Details
Stereochemistry | ACHIRAL |
Molecular Formula | C9H15N5O4S |
Molecular Weight | 289.312 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC(=CC(=N)N1OS(O)(=O)=O)N2CCCCC2
InChI
InChIKey=KVOZMWUBYWDGEX-UHFFFAOYSA-N
InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
Molecular Formula | C9H15N5O4S |
Molecular Weight | 289.312 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Minoxidil, a trichogenic compound that stimulates the hair follicle, is a pro-drug converted to its active form, minoxidil sulfate, by sulfotransferase enzymes in the outer root sheath of hair. Minoxidil sulfate is required for both the promotion of hair regrowth and the vasodilatory effects of minoxidil. Minoxidil sulfate is an activator of the ATP-sensitive K+ (KATP) channel. The opening of K+ channels is thought to be an important mechanism in the regulation of hair follicles.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: ATP-sensitive potassium channel Sources: https://www.ncbi.nlm.nih.gov/pubmed/9395721 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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PubMed
Title | Date | PubMed |
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Biochemical mechanisms by which minoxidil sulfate influences mammalian cells. | 1987 |
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Minoxidil sulfate is the active metabolite that stimulates hair follicles. | 1990 Nov |
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Vascular pharmacology of ATP-sensitive K+ channels: interactions between glyburide and K+ channel openers. | 1993 Jan-Feb |
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Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway. | 2013 Dec |
Patents
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3385640
The mechanism of smooth muscle relaxing effect of minoxidil sulfate (MxSO4) was investigated in isolated rabbit superior mesenteric artery. MxSO4 (5 X 10(-6) M) was found to effectively relax maximal norepinephrine (NE; at 5 X 10(-6) M) contraction, but failed to relax 80 mM K+-induced contraction. MxSO4-induced relaxation was endothelium independent. Tetraethylammonium (5-10 mM) pretreatment caused pronounced inhibition of MxSO4-induced relaxation. Pretreatment with ouabain (0.5-5 microM) also significantly inhibited MxSO4 relaxation.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:26:45 UTC 2023
by
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on
Sat Dec 16 08:26:45 UTC 2023
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Record UNII |
2H6K6Y231J
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Record Status |
Validated (UNII)
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Record Version |
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