U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ABSOLUTE
Molecular Formula C7H17NO5
Molecular Weight 195.2136
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEGLUMINE

SMILES

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

InChIKey=MBBZMMPHUWSWHV-BDVNFPICSA-N
InChI=1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1

HIDE SMILES / InChI
Molecular Formula C7H17NO5
Molecular Weight 195.2136
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Meglumine (N-methyl-D-glucamine) is a poorly metabolized derivative of sorbitol that has regulatory acceptance as a benign excipient for drug formulation to increase aqueous solubility of lipophilic drugs and improve their absorption. In conjugated form meglumine is used as a contrast agent.

Approval Year

1974
167
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8583
ISOPAQUE 280

Approved Use

Unknown

Launch Date

1974
Sourcing

Sourcing

Vendor/AggregatorIDURL
3B Scientific (Wuhan) Corp
3B3-033309
http://www.3bsc.com/index/pro_info.php?id=54573
AA Blocks
AA003T4I
https://www.aablocks.com/goods/Goods/detail?id=AA003T4I
Aaron Chemicals
AR003TWA
http://www.aaronchem.com/6284-40-8
abcr GmbH
AB138647
http://www.abcr.com/shop/en/AB138647
AbMole Bioscience
M5766
http://www.abmole.com/products/meglumine.html
Acadechem
ACDS-064648
http://www.acadechemical.com/product/139347
Achemtek
0104-003527
http://www.achemtek.com/6284-40-8
Acros Organics
AC126840025
https://www.fishersci.com/shop/products/n-methyl-d-glucamine-99-acros-organics-3/AC126840025
Acros Organics
AC126841000
https://www.fishersci.com/shop/products/n-methyl-d-glucamine-99-acros-organics-1/AC126841000
Acros Organics
AC126845000
https://www.fishersci.com/shop/products/n-methyl-d-glucamine-99-acros-organics-1/AC126845000
AEchem Scientific Corp., USA
AE065730
https://www.aechemsc.com/info_products/AE065730.php
AHH Chemical co.,ltd
MB-01145
http://www.ahhchemical.com/product/MB-01145.html
AHH Chemical co.,ltd
MT-57074
http://www.ahhchemical.com/product/MT-57074.html
AK Scientific, Inc. (AKSCI)
968804
http://www.aksci.com/item_detail.php?cat=968804
Alfa Aesar
L14282
https://www.alfa.com/en/catalog/L14282/
Alfa Chemistry
3521-84-4
https://www.alfa-chemistry.com/cas_3521-84-4.htm
Ambeed
A112809
https://www.ambeed.com/products/6284-40-8.html
Angene
AGN-PC-0ODWA2
http://www.angenechemical.com/productshow/AGN-PC-0ODWA2.html
ApexBio Technology
B1965
http://www.apexbt.com/meglumine.html
Aronis
ARONIS27014
http://www.aronis.ru/store/index.php?main_page=product_info&cPath=1&products_id=19910
Aurora Fine Chemicals LLC
A13.110.471
http://online.aurorafinechemicals.com/info?ID=A13.110.471
Aurora Fine Chemicals LLC
K06.253.416
http://online.aurorafinechemicals.com/info?ID=K06.253.416
Avantor Inc
101095-412
https://us.vwr.com/store/product/7889462/d-n-methylglucamine
BLD Pharm
BD34404
http://www.bldpharm.com/products/6284-40-8.html
Boerchem
BC211218
http://www.boerchem.com/?product_35913.html
Chem Scene
CS-2384
http://www.chemscene.com/6284-40-8.html
ChemMol
1201590
http://www.chemmol.com/chemmol/1201590.html
ChemMol
30105854
http://www.chemmol.com/chemmol/30105854.html
ChemMol
30111614
http://www.chemmol.com/chemmol/30111614.html
ChemMol
44004304
http://www.chemmol.com/chemmol/44004304.html
ChemMol
99075520
http://www.chemmol.com/chemmol/99075520.html
Chemspace
CSSB00000067251
https://chem-space.com/CSSB00000067251
China MainChem Co., Ltd
6284-40-8
https://www.mainchem.com/product/cas-6284-40-8-supplier-distributor/
CSNpharm
CSN16439
https://www.csnpharm.com/products/meglumine.html
DC Chemicals
DC33508
http://www.dcchemicals.com//product_show-1-Deoxy-1-methylamino-D-glucitol.html
eNovation Chemicals
D141525
https://www.enovationchem.com/ProductDetails.asp?ProductID=D141525
eNovation Chemicals
D379640
http://www.enovationchem.com/productDetails.asp?productID=D379640
eNovation Chemicals
D603625
https://www.enovationchem.com/ProductDetails.asp?ProductID=D603625
eNovation Chemicals
D670102
https://www.enovationchem.com/ProductDetails.asp?ProductID=D670102
eNovation Chemicals
D926917
https://www.enovationchem.com/ProductDetails.asp?ProductID=D926917
FondChemical
FDB-1619
http://www.fondchemical.com/cpshow_cid_8_pid_807.html
Hairui
HR132075
http://www.hairuichem.com/en/product/6284-40-8.html
Lab Network
LN00198094
https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00198094
LGC Standards
DRE-A14861330AL-100
https://www.lgcstandards.com/US/en/p/DRE-A14861330AL-100
LGC Standards
DRE-C14861330
https://www.lgcstandards.com/US/en/p/DRE-C14861330
LGC Standards
LGCFOR3394.00
https://www.lgcstandards.com/US/en/p/LGCFOR3394.00
LGC Standards
MM3394.00
https://www.lgcstandards.com/US/en/p/MM3394.00
Matrix Scientific
97464
https://www.matrixscientific.com/097464.html
MedChem Express
HY-B0342
https://www.medchemexpress.com/meglumine.html
MuseChem
A000666
https://www.musechem.com/product/A000666.html
Oakwood
235559
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=116558&ExtHyperLink=1
Oakwood
50328
http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=44182&ExtHyperLink=1
Selleck Chemicals
S1974
http://www.selleckchem.com/products/meglumine.html
Sigma-Aldrich
1379140_USP
https://www.sigmaaldrich.com/catalog/product/usp/1379140?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
66930_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/66930?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
M2004_SIGMA
https://www.sigmaaldrich.com/catalog/product/sigma/m2004?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
M9179_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/m9179?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
PHR1324_SIAL
https://www.sigmaaldrich.com/catalog/product/sial/phr1324?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech
S048991
http://www.sinfoobiotech.com/product/1052389
Smolecule
S534912
http://www.smolecule.com/products/s534912
TCI (Tokyo Chemical Industry)
M0227
http://www.tcichemicals.com/eshop/en/us/commodity/M0227/index.html
THE BioTek
bt-274632
https://www.thebiotek.com/product/inhibitors/bt-274632
VladaChem
VL143343
https://www.vladachem.com/product.php?products=6284-40-8
VladaChem
VL270314-100G
https://www.vladachem.com/product.php?products=6284-40-8
Yuhao Chemical
LT5555
http://www.chemyuhao.com/6284-40-8.html
PubMed

