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Details

Stereochemistry ACHIRAL
Molecular Formula C10H14O2
Molecular Weight 166.217
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IDRAMANTONE

SMILES

OC12CC3CC(C1)C(=O)C(C3)C2

InChI

InChIKey=TZBDEVBNMSLVKT-UHFFFAOYSA-N
InChI=1S/C10H14O2/c11-9-7-1-6-2-8(9)5-10(12,3-6)4-7/h6-8,12H,1-5H2

HIDE SMILES / InChI

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/1836926 | https://www.ncbi.nlm.nih.gov/pubmed/11712183 | https://www.ncbi.nlm.nih.gov/pubmed/1860503 | https://www.ncbi.nlm.nih.gov/pubmed/11712183

Idramantone (Kemantane) is a biologically active compound first synthesized and pharmacologically studied at the V. V. Zakusov Science Research Institute of Pharmacology, Russian Academy of Medical Sciences. Idramantone has immunostimulatory properties, which are particularly effective in the treatment of autoimmune diseases of the vascular system of the limbs, chronic bronchitis, bronchial asthma, aphthous stomatitis, herpes, and others. Idramantone also has an antiparkinsonism action. The compound has antiamnestic properties, which experimental data indicate are comparable in strength to those of memantine. Idramantone has cerebrovascular properties, increasing the blood supply in the ischemic brain. In addition, Idramantone and its derivatives are used in the electronics industry.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Microbial oxidation of adamantanone by Pseudomonas putida carrying the camphor catabolic plasmid.
1992 Aug 14
Effect of adamantanone derivative possessing anti-HIV properties on the redox processes in the cytochrome P-450 system.
2001 May-Jun
Patents

Patents

Sample Use Guides

0.2g 3 times daily
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
IDRAMANTONE
INN  
INN  
Official Name English
KEMANTAN
Brand Name English
TRICYCLO(3.3.1.SUP(13,7))DECAN-2-ONE, 5-HYDROXY-
Common Name English
5-HYDROXY-2-ADAMANTANONE
Systematic Name English
idramantone [INN]
Common Name English
NSC-760375
Code English
KEMANTANE
Brand Name English
Code System Code Type Description
ChEMBL
CHEMBL2105062
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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PUBCHEM
64184
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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EVMPD
SUB08119MIG
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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SMS_ID
100000083678
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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NCI_THESAURUS
C167029
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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EPA CompTox
DTXSID8046581
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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NSC
760375
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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FDA UNII
7J4759Y5J1
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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CAS
20098-14-0
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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CHEBI
48581
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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INN
7228
Created by admin on Sat Dec 16 17:02:03 GMT 2023 , Edited by admin on Sat Dec 16 17:02:03 GMT 2023
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