Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.451 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@@]1(CC[C@H]2C(CC[C@@H]3[C@]2(C)CCC[C@@]3(C)C(O)=O)=C1)C=C
InChI
InChIKey=MHVJRKBZMUDEEV-KRFUXDQASA-N
InChI=1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,13,15-16H,1,6-12H2,2-4H3,(H,21,22)/t15-,16+,18-,19+,20+/m0/s1
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.451 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Commiphora opobalsamum is a Traditional Chinese Medicine used to treat traumatic injury, mainly by relaxing blood vessels; sandaracopimaric acid (SA) (also known as Cryptopimaric acid) was obtained from it. During investigation of SA properties was found that it was effective against phenylephrine-induced contraction of pulmonary artery rings in a concentration-dependent manner. In addition, SA showed strong inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction (100 % inhibition at 1000 mol ratio/TPA).
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2111413 |
364.8 µM [EC50] | ||
Target ID: CHEMBL2111392 |
289.5 µM [EC50] | ||
Target ID: GABA(A) receptor α₅β₂γ(2S) |
317.0 µM [EC50] | ||
Target ID: Epstein-Barr virus early antigen (EBV-EA) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Preparative mass-spectrometry profiling of bioactive metabolites in Saudi-Arabian propolis fractionated by high-speed countercurrent chromatography and off-line atmospheric pressure chemical ionization mass-spectrometry injection. | 2014-06-20 |
|
| [Study on chemical constituents from petroleum ether-soluble parts of cones of Platycladus orientalis]. | 2012-10 |
|
| Antimycobacterial plant terpenoids. | 2001-11 |
|
| Diterpenes from the berries of Juniperus excelsa. | 1999-04 |
|
| On cryptopimaric acid and neoisopimaric acid. | 1962-10 |
Sample Use Guides
Pulmonary artery rings were pretreated with phenylephrine (PE) (10−6 M), and then andaracopimaric acid (Cryptopimaric acid) (5, 10, 20, 40, 80 μM) was accumulatively added to the bath. It was found that SA was effective against PE-induced contraction of pulmonary artery rings in a concentration-dependent manner.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:05:36 GMT 2025
by
admin
on
Mon Mar 31 22:05:36 GMT 2025
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| Record UNII |
P4BJH0IA3Z
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Validated (UNII)
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