Phosphopantothenic acid is an amidoalkyl phosphate that is the 4-phosphate derivative of (R)-pantothenic acid. Phosphopantothenic acid is not permeable to cell membranes due to its anionic character, consistent with the observation that systemic administration of Phosphopantothenic acid does not restore CoA levels in cellular and mouse models

Quindonium is azaestrone derivative patented by Shionogi & Co., Ltd. As an anti-inflammatory agent. Quindonium acts as a bradycardic agent which disrupts regular sinus rhythm in barbiturate-anesthetized dogs. Sinus bradycardias were interrupted by periods of sinus acceleration during which the disturbances in the lead II electrocardiogram were either minor or absent. The rate and rhythm changes were resistant to vagotomy or atropine, propranolol, and pentolinium. Propranolol enhanced the responses and precipitated arrhythmias in resistant animals; carotid sinus denervation had the opposite effect. Prophylactic administration of Quindonium (10 mg/kg) 15 minutes before hemorrhage produced a significant increase in the survival rate of dogs exposed to hemorrhage stress

IPROCINODINE, a semisynthetic antibiotic, is a mixture of the isopropylated cinodine I and cinodide II, glycolipid antibiotics isolated from Nocardia species.

Indium Chloride In-113 is a salt of the only stable Indium isotope with applications in organic synthesis as a Lewis acid. Indium Chloride is the most available soluble derivative of indium with high reproductive toxicity. In in vitro models, Indium Chloride inhibits cell viability by elevating intracellular ROS and inducing apoptosis. In animal models Indium chloride exposure cause the accumulation of indium in blood and lung, bone marrow micronucleus rate increased, the occurrence of oxidative damage and pathological changes. Besides that, the indium chloride exposed showed significant toxicity to sperm function, as well as an increased percentage of sperm morphological abnormality and chromatin DNA damage.

Xanthocillin is an antibiotic derived from Penicillium notatum. In vitro tests have shown that most of the common Gram-positive and Gram-negative pathogens, including Proteus and Pseudomonas pyocyanea, are sensitive to xanthocillin. Xanthocillin participated in the trial in patients with a variety of eczematous and intertriginous eruptions, in all of which bacterial infection was thought to be playing a part. Xanthocillin cream produced results, which were on par with other treatments. Information about the current use of this agent is not available.

Hydroxytamoxifen (Afimoxifene) is an active metabolite of tamoxifen exerting estrogen receptor modulatory function. In addition, hydroxytamoxifen binds to regulates transcriptional activity of the estrogen-related receptor gamma. ASCEND Therapeutics, Inc. was developing TamoGel (4-hydroxytamoxifen gel) for a variety of estrogen-dependent conditions, including breast cancer, cyclic breast pain and gynecomastia.

Nelipepimut-S (formerly known as E75) is an immunogenic peptide from the HER2 protein that is highly expressed in breast cancer. The NeuVax™ (Galena, OR, USA) vaccine, nelipepimut-S plus granulocyte-macrophage colony-stimulating factor, is designed for the prevention of clinical recurrences in high risk, disease-free breast cancer patients. Nelipepimut-S is being developed by Sellas Life Sciences Group. When combined with the immunoadjuvant granulocyte-macrophage colony-stimulating factor (GM-CSF), nelipepimut-S has been used as a vaccine that is capable of eliciting a robust anti-HER2 immune response. Early-phase clinical trials that enrolled women with node-positive or high-risk node-negative breast cancer who had been rendered disease free with standard of care therapy but were at risk for recurrence, demonstrated the vaccine to be safe with a suggestion of clinical benefit. Nelipepimut-S is currently being evaluated in a Phase III clinical trial.