U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C9H19NO2
Molecular Weight 173.2527
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IMAGABALIN

SMILES

CCC[C@@H](C)C[C@H](N)CC(O)=O

InChI

InChIKey=JXEHXYFSIOYTAH-SFYZADRCSA-N
InChI=1S/C9H19NO2/c1-3-4-7(2)5-8(10)6-9(11)12/h7-8H,3-6,10H2,1-2H3,(H,11,12)/t7-,8+/m1/s1

HIDE SMILES / InChI

Molecular Formula C9H19NO2
Molecular Weight 173.2527
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Imagabalin is a ligand to the α(2)δ subunit of voltage-sensitive calcium channel and was developed to treat generalized anxiety disorder. Imagabalin was involved in phase III clinical trials when was made a decision to terminate all studies. However, this decision was not based on any safety concerns.

Approval Year

PubMed

PubMed

TitleDatePubMed
Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: basic characterization and drug pharmacology.
2011 Jul 15
Patents

Sample Use Guides

Dosage from: 50-100 mg oral capsule Dosage and frequency: 50-350 mg once or twice a day Duration: 6 months
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Thu Jul 06 22:27:47 UTC 2023
Edited
by admin
on Thu Jul 06 22:27:47 UTC 2023
Record UNII
NDG6931B7H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IMAGABALIN
INN   USAN  
USAN   INN  
Official Name English
OCTANOIC ACID, 3-AMINO-5-METHYL-, (3S,5R)-
Common Name English
PD-0332334
Code English
PD0332334
Code English
(3S,5R)-3-Amino-5-methyl-octanoic acid
Systematic Name English
imagabalin [INN]
Common Name English
IMAGABALIN [USAN]
Common Name English
PF-00195889
Code English
Classification Tree Code System Code
NCI_THESAURUS C28197
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
Code System Code Type Description
WIKIPEDIA
Imagabalin
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
SMS_ID
300000034200
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
PUBCHEM
10236037
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
EPA CompTox
DTXSID00976534
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
USAN
UU-111
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
DRUG BANK
DB12105
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
FDA UNII
NDG6931B7H
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
CAS
610300-07-7
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
NCI_THESAURUS
C83785
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
INN
9126
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
ChEMBL
CHEMBL2103836
Created by admin on Thu Jul 06 22:27:47 UTC 2023 , Edited by admin on Thu Jul 06 22:27:47 UTC 2023
PRIMARY
Related Record Type Details
TARGET->LIGAND
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY