METRIZOATE MEGLUMINE

US Previously Marketed

First approved in 1973

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C12H11I3N2O4.C7H17NO5
Molecular Weight	823.1537
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CN(C(C)=O)C1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I

InChI

InChIKey=TXKOGNLDVKUFSI-WZTVWXICSA-N

InChI=1S/C12H11I3N2O4.C7H17NO5/c1-4(18)16-10-7(13)6(12(20)21)8(14)11(9(10)15)17(3)5(2)19;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-3H3,(H,16,18)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

HIDE SMILES / InChI

Molecular Formula	C12H11I3N2O4
Molecular Weight	627.9402
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C7H17NO5
Molecular Weight	195.2136
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/Metrizoic_acid#section=Top

Metrizoic acid is a diagnostic radiopaque that usually occurs as the sodium salt. The mechanism of action of metrizoic acid is as a X-Ray Contrast Activity.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Contrast agent 13 Sources: http://www.ncbi.nlm.nih.gov/pubmed/616209	Diagnostic		Approved 8429	ISOPAQUE 280 Approved Use Unknown Launch Date 1.36511996E11

C_max

Value	Dose	Co-administered	Analyte	Population
300 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3375780/	2310 mg single, intravenous dose: 2310 mg route of administration: Intravenous experiment type: SINGLE co-administered:		METRIZOIC ACID serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
250 μg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3375780/	2310 mg single, intravenous dose: 2310 mg route of administration: Intravenous experiment type: SINGLE co-administered:		METRIZOIC ACID serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
75.1 min EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3375780/	2310 mg single, intravenous dose: 2310 mg route of administration: Intravenous experiment type: SINGLE co-administered:		METRIZOIC ACID serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
100% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/3375780/	2310 mg single, intravenous dose: 2310 mg route of administration: Intravenous experiment type: SINGLE co-administered:		METRIZOIC ACID serum	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: UNKNOWN

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:34847	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:34847
ChemicalBook	CB1775662	https://www.chemicalbook.com/ChemicalProductProperty_EN_CB1775662
MolPort	MolPort-006-147-732	https://www.molport.com/shop/molecule-link/MolPort-006-147-732
ZINC	ZINC000003831116	http://zinc15.docking.org/substances/ZINC000003831116
eMolecules	736293	https://www.emolecules.com/cgi-bin/more?vid=736293

PubMed

Title	Date	PubMed
Increased ventricular fibrillation during coronary arteriography with a new contrast medium preparation.	1971 Oct	4106954
Adverse general reactions to high doses of methylglucamine-based contrast media.	1974 Sep	4424022
ECG changes and arrhythmias induced by ionic and non-ionic contrast media during coronary arteriography in dogs.	1978 May-Jun	711398
Selective injection of iopentol, iohexol and metrizoate into the left coronary artery of the dog. Induction of ventricular fibrillation and decrease of aortic pressure.	1987	2980315

Sample Use Guides

In Vivo Use Guide

0.35 mg/ml; 140.1 mg/ml; 461.8 mg/ml

Route of Administration: Intravascular

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 14:57:37 UTC 2023` Edited by `admin` on `Fri Dec 15 14:57:37 UTC 2023`
Record UNII	RJY6JR42WQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METRIZOATE MEGLUMINE

Common Name

English

MEGLUMINE METRIZOATE

Common Name

English

MEGLUMINE METRIZOATE [ORANGE BOOK]

Common Name

English

BENZOIC ACID, 3-(ACETYLAMINO)-5-(ACETYLMETHYLAMINO)-2,4,6-TRIIODO-, COMPD. WITH D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)- (1:1)

Common Name

English

MEGLUMINE METRIZOATE [MART.]

Common Name

English

Meglumine metrizoate [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C390