U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C7H17NO5
Molecular Weight 195.2136
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEGLUMINE

SMILES

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

InChIKey=MBBZMMPHUWSWHV-BDVNFPICSA-N
InChI=1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1

HIDE SMILES / InChI

Molecular Formula C7H17NO5
Molecular Weight 195.2136
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Meglumine (N-methyl-D-glucamine) is a poorly metabolized derivative of sorbitol that has regulatory acceptance as a benign excipient for drug formulation to increase aqueous solubility of lipophilic drugs and improve their absorption. In conjugated form meglumine is used as a contrast agent.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
ISOPAQUE 280

Approved Use

Unknown

Launch Date

1974
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
[Epidemic outbreak of tegumentary leishmaniasis in Puerto Esperanza, Misiones, 1998].
2001
Leishmania infantum-specific IgG, IgG1 and IgG2 antibody responses in healthy and ill dogs from endemic areas. Evolution in the course of infection and after treatment.
2001 Apr 19
Amino acid transporters involved in luminal transport of mercuric conjugates of cysteine in rabbit proximal tubule.
2001 Aug
Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle.
2001 Aug
Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator.
2001 Dec 1
Levels of nitric oxide in the heart after experimental myocardial ischemia.
2001 Jan
Novel voltage-dependent non-selective cation conductance in murine colonic myocytes.
2001 Jun 1
[Effect of intralesional treatment with emetine hydrochloride on Leishmania (Viannia) braziliensis in hamsters].
2001 Mar
Dynamics of the antibody response in patients with therapeutic or spontaneous cure of American cutaneous leishmaniasis.
2001 Mar-Apr
Molecular identification of a TTX-sensitive Ca(2+) current.
2001 May
Choline blocks AMPA-induced dark cell degeneration of Purkinje neurons: potential role of the alpha7 nicotinic receptor.
2001 May 18
A standing Na+ conductance in rat carotid body type I cells.
2001 May 25
In vitro activity of pentavalent antimony derivatives on promastigotes and intracellular amastigotes of Leishmania infantum strains from humans and dogs in Spain.
2001 May 25
Nitric oxide generation in aqueous solutions of cigarette smoke and approaches to its origin.
2001 Nov
Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: therapeutic response to meglumine antimoniate.
2001 Nov
Ca2+-dependent membrane currents in vascular smooth muscle cells of the rabbit.
2001 Oct 12
Antimony(V) complex formation with adenine nucleosides in aqueous solution.
2002 Apr 15
Gender differences in vascular smooth muscle reactivity to increases in extracellular sodium salt.
2002 Feb
Characterization of the maitotoxin-activated cationic current from human skin fibroblasts.
2002 Jan 1
Intrarenal detection of nitric oxide using electron spin resonance spectroscopy in hypertensive lipopolysaccharide-treated rats.
2002 Jul
Chemotherapy of canine leishmaniosis.
2002 Jul 2
Evaluation of a rapid immunochromatographic test for serodiagnosis of visceral leishmaniasis.
2002 Jun
An outbreak of cutaneous leishmaniasis among soldiers in Belém, Pará State, Brazil, caused by Leishmania (Viannia) lindenbergi n. sp. A new leishmanial parasite of man in the Amazon region.
2002 Mar
Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification.
2002 Mar 1
Nonselective cation conductance activated by muscarinic and purinergic receptors in rat spiral ganglion neurons.
2002 May
In vitro susceptibility to pentavalent antimony in Leishmania infantum strains is not modified during in vitro or in vivo passages but is modified after host treatment with meglumine antimoniate.
2002 May 2
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:21:07 GMT 2023
Edited
by admin
on Fri Dec 15 16:21:07 GMT 2023
Record UNII
6HG8UB2MUY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MEGLUMINE
EP   II   INN   MART.   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL
Common Name English
MEGLUMINE [ORANGE BOOK]
Common Name English
MEGLUMINE [II]
Common Name English
METHYLGLUCAMINE
INCI  
INCI  
Official Name English
D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-
Common Name English
D(-)-N-METHYLGLUCAMINE
Brand Name English
Meglumine [WHO-DD]
Common Name English
MEGLUMINE [EP MONOGRAPH]
Common Name English
NSC-52907
Code English
MEGLUMINE [JAN]
Common Name English
MEGLUMINE [USP-RS]
Common Name English
N-METHYLSORBITYLAMINE
Common Name English
MEGLUMINE [VANDF]
Common Name English
MEGLUMINUM [WHO-IP LATIN]
Common Name English
meglumine [INN]
Common Name English
MEGLUMINE [WHO-IP]
Common Name English
N-METHYLGLUCAMINE [MI]
Common Name English
MEGLUMINE [MART.]
Common Name English
METHYLGLUCAMINE [INCI]
Common Name English
MEGLUMINE [USP MONOGRAPH]
Common Name English
NSC-7391
Code English
Classification Tree Code System Code
NCI_THESAURUS C390
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
Code System Code Type Description
ECHA (EC/EINECS)
228-506-9
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
NCI_THESAURUS
C61828
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
SMS_ID
100000081443
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
DAILYMED
6HG8UB2MUY
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
EPA CompTox
DTXSID0023244
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
EVMPD
SUB08715MIG
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
FDA UNII
6HG8UB2MUY
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
WIKIPEDIA
MEGLUMINE
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
CAS
6284-40-8
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
MESH
D008536
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
DRUG CENTRAL
5194
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
NSC
7391
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
NSC
52907
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
ChEMBL
CHEMBL1200570
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
INN
4205
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
RS_ITEM_NUM
1379140
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
RXCUI
6704
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY RxNorm
PUBCHEM
8567
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
MEGLUMINE
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY Description: A white or almost white, crystalline powder; odourless or almost odourless. Solubility: Freely soluble in water; slightly soluble in ethanol (~750 g/l) TS; practically insoluble in ether R.Category: Used in the preparation of meglumine amidotrizoate and meglumine iotroxate as radiocontrast media. Storage: Meglumine should be kept in a well-closed container.Requirements: Meglumine contains not less than 99.0% and not more than the equivalent of 100.5% of C7H17NO5, calculated with reference to the dried substance.
MERCK INDEX
m7420
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY Merck Index
CHEBI
59732
Created by admin on Fri Dec 15 16:21:08 GMT 2023 , Edited by admin on Fri Dec 15 16:21:08 GMT 2023
PRIMARY
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