IODOXAMATE MEGLUMINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C26H26I6N2O10.2C7H17NO5
Molecular Weight	1678.346
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)C1=C(I)C=C(I)C(NC(=O)CCOCCOCCOCCOCCC(=O)NC2=C(I)C=C(I)C(C(O)=O)=C2I)=C1I

InChI

InChIKey=LNBGFESBSAEKAE-VRWDCWMNSA-N

InChI=1S/C26H26I6N2O10.2C7H17NO5/c27-13-11-15(29)23(21(31)19(13)25(37)38)33-17(35)1-3-41-5-7-43-9-10-44-8-6-42-4-2-18(36)34-24-16(30)12-14(28)20(22(24)32)26(39)40;2*1-8-2-4(10)6(12)7(13)5(11)3-9/h11-12H,1-10H2,(H,33,35)(H,34,36)(H,37,38)(H,39,40);2*4-13H,2-3H2,1H3/t;2*4-,5+,6+,7+/m.00/s1

HIDE SMILES / InChI

Molecular Formula	C26H26I6N2O10
Molecular Weight	1287.9189
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C7H17NO5
Molecular Weight	195.2136
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6894722 | https://www.ncbi.nlm.nih.gov/pubmed/1242871 | https://www.ncbi.nlm.nih.gov/pubmed/182003

Iodoxamic acid (previously sold under the brand name Cholovue) is an organoiodine compound that was used as a contrast medium. It is intravenous cholecystocholangiographic agent. It features both a high iodine content as well as several hydrophilic groups.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Biliary tract diseases 11 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6894722 https://www.ncbi.nlm.nih.gov/pubmed/1242871 https://www.ncbi.nlm.nih.gov/pubmed/182003	Diagnostic		Approved 8429	CHOLOVUE Approved Use Contrast medium for biliary-tract radiography

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1UBY
BOC Sciences	31127-82-9	https://www.bocsci.com/iodoxamic-acid-cas-31127-82-9-item-106766.html
ChemMol	99069281	http://www.chemmol.com/chemmol/99069281.html
Chemieliva Pharmaceutical Co., Ltd	PBCM1269562
NovoSeek	35740
PubChem	35740	https://pubchem.ncbi.nlm.nih.gov/compound/35740
Smolecule	S563848	https://www.smolecule.com/products/s563848

PubMed

Title	Date	PubMed
A new contrast medium for cholangio-cholecystography: meglumine iodoxamete.	1975 Sep	1242871
Double-blind comparison of meglumine lodoxamate (Cholovue) and meglumine iodipamide (Cholografin).	1976 Aug	182003
Intravenous cholangiography by bolus injection of meglumine iotroxamate and meglumine iodoxamate: a comparative trial of two new contrast media.	1981 Jul	6894722

Patents

Sample Use Guides

In Vivo Use Guide

A total of 90 patients were given an intravenous injection of 20 ml of 40% meglumine iodoxamate (iodoxamic acid) containing 183 mg/mI of organically bound iodine. The 20 ml dose was given intravenously over a 10 mm interval.

Route of Administration: Intravenous

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:21:29 GMT 2023` Edited by `admin` on `Fri Dec 15 16:21:29 GMT 2023`
Record UNII	CIX5G6J9R1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IODOXAMATE MEGLUMINE

Official Name

English

MEGLUMINE IODOXAMATE [MART.]

Common Name

English

IODOXAMATE MEGLUMINE [USAN]

Common Name

English

BENZOIC ACID, 3,3'-((1,16-DIOXO-4,7,10,13-TETRAOXAHEXADECANE-1,16-DIYL)DIIMINO)BIS(2,4,6-TRIIODO-, COMPOUND WITH 1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL (1:2)

Common Name

English

3,3'-(ETHYLENEBIS(OXYETHYLENEOXYETHYLENECARBONYLIMINO))BIS(2,4,6-TRIIODOBENZOIC ACID) COMPOUND WITH 1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL (1:2)

Common Name

English

IODOXAMATE MEGLUMINE [ORANGE BOOK]

Common Name

English

MEGLUMINE IODOXAMATE

Common Name

English

Iodoxamate meglumine [WHO-DD]

Common Name

English

CHOLOVUE

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28500