Phosphopantothenic acid is an amidoalkyl phosphate that is the 4-phosphate derivative of (R)-pantothenic acid. Phosphopantothenic acid is not permeable to cell membranes due to its anionic character, consistent with the observation that systemic administration of Phosphopantothenic acid does not restore CoA levels in cellular and mouse models
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Kinetic and inhibition studies of dihydroxybenzoate-AMP ligase from Escherichia coli. | 2010-05-04 |
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| Kinetic characterization of human phosphopantothenoylcysteine synthetase. | 2009-12 |
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| Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase. | 2009-11-18 |
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| Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action. | 2009-04 |
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| Characterization and kinetics of phosphopantothenoylcysteine synthetase from Enterococcus faecalis. | 2009-03-31 |
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| Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor. | 2004-03-16 |
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EU-Orphan Drug |
EU/3/16/1612
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All of the following components must be present:
ACTIVE MOIETY
SUBSTANCE RECORD
