U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 15:02:26 GMT 2023
Edited
by admin
on Sat Dec 16 15:02:26 GMT 2023
Protein Type TRANSPORTER
Protein Sub Type ION CHANNEL
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
Z2CHJ67SHZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
Common Name English
MHS3
Common Name English
CCHL2A
Common Name English
CACNL2A
Common Name English
VOLTAGE-GATED CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1
Common Name English
Code System Code Type Description
FDA UNII
Z2CHJ67SHZ
Created by admin on Sat Dec 16 15:02:27 GMT 2023 , Edited by admin on Sat Dec 16 15:02:27 GMT 2023
PRIMARY
UNIPROT
P54289
Created by admin on Sat Dec 16 15:02:27 GMT 2023 , Edited by admin on Sat Dec 16 15:02:27 GMT 2023
PRIMARY
From To
1_380 1_1035
Glycosylation Link Type Site
N 1_68
N 1_112
N 1_160
N 1_300
N 1_324
N 1_444
N 1_451
N 1_580
N 1_589
N 1_651
N 1_757
N 1_800
N 1_864
N 1_871
N 1_961
N 1_974
Related Record Type Details
LIGAND->TARGET
LIGAND->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
PreventS [3H]gabapentin from binding in a dose-dependent manner. Lowers calcium influxupon activation.
IC50
INHIBITOR -> TARGET
ReduceS depolarization-induced calcium influx at nerve terminals, with a consequential reduction in the release of several excitatory neurotransmitters, including glutamate, noradrenaline, substance P, and CGRP.
IC50
INHIBITOR -> TARGET
LIGAND->TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL