VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 03:13:44 GMT 2025` Edited by `admin` on `Wed Apr 02 03:13:44 GMT 2025`
Protein Type	TRANSPORTER
Protein Sub Type	ION CHANNEL
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	Z2CHJ67SHZ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1

Common Name

English

CACNL2A

Preferred Name

English

MHS3

Common Name

English

CCHL2A

Common Name

English

VOLTAGE-GATED CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-1

Common Name

English

Code System Code Type Description

FDA UNII

Z2CHJ67SHZ

Created by admin on Wed Apr 02 03:13:44 GMT 2025 , Edited by admin on Wed Apr 02 03:13:44 GMT 2025

PRIMARY

UNIPROT

P54289

Created by admin on Wed Apr 02 03:13:44 GMT 2025 , Edited by admin on Wed Apr 02 03:13:44 GMT 2025

PRIMARY

From	To
1_380	1_1035

Glycosylation Link Type	Site
N	1_68
N	1_112
N	1_160
N	1_300
N	1_324
N	1_444
N	1_451
N	1_580
N	1_589
N	1_651
N	1_757
N	1_800
N	1_864
N	1_871
N	1_961
N	1_974

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AMIODARONE

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Crisugabalin

INHIBITOR -> TARGET

Comments:

PreventS [3H]gabapentin from binding in a dose-dependent manner. Lowers calcium influxupon activation.

Qualification:

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Amount:


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PREGABALIN

INHIBITOR -> TARGET

Comments:

ReduceS depolarization-induced calcium influx at nerve terminals, with a consequential reduction in the release of several excitatory neurotransmitters, including glutamate, noradrenaline, substance P, and CGRP.

Qualification:

IC50

Amount:


					1J444QC288

AMLODIPINE

INHIBITOR -> TARGET


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Gabapentin

LIGAND->TARGET

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
METAL_BINDING	[1_235] [1_237] [1_239]	SITE_SPECIFIC			CALCIUM CATION	2M83C4R6ZB
METAL_BINDING	[1_235] [1_237] [1_239]	SITE_SPECIFIC			MAGNESIUM CATION	T6V3LHY838

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL