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Details

Stereochemistry ACHIRAL
Molecular Formula C9H15N5O4S
Molecular Weight 289.312
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MINOXIDIL SULFATE ESTER

SMILES

NC1=NC(=CC(=N)N1OS(O)(=O)=O)N2CCCCC2

InChI

InChIKey=KVOZMWUBYWDGEX-UHFFFAOYSA-N
InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)

HIDE SMILES / InChI

Molecular Formula C9H15N5O4S
Molecular Weight 289.312
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Minoxidil, a trichogenic compound that stimulates the hair follicle, is a pro-drug converted to its active form, minoxidil sulfate, by sulfotransferase enzymes in the outer root sheath of hair. Minoxidil sulfate is required for both the promotion of hair regrowth and the vasodilatory effects of minoxidil. Minoxidil sulfate is an activator of the ATP-sensitive K+ (KATP) channel. The opening of K+ channels is thought to be an important mechanism in the regulation of hair follicles.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: ATP-sensitive potassium channel
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Biochemical mechanisms by which minoxidil sulfate influences mammalian cells.
1987
Minoxidil sulfate is the active metabolite that stimulates hair follicles.
1990 Nov
Vascular pharmacology of ATP-sensitive K+ channels: interactions between glyburide and K+ channel openers.
1993 Jan-Feb
Minoxidil sulfate induced the increase in blood-brain tumor barrier permeability through ROS/RhoA/PI3K/PKB signaling pathway.
2013 Dec
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
The mechanism of smooth muscle relaxing effect of minoxidil sulfate (MxSO4) was investigated in isolated rabbit superior mesenteric artery. MxSO4 (5 X 10(-6) M) was found to effectively relax maximal norepinephrine (NE; at 5 X 10(-6) M) contraction, but failed to relax 80 mM K+-induced contraction. MxSO4-induced relaxation was endothelium independent. Tetraethylammonium (5-10 mM) pretreatment caused pronounced inhibition of MxSO4-induced relaxation. Pretreatment with ouabain (0.5-5 microM) also significantly inhibited MxSO4 relaxation.
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:26:45 UTC 2023
Edited
by admin
on Sat Dec 16 08:26:45 UTC 2023
Record UNII
2H6K6Y231J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MINOXIDIL SULFATE ESTER
Common Name English
2-PYRIMIDINAMINE, 1,6-DIHYDRO-6-IMINO-4-(1-PIPERIDINYL)-1-(SULFOOXY)-
Systematic Name English
Code System Code Type Description
CAS
83701-22-8
Created by admin on Sat Dec 16 08:26:45 UTC 2023 , Edited by admin on Sat Dec 16 08:26:45 UTC 2023
PRIMARY
RXCUI
1926479
Created by admin on Sat Dec 16 08:26:45 UTC 2023 , Edited by admin on Sat Dec 16 08:26:45 UTC 2023
PRIMARY
PUBCHEM
138113345
Created by admin on Sat Dec 16 08:26:45 UTC 2023 , Edited by admin on Sat Dec 16 08:26:45 UTC 2023
PRIMARY
FDA UNII
2H6K6Y231J
Created by admin on Sat Dec 16 08:26:45 UTC 2023 , Edited by admin on Sat Dec 16 08:26:45 UTC 2023
PRIMARY
DAILYMED
2H6K6Y231J
Created by admin on Sat Dec 16 08:26:45 UTC 2023 , Edited by admin on Sat Dec 16 08:26:45 UTC 2023
PRIMARY
EPA CompTox
DTXSID201162085
Created by admin on Sat Dec 16 08:26:45 UTC 2023 , Edited by admin on Sat Dec 16 08:26:45 UTC 2023
PRIMARY
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