastritis, or gastric carcinoma. It was effective in determining the reduction in acid output after operations for peptic ulcer, such as vagotomy or gastric resection. Pentagastrin was also indicated as a diagnostic aid in testing for gastric hypersecretion in patients with suspected duodenal ulcer or postoperative stomal ulcer, and for the diagnosis of Zollinger-Ellison tumor. Peptavlon was discontinued, Federal Register determined that product was not discontinued or withdrawn for safety or efficacy reasons. In addition was shown, that Pentagastrin may release adrenocorticotropin (ACTH) and cortisol through direct pharmacological action, perhaps enhanced on first exposure by psychologically mediated novelty effects. Novelty, per se, is not likely the primary mediator of the hypothalamic-pituitary-adrenal (HPA) response. This model may be useful for further study of cognitive-emotional modulators of HPA axis activity.
Status:
US Previously Marketed
Source:
DICOPAC KIT by GE HEALTHCARE
(1974)
Source URL:
First approved in 1974
Source:
DICOPAC KIT by GE HEALTHCARE
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Cyanocobalamin Co 57 is a manufactured form of radiolabeled vitamin B indicated as an adjunct in diagnosing intestinal cyanocobalamin malabsorption syndromes due to lack of intrinsic factor (IF) or other defects in intestinal absorption (e.g., blind loop syndrome and diverticulitis, celiac disease, Crohn's disease, lesions in the small intestine, severe pancreatitis, tropical sprue).
Status:
US Previously Marketed
Source:
ISMOTIC by ALCON
(1974)
Source URL:
First approved in 1974
Source:
ISMOTIC by ALCON
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Isosorbide is an effective hyperosmotic agent which can be administered orally without gastrointestinal irritation. It is absorbed quantitatively and more than 95% of the administered dose is excreted unchanged in the urine. Oral administration of a 50% solution to rabbits or man results in prompt increases in osmolarity of the serum and profound decreases in intraocular pressure. The drug proves useful in acute primary and secondary glaucomas, and as preoperative medication for various surgical procedures including cataract extraction, retinal detachment, corneal transplant, and glaucoma operations.