FOSMETPANTOTENATE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11947494 | https://www.ncbi.nlm.nih.gov/pubmed/1252995 | https://www.ncbi.nlm.nih.gov/pubmed/8582649

Phosphopantothenic acid is an amidoalkyl phosphate that is the 4-phosphate derivative of (R)-pantothenic acid. Phosphopantothenic acid is not permeable to cell membranes due to its anionic character, consistent with the observation that systemic administration of Phosphopantothenic acid does not restore CoA levels in cellular and mouse models

Approval Year

PubMed

Title	Date	PubMed
Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor.	2004 Mar 16	15005627
Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action.	2009 Apr	19307712
Kinetic characterization of human phosphopantothenoylcysteine synthetase.	2009 Dec	19683078
Characterization and kinetics of phosphopantothenoylcysteine synthetase from Enterococcus faecalis.	2009 Mar 31	19182993
Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase.	2009 Nov 18	19902973
Kinetic and inhibition studies of dihydroxybenzoate-AMP ligase from Escherichia coli.	2010 May 4	20359185

Patents

Name

Type

Language

FOSMETPANTOTENATE

Official Name

English

FOSMETPANTOTENATE [USAN]

Common Name

English

DIMETHYL 4-AMBO-(2S,8R)-8-HYDROXY-2,7,7-TRIMETHYL-4,9-DIOXO-4-PHENOXY-5-OXA-3,10-DIAZA-4.LAMBDA.5-PHOSPHATRIDECANEDIOATE

Systematic Name

English

Fosmetpantotenate [WHO-DD]

Common Name

English

RE-024

Code

English

5-OXA-3,10-DIAZA-4-PHOSPHATRIDECANEDIOIC ACID, 8-HYDROXY-2,7,7-TRIMETHYL-9-OXO-4-PHENOXY-, 1,13-DIMETHYL ESTER, 4-OXIDE, (2S,8R)-

Systematic Name

English

fosmetpantotenate [INN]

Common Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/16/1612