ITROCINONIDE is a synthetic corticosteroid which showed no signs of systemic activity (cortisol depression).

Isbufylline is a xanthine derivative. This compound exhibits remarkable antibronchospastic properties both in in vitro and in vivo (after oral or intravenous administration) experimental models. Isbufylline is significantly more effective than theophylline in antagonizing bronchospasms elicited by spasmogens (capsaicin, arachidonic acid, PAF and antigen) which mainly act by a local release of biologically active substances proposed to be involved in the pathogenesis of asthma. Isbufylline, unlike theophylline, possesses little or no CNS excitatory properties. Isbufylline exerts a greater inhibitory activity than theophylline on total phosphodiesterase activity in the rat lung.

Imcarbofos is diphosphoricthioamide derivative patented by American Cyanamid Co as anthelmintics agent.

Imagabalin is a ligand to the α(2)δ subunit of voltage-sensitive calcium channel and was developed to treat generalized anxiety disorder. Imagabalin was involved in phase III clinical trials when was made a decision to terminate all studies. However, this decision was not based on any safety concerns.

Ilepcimide, a piperine derivative, was studied in China as an anticonvulsant agent for the treatment of seizures in epilepsy children patients. However, this study was discontinued.

Idramantone (Kemantane) is a biologically active compound first synthesized and pharmacologically studied at the V. V. Zakusov Science Research Institute of Pharmacology, Russian Academy of Medical Sciences. Idramantone has immunostimulatory properties, which are particularly effective in the treatment of autoimmune diseases of the vascular system of the limbs, chronic bronchitis, bronchial asthma, aphthous stomatitis, herpes, and others. Idramantone also has an antiparkinsonism action. The compound has antiamnestic properties, which experimental data indicate are comparable in strength to those of memantine. Idramantone has cerebrovascular properties, increasing the blood supply in the ischemic brain. In addition, Idramantone and its derivatives are used in the electronics industry.

Ciclactate is cyclohexanol derivative patented by N. V. Koninklijke Pharmaceutische Fabrieken Voorheen Brocades-Stheeman & Pharmacia as spasmolytics and blood vessel dilator. Ciclactate has never been marketed in the US and EU.

ilofungin is a narrow spectrum antimycotic patented by a pharmaceutical company Eli Lilly and Co in 1981. Cilofungin is particularly active against the opportunistic fungal pathogen Candida albicans. Cilofungin action is exerted through inhibition of the synthesis of (1,3)-beta-glucan, an essential cell wall component, it invades a fungus' ability to synthesize cell walls.

Metacetamol (3-hydroxyacetanilide) is a structural isomer of the widely used drug paracetamol and is being considered as a promising alternative to the latter because of its lower toxicity. 3-hydroxyacetanilide, the positional isomer of paracetamol, does not cause depletion of GSH in vivo or hepatotoxicity even though the extent of covalent binding of the reactive metabolite (in vivo or in vitro) is comparable to that for an equimolar dose of paracetamol. Metacetamol should prove to be a useful tool to aid in the discrimination of hepatic acetaminophen protein adducts that may be critical or noncritical to survival of hepatocytes

ISOPREDNIDENE is a synthetic glucocorticoid. It suppresses both the release and the synthesis of adrenocorticotropin by the pituitary gland.