PubMed

TitleDatePubMed
A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109.
2001 Aug 17
Agonist-stimulated calcium decreases in ovine ciliated airway epithelial cells: role of mitochondria.
2001 Feb 15
Inwardly rectifying K(+) channels in spermatogenic cells: functional expression and implication in sperm capacitation.
2001 Jun 1
[Infiltrated cutaneous leishmaniasis and sporotrichosis caused by Leishmania major. First Senegalese case].
2001 Mar
Dynamics of the antibody response in patients with therapeutic or spontaneous cure of American cutaneous leishmaniasis.
2001 Mar-Apr
Mechanism underlying slow kinetics of the OFF gating current in Shaker potassium channel.
2001 May
Comparative effects of ionic and nonionic iodinated low-osmolar contrast media on platelet function with the PFA-100 (platelet function analyzer).
2001 May
Two open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels.
2001 May 15
Choline blocks AMPA-induced dark cell degeneration of Purkinje neurons: potential role of the alpha7 nicotinic receptor.
2001 May 18
In vitro activity of pentavalent antimony derivatives on promastigotes and intracellular amastigotes of Leishmania infantum strains from humans and dogs in Spain.
2001 May 25
Background osmolyte current involved in cell volume regulation of neuroblastoma x glioma hybrid NG108-15 cells.
2001 Sep
Visceral leishmaniasis with pericarditis in an HIV-infected patient.
2002
Gender differences in vascular smooth muscle reactivity to increases in extracellular sodium salt.
2002 Feb
Dual effect of blocking agents on Ca2+-activated Cl(-) currents in rabbit pulmonary artery smooth muscle cells.
2002 Feb 15
Cytostatic potential of novel agents that inhibit the regulation of intracellular pH.
2002 Jul 15
Evaluation of a rapid immunochromatographic test for serodiagnosis of visceral leishmaniasis.
2002 Jun
Phospholipase C-mediated signalling is not required for histamine-induced catecholamine secretion from bovine chromaffin cells.
2002 Jun
Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification.
2002 Mar 1
[Cutaneous leishmaniasis of the lid].
2002 May
Patents

Patents

04791126
4
05319140
3
05438092
3
06232313
4
08557893
3
JP2002234871A
13
JP2002511777A
420
JP2003518131A
5
JP2004161729A
3
JP2006528156A
10
JP2008505142A
10
JP2010132643A
3
JP2011508747A
62
JP4149804B2
5
JP4738554B2
3
JPH05112528A
3
JPS60142969A
4

