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Details

Stereochemistry ABSOLUTE
Molecular Formula C26H26I6N2O10.2C7H17NO5
Molecular Weight 1678.346
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IODOXAMATE MEGLUMINE

SMILES

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)C1=C(I)C=C(I)C(NC(=O)CCOCCOCCOCCOCCC(=O)NC2=C(I)C=C(I)C(C(O)=O)=C2I)=C1I

InChI

InChIKey=LNBGFESBSAEKAE-VRWDCWMNSA-N
InChI=1S/C26H26I6N2O10.2C7H17NO5/c27-13-11-15(29)23(21(31)19(13)25(37)38)33-17(35)1-3-41-5-7-43-9-10-44-8-6-42-4-2-18(36)34-24-16(30)12-14(28)20(22(24)32)26(39)40;2*1-8-2-4(10)6(12)7(13)5(11)3-9/h11-12H,1-10H2,(H,33,35)(H,34,36)(H,37,38)(H,39,40);2*4-13H,2-3H2,1H3/t;2*4-,5+,6+,7+/m.00/s1

HIDE SMILES / InChI

Molecular Formula C26H26I6N2O10
Molecular Weight 1287.9189
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C7H17NO5
Molecular Weight 195.2136
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Iodoxamic acid (previously sold under the brand name Cholovue) is an organoiodine compound that was used as a contrast medium. It is intravenous cholecystocholangiographic agent. It features both a high iodine content as well as several hydrophilic groups.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
CHOLOVUE

Approved Use

Contrast medium for biliary-tract radiography
PubMed

PubMed

TitleDatePubMed
A new contrast medium for cholangio-cholecystography: meglumine iodoxamete.
1975 Sep
Double-blind comparison of meglumine lodoxamate (Cholovue) and meglumine iodipamide (Cholografin).
1976 Aug
Intravenous cholangiography by bolus injection of meglumine iotroxamate and meglumine iodoxamate: a comparative trial of two new contrast media.
1981 Jul
Patents

Sample Use Guides

In Vivo Use Guide
A total of 90 patients were given an intravenous injection of 20 ml of 40% meglumine iodoxamate (iodoxamic acid) containing 183 mg/mI of organically bound iodine. The 20 ml dose was given intravenously over a 10 mm interval.
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:21:29 GMT 2023
Edited
by admin
on Fri Dec 15 16:21:29 GMT 2023
Record UNII
CIX5G6J9R1
Record Status Validated (UNII)
Record Version
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Name Type Language
IODOXAMATE MEGLUMINE
ORANGE BOOK   USAN   WHO-DD  
USAN  
Official Name English
MEGLUMINE IODOXAMATE [MART.]
Common Name English
IODOXAMATE MEGLUMINE [USAN]
Common Name English
BENZOIC ACID, 3,3'-((1,16-DIOXO-4,7,10,13-TETRAOXAHEXADECANE-1,16-DIYL)DIIMINO)BIS(2,4,6-TRIIODO-, COMPOUND WITH 1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL (1:2)
Common Name English
3,3'-(ETHYLENEBIS(OXYETHYLENEOXYETHYLENECARBONYLIMINO))BIS(2,4,6-TRIIODOBENZOIC ACID) COMPOUND WITH 1-DEOXY-1-(METHYLAMINO)-D-GLUCITOL (1:2)
Common Name English
IODOXAMATE MEGLUMINE [ORANGE BOOK]
Common Name English
MEGLUMINE IODOXAMATE
MART.  
Common Name English
Iodoxamate meglumine [WHO-DD]
Common Name English
CHOLOVUE
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C28500
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
Code System Code Type Description
FDA UNII
CIX5G6J9R1
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
PRIMARY
PUBCHEM
23620848
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201324
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
PRIMARY
SMS_ID
100000077381
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
PRIMARY
EVMPD
SUB14253MIG
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
PRIMARY
DRUG BANK
DBSALT002655
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
PRIMARY
CAS
51764-33-1
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
PRIMARY
NCI_THESAURUS
C65935
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
PRIMARY
EPA CompTox
DTXSID301027216
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
PRIMARY
ECHA (EC/EINECS)
257-398-6
Created by admin on Fri Dec 15 16:21:29 GMT 2023 , Edited by admin on Fri Dec 15 16:21:29 GMT 2023
PRIMARY
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ACTIVE MOIETY