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Cupric benzoate is the chemical compound derived from the cupric ion and the conjugate base of benzoic acid. Cupric benzoate is used in pyrotechnics to create a blue flame. This substance is harmful if swallowed and may cause respiratory irritation. Cupric benzoate complexes incorporating 2-(4'-thiazolyl)benzimidazole (thiabendazole), 2-(2-pyridyl)benzimidazole and 1,10-phenanthroline had demonstrated anticancer activities.
tert-Butylcyanoketene reacts with tertiary amines. The reaction of tert-butylcyanoketene with a series of isocyanides results in an unusual mode of addition involving the carbonyl bond of the ketene. tert-Butylcyanoketene cycloadds to ketene, methylketene, dimethylketene, and ethylmethylketene.
Beta-Chloralose is a derivative of chloral hydrate that was used as building block in organic chemistry. Chloralose is prepared by heating equal quantities of glucose and chloral hydrate under controlled conditions so that two isomers are produced. Only alpha-chloralose has narcotic properties, beta-chloralose can produce muscular pain.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Commiphora opobalsamum is a Traditional Chinese Medicine used to treat traumatic injury, mainly by relaxing blood vessels; sandaracopimaric acid (SA) (also known as Cryptopimaric acid) was obtained from it. During investigation of SA properties was found that it was effective against phenylephrine-induced contraction of pulmonary artery rings in a concentration-dependent manner. In addition, SA showed strong inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction (100 % inhibition at 1000 mol ratio/TPA).
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
(R)-Ropivacaine (Dextroropivacaine) is a voltage-dependent potassium channel blocker with local anesthetic activity. (S)-Ropivacaine is a medication used for the production of local or regional anesthesia for surgery and for acute pain management. Ropivacaine shows a difference in channel blockade between two enantiomers, and R-Ropivacaine shows greater cardiotoxicity than (S)-Ropivacaine. (R)-Ropivacaine is the impurity in commercial formulations of Ropivacaine.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Minoxidil, a trichogenic compound that stimulates the hair follicle, is a pro-drug converted to its active form, minoxidil sulfate, by sulfotransferase enzymes in the outer root sheath of hair. Minoxidil sulfate is required for both the promotion of hair regrowth and the vasodilatory effects of minoxidil. Minoxidil sulfate is an activator of the ATP-sensitive K+ (KATP) channel. The opening of K+ channels is thought to be an important mechanism in the regulation of hair follicles.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Nutlin-3b is pharmacologically inactive enantiomer of an Mdm2 (mouse double minute 2) antagonist and apoptosis inducer nutlin-3. Nutlin-3b binds to MDM2 with 200-fold lower affinity and is 150 times less active in vitro than 3a (an active enantiomer of nutlin-3). Nutlin-3b does not show any effect on the cell cycle and proliferation and has no insignificant effect on gene expression in cancer cells. Nutlin-3b is usually used as a negative control.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Isopilocarpine is a diastereomer of pilocarpine. Isopilocarpine coexists with pilocarpine in nature and is also a degradation product of pilocarpine after oral administration to humans. It can be found in the leaves of some Pilocarpus species. Pilocarpine targets the muscarinic receptors and is approved for treatment of xerostomia. Isopilocarpine is often present in formulations of pilocarpine but has no appreciable effect on muscarinic receptors.
(+)-Gallocatechin gallate is a polyphenol, which occurs naturally in green tea leaves.
Status:
Other
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Allopregnan-3α-ol-20-one acetate (5α-Pregnan-3β-ol-20-one 3β-acetate) is a derivative of neurosteroid Allopregnanolone. Allopregnan-3α-ol-20-one acetate is an allosteric modulator of inhibitory γ-aminobutyric acid (GABA-A) receptors on neural stem cells and other cell types in the brain. Allopregnanolone acetate exerted moderate antidystonic effects and provoked a moderately reduced locomotor activity in animal models. Metabolic transformation of Allopregnan-3α-ol-20-one acetate leads Allopregnanolone. Allopregnanolone is in phase III trials for the treatment of super-refractory status epilepticus (SRSE) and postpartum depression, but Allopregnan-3α-ol-20-one acetate was never tested in clinical trials.