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:25:47 GMT 2025
Edited
by admin
on Mon Mar 31 18:25:47 GMT 2025
Record UNII
6HG8UB2MUY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
METHYLGLUCAMINE
INCI  
INCI  
Preferred Name English
MEGLUMINE
EP   II   INN   MART.   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
Common Name English
MEGLUMINE [ORANGE BOOK]
Common Name English
MEGLUMINE [II]
Common Name English
D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-
Common Name English
D(-)-N-METHYLGLUCAMINE
Brand Name English
Meglumine [WHO-DD]
Common Name English
MEGLUMINE [EP MONOGRAPH]
Common Name English
NSC-52907
Code English
MEGLUMINE [JAN]
Common Name English
MEGLUMINE [USP-RS]
Common Name English
N-METHYLSORBITYLAMINE
Common Name English
MEGLUMINE [VANDF]
Common Name English
MEGLUMINUM [WHO-IP LATIN]
Common Name English
meglumine [INN]
Common Name English
MEGLUMINE [WHO-IP]
Common Name English
N-METHYLGLUCAMINE [MI]
Common Name English
MEGLUMINE [MART.]
Common Name English
MEGLUMINE [USP MONOGRAPH]
Common Name English
NSC-7391
Code English
Classification Tree Code System Code
NCI_THESAURUS C390
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
Code System Code Type Description
ECHA (EC/EINECS)
228-506-9
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
NCI_THESAURUS
C61828
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
SMS_ID
100000081443
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
DAILYMED
6HG8UB2MUY
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
EPA CompTox
DTXSID0023244
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
EVMPD
SUB08715MIG
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
FDA UNII
6HG8UB2MUY
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
WIKIPEDIA
MEGLUMINE
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
CAS
6284-40-8
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
MESH
D008536
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
DRUG CENTRAL
5194
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
NSC
7391
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
NSC
52907
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
ChEMBL
CHEMBL1200570
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
INN
4205
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
RS_ITEM_NUM
1379140
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
RXCUI
6704
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY RxNorm
PUBCHEM
8567
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
MEGLUMINE
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY Description: A white or almost white, crystalline powder; odourless or almost odourless. Solubility: Freely soluble in water; slightly soluble in ethanol (~750 g/l) TS; practically insoluble in ether R.Category: Used in the preparation of meglumine amidotrizoate and meglumine iotroxate as radiocontrast media. Storage: Meglumine should be kept in a well-closed container.Requirements: Meglumine contains not less than 99.0% and not more than the equivalent of 100.5% of C7H17NO5, calculated with reference to the dried substance.
MERCK INDEX
m7420
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY Merck Index
CHEBI
59732
Created by admin on Mon Mar 31 18:25:47 GMT 2025 , Edited by admin on Mon Mar 31 18:25:47 GMT 2025
PRIMARY
Related Record Type Details
Structure of MEGLUMINE ANTIMONIATE
SALT/SOLVATE -> PARENT
Structure of IOCARMATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of METRIZOATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of IODOXAMATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of IOSEFAMATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of TIPRINAST MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of IODAMIDE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of MEGLUMINE ACETRIZOATE
SALT/SOLVATE -> PARENT
Structure of METHYLGLUCAMINE ASCORBATE
SALT/SOLVATE -> PARENT
Structure of Tafamidis Meglumine
SALT/SOLVATE -> PARENT
Structure of BEVIRIMAT DIMEGLUMINE
SALT/SOLVATE -> PARENT
Structure of IOTROXATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of NIACIN MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of MEGLUMINE SODIUM SUCCINATE
SALT/SOLVATE -> PARENT
Structure of TETRAZOLAST MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of CI-988 MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of DELAFLOXACIN MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of GW-468816 MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of MEGLUMINE NALIDIXIC ACID
SALT/SOLVATE -> PARENT
Structure of DIATRIZOATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of Azosemide meglumine
SALT/SOLVATE -> PARENT
Structure of Tafamidis Meglumine
SALT/SOLVATE -> PARENT
Structure of IOTHALAMATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of MEGLUMINE IOXITHALAMATE
SALT/SOLVATE -> PARENT
Structure of TETRAZOLAST MEGLUMINE ANHYDROUS
SALT/SOLVATE -> PARENT
Structure of THEOPHYLLINE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of 5,5'-(DODECANEDIOYLDIIMINO)-BIS(2,4,6-TRIIODO-N-METHYLISOPHTHALAMATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of IOXAGLATE SODIUM MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of GADOTERATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of IOGLYCAMATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of IOXAGLATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of 2,3,4-TRIMETHOXY-ESTRA-1,3,5(10),8-TETRAEN-17-OL, SULFATE, (17.BETA.)-(±)- N-METHYL-D-GLUCAMINE
SALT/SOLVATE -> PARENT
Structure of SALICYLATE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of IODIPAMIDE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of METHYLGLUCAMINE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
Structure of IOSULAMIDE MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of FLUNIXIN MEGLUMINE
SALT/SOLVATE -> PARENT
Structure of MELOXICAM MEGLUMINE MONOHYDRATE
SALT/SOLVATE -> PARENT
Structure of MEGLUMINE IOGLICATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of MEGLUMINE
ACTIVE MOIETY
NIH
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