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Details

Stereochemistry ABSOLUTE
Molecular Formula C6H10O4
Molecular Weight 146.1412
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ISOSORBIDE

SMILES

[H][C@]12OC[C@@H](O)[C@@]1([H])OC[C@@H]2O

InChI

InChIKey=KLDXJTOLSGUMSJ-JGWLITMVSA-N
InChI=1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1

HIDE SMILES / InChI

Description

Isosorbide is an effective hyperosmotic agent which can be administered orally without gastrointestinal irritation. It is absorbed quantitatively and more than 95% of the administered dose is excreted unchanged in the urine. Oral administration of a 50% solution to rabbits or man results in prompt increases in osmolarity of the serum and profound decreases in intraocular pressure. The drug proves useful in acute primary and secondary glaucomas, and as preoperative medication for various surgical procedures including cataract extraction, retinal detachment, corneal transplant, and glaucoma operations.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
ISMOTIC
Palliative
ISMOTIC

Cmax

ValueDoseCo-administeredAnalytePopulation
2.16 μg/mL
100 mg 1 times / day steady-state, oral
ISOSORBIDE plasma
Homo sapiens

T1/2

ValueDoseCo-administeredAnalytePopulation
9 h
100 mg 1 times / day steady-state, oral
ISOSORBIDE plasma
Homo sapiens

PubMed

Sample Use Guides

In Vivo Use Guide
The recommended initial dose is 1.5 gm/kg body weight (equivalent to 1.5 ml/lb. of body weight).
Route of Administration: Oral
In Vitro Use Guide
Unknown